Antidepressive-like property of dichloromethane fraction of pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymes

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dc.creatorFajemiroye, James Oluwagbamigbe
dc.creatorMartins, José Luís Rodrigues
dc.creatorGhedini, Paulo César
dc.creatorCarvalho, Pablinny Moreira Galdino de
dc.creatorPaula, Joelma Abadia Marciano de
dc.creatorPaula, José Realino de
dc.creatorRocha, Fabio Fagundes da
dc.creatorCosta, Elson Alves
dc.date.accessioned2018-09-05T11:32:59Z
dc.date.available2018-09-05T11:32:59Z
dc.date.issued2013
dc.description.abstractPimenta pseudocaryophyllus popularly referred to as craveiro is considered as a calming agent in different local preparations. e present study attempted to examine antidepressant-like effect of dichloromethane fraction (DF) and role of monoamine oxidase (MAO), tryptophan, and tyrosine hydroxylase. Based on the research focus, tail suspension (TS), forced swimming (FS), and open �eld (OF) tests were conducted a�er oral administration of DF (125, 250, or 500 mg/Kg). Ex vivo assay of MAO was also conducted to evaluate inhibitory effect of DF (250 mg/Kg). Administration of DF elicits antidepressant-like response in the TS and FS. However, DF 500 mg/Kg did not alter mice performance in these models. e data obtained in the OF showed a reduction in total crossing and rearing activity; these effects suggest motor interference in TS and FS performance. Mice pretreatment with p-chlorophenylalanine methyl ester (PCPA) (100 mg/kg, i.p.—serotonin biosynthesis inhibitor) for 4 consecutive days or acute administration of αα-methyl-p-tyrosine (AMPT) (100 mg/kg, i.p.—catecholamine synthesis inhibitor) blocked anti-immobility effect of DF in the FS. In ex vivo assay of MAO, DF did not inhibit catabolic activity of MAO. Our �ndings support antidepressant-pt_BR
dc.identifier.citationFAJEMIROYE, James Oluwagbamigbe et al. Antidepressive-like property of dichloromethane fraction of pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymes. Evidence-Based Complementary and Alternative Medicine, London, v. 2013, p. 1-8, 2013.pt_BR
dc.identifier.doi10.1155/2013/659391
dc.identifier.issn1741-427X
dc.identifier.issne- 1741-4288
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15832
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAntidepressive-like property of dichloromethane fraction of pimenta pseudocaryophyllus and relevance of monoamine metabolic enzymespt_BR
dc.typeArtigopt_BR

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