Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4 nanoparticles

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dc.creatorPróspero, André Gonçalves
dc.creatorBuranello, Lais Pereira
dc.creatorFernandes, Carlos Alexandre Henrique
dc.creatorSantos, Lucilene Delazari dos
dc.creatorSoares, Guilherme Augusto
dc.creatorRossini, Bruno César
dc.creatorZufelato, Nícholas
dc.creatorBakuzis, Andris Figueiroa
dc.creatorFontes, Marcos Roberto de Mattos
dc.creatorMiranda, Jose Ricardo de Arruda
dc.date.accessioned2023-11-16T13:00:58Z
dc.date.available2023-11-16T13:00:58Z
dc.date.issued2021
dc.description.abstractBackground: We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. Methods: We employed the ACB system, gel electrophoresis and mass spectrometry analysis. Results: Higher CP formation led to a greater reduction in the in vitro ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time in vivo among the MNPs studied. Conclusion: These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs.
dc.identifier.citationPRÓSPERO, Andre Gonçalves et al. Corona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe 2 O 4 nanoparticles. Nanomedicine, London, v. 16, n. 24, p. 2189-2206, 2021. DOI: 10.2217/nnm-2021-0195. Disponúvel em: https://www.futuremedicine.com/doi/10.2217/nnm-2021-0195?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed. Acesso em: 12 set. 2023.
dc.identifier.doi10.2217/nnm-2021-0195
dc.identifier.issn1743-5889
dc.identifier.issne- 1748-6963
dc.identifier.urihttps://www.futuremedicine.com/doi/10.2217/nnm-2021-0195?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.rightsAcesso Restrito
dc.titleCorona protein impacts on alternating current biosusceptometry signal and circulation times of differently coated MnFe2O4 nanoparticles
dc.typeArtigo

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