3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp
dc.creator | Silva, Lívia do Carmo | |
dc.creator | Santos Filho, Raimundo Francisco dos | |
dc.creator | Oliveira, Amanda Alves de | |
dc.creator | Martins, Felipe Terra | |
dc.creator | Cunha, Silvio do Desterro | |
dc.creator | Soares, Célia Maria de Almeida | |
dc.creator | Pereira, Maristela | |
dc.date.accessioned | 2023-11-10T12:24:56Z | |
dc.date.available | 2023-11-10T12:24:56Z | |
dc.date.issued | 2023-01-20 | |
dc.description.abstract | Aims: Considering the need to identify new compounds with antifungal action, the activity of five 3-phenacylideneoxindoles compounds was evaluated. Materials & methods: The compounds were synthesized, and their antifungal activity was elucidated through minimum inhibitory concentration tests and interaction assay with other antifungals. Potential targets of compounds were predicted in silico. Results: 3-phenacylideneoxindoles compounds inhibited fungal growth with minimum inhibitory concentration and minimum fungicidal concentration ranging from 3.05 to 12.26 μM. The compounds demonstrated high selectivity index and presented a synergistic effect with itraconazole. In silico prediction revealed the pentafunctional AROM polypeptide, enolase, superoxide dismutase, catalase and kinases as proteins targets of the compound 4a. Conclusion: The results demonstrate that 3-phenacylideneoxindoles is a potential new class of antifungal compounds for paracoccidioidomycosis treatment. | |
dc.identifier.citation | SILVA, Lívia C. et al. 3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp. Future Microbiology, London, v. 18, n. 2, p. 93-105, 2023. DOI: 10.2217/fmb-2022-0133. Disponível em: https://www.futuremedicine.com/doi/10.2217/fmb-2022-0133. Acesso em: 6 nov. 2023. | |
dc.identifier.doi | 10.2217/fmb-2022-0133 | |
dc.identifier.issn | 1746-0913 | |
dc.identifier.issn | e- 1746-0921 | |
dc.identifier.uri | https://www.futuremedicine.com/doi/10.2217/fmb-2022-0133 | |
dc.language.iso | eng | |
dc.publisher.country | Gra-bretanha | |
dc.publisher.department | Instituto de Química - IQ (RMG) | |
dc.rights | Acesso Restrito | |
dc.subject | 3-phenacylideneoxindoles | |
dc.subject | Antifungal | |
dc.subject | Paracoccidioidomycosis | |
dc.subject | Target proteins | |
dc.title | 3-phenacylideneoxindoles as a new class of antifungal compounds against Paracoccidioides spp | |
dc.type | Artigo |
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