Mechanism involved in the anti-infl ammatory effect of Spiranthera odoratissima (Manacá)

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dc.creatorBarbosa, Daniela Borges Marquez
dc.creatorNascimento, Marcus Vinicius Martins do
dc.creatorLino, Roberta Campos
dc.creatorMagalhães, Marta Regina
dc.creatorFlorentino, Iziara Ferreira
dc.creatorHonório, Tereza Cristina de Deus
dc.creatorCarvalho, Pablinny Moreira Galdino de
dc.creatorBara, Maria Teresa Freitas
dc.creatorPaula, José Realino de
dc.creatorCosta, Elson Alves
dc.date.accessioned2018-09-06T11:08:31Z
dc.date.available2018-09-06T11:08:31Z
dc.date.issued2012-02
dc.description.abstractAcetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A 2 activity assay were used to study the analgesic and/or anti- inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr 10-28 ). HMF and sub-Fr 10-28 reduced the leukocyte migration on the carrageenan- induced pleurisy test; sub-Fr 10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr 10-28 inhibited the phospholipase A 2 activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A 2 activity.pt_BR
dc.identifier.citationBARBOSA, Daniela B. M. e al. Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá). Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, p. 137-143, Jan./Feb. 2012.pt_BR
dc.identifier.doi10.1590/S0102-695X2011005000154 
dc.identifier.issn0102-695X
dc.identifier.issne- 1981-528X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15864
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAnti-inflammatorypt_BR
dc.subjectAntinociceptivept_BR
dc.subjectMedicinal plantpt_BR
dc.subjectPhospholipase A 2pt_BR
dc.subjectSpiranthera odoratissimapt_BR
dc.titleMechanism involved in the anti-infl ammatory effect of Spiranthera odoratissima (Manacá)pt_BR
dc.typeArtigopt_BR

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