Antidepressive-like property of dichloromethane fraction of pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymes
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2013
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Pimenta pseudocaryophyllus popularly referred to as craveiro is considered as a calming agent in different local preparations. e
present study attempted to examine antidepressant-like effect of dichloromethane fraction (DF) and role of monoamine oxidase
(MAO), tryptophan, and tyrosine hydroxylase. Based on the research focus, tail suspension (TS), forced swimming (FS), and
open �eld (OF) tests were conducted a�er oral administration of DF (125, 250, or 500 mg/Kg). Ex vivo assay of MAO was also
conducted to evaluate inhibitory effect of DF (250 mg/Kg). Administration of DF elicits antidepressant-like response in the TS and
FS. However, DF 500 mg/Kg did not alter mice performance in these models. e data obtained in the OF showed a reduction
in total crossing and rearing activity; these effects suggest motor interference in TS and FS performance. Mice pretreatment with
p-chlorophenylalanine methyl ester (PCPA) (100 mg/kg, i.p.—serotonin biosynthesis inhibitor) for 4 consecutive days or acute
administration of αα-methyl-p-tyrosine (AMPT) (100 mg/kg, i.p.—catecholamine synthesis inhibitor) blocked anti-immobility
effect of DF in the FS. In ex vivo assay of MAO, DF did not inhibit catabolic activity of MAO. Our �ndings support antidepressant-
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FAJEMIROYE, James Oluwagbamigbe et al. Antidepressive-like property of dichloromethane fraction of pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymes. Evidence-Based Complementary and Alternative Medicine, London, v. 2013, p. 1-8, 2013.