3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp

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dc.creatorSilva, Lívia do Carmo
dc.creatorSantos Filho, Raimundo Francisco dos
dc.creatorOliveira, Amanda Alves de
dc.creatorMartins, Felipe Terra
dc.creatorCunha, Silvio do Desterro
dc.creatorSoares, Célia Maria de Almeida
dc.creatorPereira, Maristela
dc.date.accessioned2023-11-10T12:24:56Z
dc.date.available2023-11-10T12:24:56Z
dc.date.issued2023-01-20
dc.description.abstractAims: Considering the need to identify new compounds with antifungal action, the activity of five 3-phenacylideneoxindoles compounds was evaluated. Materials & methods: The compounds were synthesized, and their antifungal activity was elucidated through minimum inhibitory concentration tests and interaction assay with other antifungals. Potential targets of compounds were predicted in silico. Results: 3-phenacylideneoxindoles compounds inhibited fungal growth with minimum inhibitory concentration and minimum fungicidal concentration ranging from 3.05 to 12.26 μM. The compounds demonstrated high selectivity index and presented a synergistic effect with itraconazole. In silico prediction revealed the pentafunctional AROM polypeptide, enolase, superoxide dismutase, catalase and kinases as proteins targets of the compound 4a. Conclusion: The results demonstrate that 3-phenacylideneoxindoles is a potential new class of antifungal compounds for paracoccidioidomycosis treatment.
dc.identifier.citationSILVA, Lívia C. et al. 3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp. Future Microbiology, London, v. 18, n. 2, p. 93-105, 2023. DOI: 10.2217/fmb-2022-0133. Disponível em: https://www.futuremedicine.com/doi/10.2217/fmb-2022-0133. Acesso em: 6 nov. 2023.
dc.identifier.doi10.2217/fmb-2022-0133
dc.identifier.issn1746-0913
dc.identifier.issne- 1746-0921
dc.identifier.urihttps://www.futuremedicine.com/doi/10.2217/fmb-2022-0133
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Restrito
dc.subject3-phenacylideneoxindoles
dc.subjectAntifungal
dc.subjectParacoccidioidomycosis
dc.subjectTarget proteins
dc.title3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp
dc.typeArtigo

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