Programa de Pós-graduação em Biologia da Relação Parasito-Hospedeiro
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Navegando Programa de Pós-graduação em Biologia da Relação Parasito-Hospedeiro por Por Orientador "Fonseca, Simone Gonçalves da"
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Item Avaliação da resposta imune após vacinação para covid-19(Universidade Federal de Goiás, 2023-08-28) Masson, Letícia Carrijo; Fonseca, Simone Gonçalves da; http://lattes.cnpq.br/3823367099967701; http://lattes.cnpq.br/3823367099967701; Fonseca, Simone Gonçalves da; Kipnis, Ana Paula Junqueira; Oliveira, Milton Adriano Pelli deImmune responses after COVID-19 vaccination should be evaluated in different populations around the world. This study compared antibody responses induced by ChAdOx1 nCoV-19, CoronaVac, and BNT162b2 vaccines. Blood samples from vaccinees were collected pre- and post-vaccinations with the second and third doses. The study enrolled 78 vaccinees, of whom 62.8% were women, with the following median ages: 26 years—ChAdOx1 nCoV-19; 40 years—CoronaVac; 30 years—BNT162b2. Serum samples were quantified for anti-Receptor Binding Domain (RBD) IgG and anti-RBD IgA and anti-spike IgG by ELISA. After two vaccine doses, BNT162b2 vaccinees produced higher levels of anti-RBD IgA and IgG, and anti-spike IgG compared to ChAdOx1 nCoV-19 and CoronaVac vaccinees. The third dose booster with BNT162b2 induced higher levels of anti-RBD IgA and IgG, and anti-spike IgG in CoronaVac vaccinees. Individuals who reported a SARS-CoV-2 infection before or during the study had higher anti-RBD IgA and IgG production. In conclusion, two doses of the studied vaccines induced detectable levels of anti-RBD IgA and IgG and anti-spike IgG in vaccinees. The heterologous booster with BNT162b2 increased anti-RBD IgA and IgG and anti-spike IgG levels in CoronaVac vaccinees and anti-RBD IgA levels in ChAdOx1 nCoV-19 vaccinees. Furthermore, SARS-CoV-2 infection induced higher anti-RBD IgA and IgG levels in CoronaVac vaccinees. NovembroItem Efeitos do uso de drogas ilícitas na resposta inflamatória(Universidade Federal de Goiás, 2015-11-27) Ribeiro, Camila Bastos; Fonseca, Simone Gonçalves da; http://lattes.cnpq.br/3823367099967701; Fonseca, Simone Gonçalves da; Oliveira, Milton Adriano Pelli de; Cunha, Luiz Carlos daStudies have reported that illicit drugs can alter immune system function and further suggest a greater commitment related to the use of these drugs, such as increased susceptibility to infection and progression to disease. Considering these effects in the body, we conducted a study to investigate the effect of drug use on the inflammatory response in subjects grouped according to the drug used: marijuana, cocaine and crack users and individuals from more than one drug. Thus, the study groups were: 1. non drug users (control); 2. marijuana users; 3. Cocaine/crack users; 4.cocaine/crack/marijuana users (multiuser). The profile of proinflammatory and anti-inflammatory cytokines and C-reactive protein (CRP) in the plasma of study subjects was investigated. There were also measured the levels of soluble CD14 (sCD14) and lipopolysaccharide (LPS) circulating in the plasma of individuals that are indicative of microbial translocation. We obtained high levels of sCD14, LPS, CRP, IL-6 and IL-8 in multi-user group and decreased levels of IL-6 and TNF- in cannabis user group compared to the control group. This set of findings suggests that illicit drugs may be causing a change in the integrity of the intestinal mucosa multiuser individuals due to the increased presence of LPS and sCD14 was detected in the circulation and changes in the inflammatory response with increased production and / or decreased biomarkers relevant inflammation.Item Avaliação da produção de citocinas, quimiocinas e fatores de crescimento nas fases aguda e convalescente da infecção pelo vírus Zika em área endêmica(Universidade Federal de Goiás, 2017-12-05) Silva, Paulo Alex Neves da; Fonseca, Simone Gonçalves da; http://lattes.cnpq.br/3823367099967701; Fonseca, Simone Gonçalves da; Souza, Menira Borges de Lima Dias e; Oliveira, Milton Adriano Pelli deThe Zika virus (ZIKV) is transmitted by the bite of the mosquito, mainly of the genus Aedes. The virus was first isolated in nonhuman primates in Zika forest in Uganda in 1947. Between 1953-2006, there were sporadic cases of ZIKV infection in humans in Africa, Asia and Oceania, and it was considered benign. In 2007, there was the first outbreak of the ZIKV and from that time, began to emerge complications such as microcephaly and Guillain-Barre syndrome. Approximately 80% of ZIKV infection cases are asymptomatic, but when symptoms do occur are usually mild and nonspecific. The objective of this study was to evaluate plasma levels of cytokines, chemokines and growth factors for infection ZIKV in acute and convalescente phases. Few immune mediators had significantly higher levels in the acute phase, namely IFN-γ, IP-10 and RANTES when compared to healthy donors. In addition, plasma levels of IP-10 were also significantly higher in the acute phase of infection when compared to the convalescent phase. No associations were observed between cytokine, chemokines and growth factor levels that were evaluated, and the number of symptoms or viremia. Together, our data indicate that the Zika virus infection during acute phase, in endemic areas, is able to stimulate the immune system in a subtle way and with a markedly pro-inflammatory profile, and it may not be able to eliminate the viral infection efficiently, collaborating for the immunopathogenesis of the infection and favoring viral dissemination.