Programa de Pós-graduação em Biodiversidade Vegetal
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Navegando Programa de Pós-graduação em Biodiversidade Vegetal por Por Orientador "Santos, Suzana da Costa"
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Item Avaliação da atividade genotóxica e antigenotóxica do elagitanino oenoteina B isolado de Eugenia uniflora L.(Universidade Federal de Goiás, 2014-02-18) Silva, Cínthia Aparecida da; Lee, Chen Chen; Santos, Suzana da Costa; http://lattes.cnpq.br/7811945085200334The species Eugenia uniflora L. belongs to the Myrtaceae family and is known as “pitangueira”. It is characterized by small fruit trees that have great therapeutic potential. The leaves of E. uniflora are rich in hydrolyzable tannins, and the ellagitannin oenothein B has been studied for its remarkable antitumor activity, representing a possibility for the treatment of some cancers. However, there is a need for evaluation of possible mutagenic, genotoxic and toxic effects, which may result in damage to the human body. Three doses of oenoteina B (25, 50 and 75 mg/kg) were used in the micronucleus test, and the same doses along with mitomycin C. Five doses of oenoteina B were used in SOS inductest (10, 20, 50, 100 and 200 μg/plate) to evaluate the possible genotoxic or antigenotoxic action and examining the cytotoxic or anticytotoxic activity of this tannin. Our data showed that oenoteina B did not exhibit genotoxic effects, and furthermore, this ellagitannin demonstrated protective action against micronucleus formation induced by mitomycin C in mice. The possible use of oenoteina B as a chemopreventive and/or therapeutic agent still needs further studies using different tests for genotoxicity, applied to longterm, pre- and post-treatments, to investigate the mechanism of action of this compound.