Mechanism involved in the anti-infl ammatory effect of Spiranthera odoratissima (Manacá)
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Data
2012-02
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Resumo
Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy,
formalin-induced pain, croton oil-induced ear edema, vascular permeability tests
and phospholipase A 2 activity assay were used to study the analgesic and/or anti-
inflammatory activity of the hydromethanolic fraction of ethanolic extract from
Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction
(sub-Fr 10-28 ). HMF and sub-Fr 10-28 reduced the leukocyte migration on the carrageenan-
induced pleurisy test; sub-Fr 10-28 reduced the pain reaction time in the second phase
of formalin-induced pain, as well as the ear edema and vascular permeability. Both
HMF and sub-Fr 10-28 inhibited the phospholipase A 2 activity. These results suggest
that the analgesic effect of this plant could be, in part, due to an anti-inflammatory
action produced by the inhibition of phospholipase A 2 activity.
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Anti-inflammatory, Antinociceptive, Medicinal plant, Phospholipase A 2, Spiranthera odoratissima
Citação
BARBOSA, Daniela B. M. e al. Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá). Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, p. 137-143, Jan./Feb. 2012.