Absence of antimutagenicity of Cochlospermum regium ( Mart and Schr.) Pilger 1924 by micronucleus test in mice
Data
2008
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Resumo
Cochlospermum regium (Mart. and Schr.) Pilger, popularly known as “algodãozinho do campo”, is a medicinal plant
that grows in the Cerrado of Brazil. This plant has been used in traditional medicine against various diseases such as
leucorrhoea, gastritis and ulcers. It has also been effective in treating skin problems like pimples, boils and blotches. In
the present study, the in vivo antimutagenicity of aqueous extract of C. regium was evaluated. The Micronucleus Test
was performed in polychromatic erythrocytes from Swiss male mice treated with one of the four doses of extract of the
plant (19, 38, 76 and 114 mg.kg –1 body weight), administered by intraperitonial injection (i.p.) simultaneously with cy-
clophosphamide (24 mg.kg –1 b.w.) or mitomycin C (4 mg.kg –1 b.w.). The cytotoxicity was evaluated by polychromatic
and normochromatic erythrocytes ratio (PCE/NCE). The results showed no significant reduction of the micronucleated
polychromatic erythrocytes frequency (P > 0.05). In conclusion, the data indicate that C. regium roots aqueous extract,
for the conditions used, did not exhibit the antimutagenic effect.
Descrição
Palavras-chave
Cochlospermum regium, Mice, Antimutagenicity, Micronucleus
Citação
ANDRADE, L. S. et al. Absence of antimutagenicity of Cochlospermum regium ( Mart and Schr.) Pilger 1924 by micronucleus test in mice. Brazilian Journal of Biology, São Carlos, v. 68, n. 1, p. 163-167, Feb. 2008.