Brazilian hepatitis B vaccine: a six-year follow-up in adolescents
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2012-12
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The protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (> 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlation was observed between the anti-HBs titres after the primary vaccination and the titres at the six-year follow-up (p < 0.01). Eleven subjects showed anti-HBs titres suggestive of a natural booster. Prostitution and tattoos/piercings were marginally associated with natural boosters in the multivariate analysis. This study showed the first data on anti-HBs persistence following the Brazilian hepatitis B vaccine in sexually active individuals and highlights its effectiveness in the medium term.
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Hepatitis B vaccine, Adolescents, Follow-up
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ALEXANDRE, Kamilla Vêncio Frauzino; MARTINS, Regina Maria Bringel; SOUZA, Márcia Maria de; RODRIGUES, Isolina Maria Xavier; TELES, Sheila Araújo. Brazilian hepatitis B vaccine: a six-year follow-up in adolescents. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 8, p. 1060-1063, Dec. 2012.