3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp
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2023-01-20
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Aims: Considering the need to identify new compounds with antifungal action, the activity of five 3-phenacylideneoxindoles compounds was evaluated. Materials & methods: The compounds were synthesized, and their antifungal activity was elucidated through minimum inhibitory concentration tests and interaction assay with other antifungals. Potential targets of compounds were predicted in silico. Results: 3-phenacylideneoxindoles compounds inhibited fungal growth with minimum inhibitory concentration and minimum fungicidal concentration ranging from 3.05 to 12.26 μM. The compounds demonstrated high selectivity index and presented a synergistic effect with itraconazole. In silico prediction revealed the pentafunctional AROM polypeptide, enolase, superoxide dismutase, catalase and kinases as proteins targets of the compound 4a. Conclusion: The results demonstrate that 3-phenacylideneoxindoles is a potential new class of antifungal compounds for paracoccidioidomycosis treatment.
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3-phenacylideneoxindoles, Antifungal, Paracoccidioidomycosis, Target proteins
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SILVA, Lívia C. et al. 3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp. Future Microbiology, London, v. 18, n. 2, p. 93-105, 2023. DOI: 10.2217/fmb-2022-0133. Disponível em: https://www.futuremedicine.com/doi/10.2217/fmb-2022-0133. Acesso em: 6 nov. 2023.