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Item Efeito da solução de Carolina Rinse na injúria de isquemia e reperfusão experimental no intestino delgado de coelhos(Universidade Federal de Goiás, 2011-11-18) BRANDSTETTER, Luciana Ramos Gaston; MOURA, Veridiana Maria Brianezi Dignani de; http://lattes.cnpq.br/8773201078957745; FIORAVANTI, Maria Clorinda Soares; http://lattes.cnpq.br/8772502020076257; ARAÚJO, Eugênio Gonçalves de; http://lattes.cnpq.br/3919777570059928Mechanic obstruction of blood vessels that irrigate the intestine leads to ischemia and intense reduction of oxygenation and tissue perfusion. If oxygenated blood flow returns abruptly to tissues before cellular death reperfusion injury occurs; this can be initiated by several mechanisms resulting in inflammatory response. Intestinal ischemia/reperfusion (I/R) injury has been widely associated to cell necrosis, although another distinct biochemical and morphological type of cell death, called apoptosis, is involved. Such conditions are mediated by signaling molecules in cellular surface, which lead to long term changes in gene expression. In the majority of cells, MAP (Mitogen Activated Protein) kinases (MAPK), which are part of a group of cytoplasmic enzymes, will transmit mitogenic and cell differentiation signs. Three MAPK that have been identified in mammalian cells participate in the signaling pathway: ERK, p38 and JNK. Activated p38 and JNK are usually related to apoptosis, while activated ERK 1/2 (P44/42) have a protection function inhibiting apoptosis. With the purpose of minimizing reperfusion injury after liver transplant, Carolina Rinse Solution (CRS) was designed by North Carolina University, USA. Although this solution has been used in horses to attenuate I/R injury in horse intestine, little is known about the eventual tissue protection mechanism. The present study aimed to investigate the effects of topical and intraluminal CRS in I/R injury, and the activation profile of p38 and ERK 1/2 MAPK, in rabbit jejunum. Fifteen New Zealand rabbits were allocated to three groups: Sham-operated (A), Ischemia and reperfusion (B) and CRS (C). Groups B and C were subjected to one hour of jejunal ischemia and two hours of reperfusion. In group C, ten minutes prior to reperfusion, the bowel lumen was filled with CRS, and the segment was immersed in CRS until reperfusion onset. Changes such as degeneration, necrosis, edema, hemorrhage, PMN infiltration and margination were not significantly different between groups B and C, showing that topical and intraluminal CRS did not attenuate deleterious effects of I/R in small intestinal of rabbits. I/R stimulated the phosphorylation of p44/42 MAPK and p38 MAPK pathways in some layers of jejunum. Progressive activation of p44/42 MAPK was chiefly localized to the crypts of Lieberkühn, circular and longitudinal muscle layers, whereas p38 MAPK was prominently activated in myenteric plexus and both muscle layers. All layers that did respond to I/R insult with activation increase of ERK 1/2 and p38, in all groups, showed low baseline phosphorylation levels as compared to those that did not react to the insult. The results of this work indicate that topical and intraluminal CRS does not interfere in ERK 1/2 and p38 activation profile in rabbit jejunum subjected to I/R.Item Anestesia intravenosa total com cetamina-propofol ou cetamina-xilazina-egg em infusão contínua em asininos pré-medicados com xilazina(Universidade Federal de Goiás, 2009-06-26) COELHO, Cássia Maria Molinaro; FIORAVANTI, Maria Clorinda Soares; http://lattes.cnpq.br/8772502020076257; ALVES, Geraldo Eleno Silveira; http://lattes.cnpq.br/2315947597632104; SILVA, Luiz Antônio Franco da; http://lattes.cnpq.br/0446055905975647The dissociative anesthesia was receiving more attention as the inhalation anesthesia based in cardiorespiratory and economic results in horses. However, there are few studies in donkeys (Equus asinus). The aim of this research was evaluate and compare the cardiorespiratory, metabolic and electrocardiographic effects of ketamine-propofol (KP) and ketamine-xilazine-EGG (GKX) total intravenous anesthesia in donkeys. Eight healthy adult donkeys were anesthetized twice with seven days interval between protocols. In both protocols, the animals were premedicated with 1.0 mg/kg of xylazine. The protocol KP was induced with 1.5 mg/kg of ketamine and a loading dose of propofol (0.5 mg/kg). The animals were maintained in constant rate infusion of ketamine (0.05 mg/kg/min) and propofol (0.15 mg/kg/min) during one hour. In GKX protocol, the animals were induced with diazepam (0.05 mg/kg) and ketamine (2.2 mg/kg). So, the animals were maintained in constant rate infusion (2 ml/kg/h) of a solution prepared with an association of 5% guaifenesin (100 mg/kg), ketamine (2.0 mg/ml) and xylazine (0.5 mg/ml). The quality of induction and recovery were assessed using scores (1-good; 2-regular; 3-poor) and measured cardiorespiratory, metabolic and electrocardiographic parameters before, during and after the anesthetic procedure. The results showed that the ketamine-propofol and ketamine-xylazine-EGG associations were satisfactory to anesthetized the donkeys, whereas seven anesthetic inductions were classified as good (score 1) in both protocols. The heart rate was statistic different between protocols since 15M moment. The mean arterial pressure decreased during the procedure in KP and GKX. There were no statistic differences between protocols in PaO2, PaCO2, LACv e LACa. The arterial glucose showed higher elevation in GKX and statistic difference at recovery. There were no statistic differences regarding CK and AST serum values. Concerning the electrocardiographic assessment, the protocols did not result in abnormalities on the length and amplitude of waves and complexes that could compromise the cardiac dynamics. In conclusion, propofol-ketamine and ketamine-xylazine-EGG associations can be successfully employed in asinines for the accomplishment of procedures without painful stimuli. The cardiorespiratory, metabolic and electrocardiographic changes observed in the present study were not sufficient to cause systemic distress in healthy animalsItem Avaliação histológica, histoquímica e imunoistoquímica da válvula mitral normal e com degeneração mixomatosa de cães e suínos(Universidade Federal de Goiás, 2009-10-29) CORREA, Leonardo dos Reis; ALVES, Rosangela de Oliveira; http://lattes.cnpq.br/5593911382353878; BRITO, Luiz Augusto Batista; http://lattes.cnpq.br/3212353728321020; MOURA, Veridiana Maria Brianezi Dignani de; http://lattes.cnpq.br/8773201078957745Myxomatous mitral valve degeneration (MMVD) or mitral valve endocardiosis is an endocardial age-related disease characterized by the mucopolysaccharide (MPS) accumulation and by collagen degeneration in mitral valves of many species, especially in humans, dogs and swine. Metalloproteinases (MMP) are proteolytic enzymes responsible for the extracellular matrix (ECM) remodelling in regular and pathological tissue. It has been suggested that the changing of the valvular distribution of these enzymes might be responsible for MMVD genesis. Likewise, vasoactive substances like nitric oxide (NO) played a role in the endocardiosis development. The aim of this study was to evaluate the histological changes, the expression of nitric oxide synthase (NADPH-d) and the immunohistochemical localization of MMP-2 and MMP-9 in the anterior leaflet in dogs and swine with regular mitral valves and those with endocardiosis. For this purpose, two experiments were done. First, 12 mitral valves of dogs and 22 of swine were analyzed. Valves were fixed in a 4% paraformaldehyde, exposed to NADPH-d reaction, processed routinely and microscopically evaluated for the detection of MPS deposition, collagen degeneration and fibrosis. In dogs, very high intensity reaction to NADPH-d was associated with higher endocardiosis degree and with presence of MPS deposition as well as collagen degeneration. There was no alteration in colour during the swine valves reaction to NADPH-d. In conclusion, NO works in canine mitral valves, remodeling MEC and playing a role in dogs mitral endocardiosis disease. In swine, it is suggested that NO has restricted action in MEC or there are major differences on the structures of swine valves because there was no reaction to NADPH-d and absence of macroscopical endocardiosis lesions. For the second study, 25 mitral valves of dogs and 32 valves of swine were also analyzed. Valves were macroscopically evaluated for the occurrence or not of endocardiosis. They were fixed in a 4% paraformaldehyde, routinely processed and submitted to immunohistochemical reaction and microscopically evaluated for the intensity of antigen labelling and for the number of positive cells, as well as MPS deposition, collagen degeneration and fibrosis. In dogs, DMVM is characterized by MPS accumulation. This collagen deposition and degeneration are directly related to the endocardiosis level. The MMP-2 and MMP-9 enzymes are involved in dogs myxomatous mitral valve degeneration process. In swine, even with the lack of microscopical endocardiosis there was observed some MPS deposition changes, especially in females. In these animals valves there are constitutive expression of MMP-2 and MMP-9, what suggests the action of these enzymes in the normal MEC mitral valvular remodeling in young and old female pigsItem Avaliação histológica e ultra-sonográfica de fígado de cadelas submetidas a programas de ganho e perda de peso(Universidade Federal de Goiás, 2008-11-27) COSTA, Rogério de Oliveira; FIORAVANTI, Maria Clorinda Soares; http://lattes.cnpq.br/8772502020076257; BORGES, Naída Cristina; http://lattes.cnpq.br/9181279951885005; ARAÚJO, Eugênio Gonçalves de; http://lattes.cnpq.br/3919777570059928The objective of this experiment was to evaluate the histology of livers of castrated bitches during sequential periods of weight gain and loss, through analysis of samples obtained by ultrasound guided biopsies. The experimental groups were composed by 30 bitches submitted to overweight by using of hypercaloric ration, from these animals were selected 14 to be submitted to two differents weight loss programs with seven receiving hypocaloric ration and seven receiving normocaloric ration. Periodic ultrasonographic analysis was employed to evaluate liver structure during the initial, obesity and weight loss stages, and revealed that none of the animals displayed altered images and no lesions at any stages. Histological examination revealed that no animals showed (0%) fibrosis or fat degeneration, 13 animals (92,8%) presented mild inflammation and one animal (7,2%) had severe inflammation. Nine animals (64,2%) did not have any kind of necrosis, four animals (28,5%) had mild necrosis and one animal (7,2%) had moderate necrosis. At the end of obesity stage, no animal showed fibrosis or fat degeneration and all 14 animals had mild inflammation. Ten dogs (71,5%) showed no signs of necrosis and four animals (28,5%) with light necrosis. Finally, in both groups in the weight loss stage no one animal (0%) with fibrosis, fat degeneration or necrosis and 14 animals (100%) with light inflammation. The group 2 had no animal had fibrosis, fat degeneration or necrosis and all dogs showed light inflammation. The results allowed the establishment of comparative parameters between ultrasonographic liver images and histological hepatic analysis in different stages of obesity and weight loss.Item ULTRASSONOGRAFIA DE ALTA FREQUÊNCIA PARA AVALIAÇÃO DO DESENVOLVIMENTO GESTACIONAL E DA FETOMETRIA EM CADELAS(Universidade Federal de Goiás, 2009-11-16) FERRARI, Marlon; ALVES, Rosangela de Oliveira; http://lattes.cnpq.br/5593911382353878; BORGES, Naída Cristina; http://lattes.cnpq.br/9181279951885005The monitoring and well care during the pregnancy is related to health born products. Considering that in canine reproduction the mate day is not a confident mark for fecundation because the sperm can be available during the estrus and the bitch can ovulate for seven to ten days and this can substimate the parturition day and the fetal growth. The knowledge of canine physiology and embryology during pregnancy and the pos partum associated of the correct application of diagnostic techniques help veterinarian to request for the best way to diagnose and chase the pregnancy. Physics examination, laboratory survey and imaging diagnostic are the principal tools for diagnose and prognoses of pregnancy. The image diagnostic is the most excellent technique to evaluate canine pregnancy. Radiographs and ultrasounds are accessible and can provide vital informations of the mother health and fetal development. This study s aim is to evaluate the morphological development of the bitch and fetus during pregnancy using high frequency transducer (12 MHz) and also compare the ability of the frequencies 7.5 MHz, 10 MHz and 12 MHz in measurements of fetal and extra fetal structures. To achieve this objectives it was scanned 25 bitch, two French bulldogs, one English bulldog, one American cocker spaniel, one lhasa-apso, two German sptiz, one Maltese, one pug, one schnauzer, two sheltland shepherd, ten shi-tzu and two Yorkshire terriers, weighting between three and 19 kilograms and age among two to six years from a commercial kennel, the animals were scanned by a unique examinator every seven days, the date day was used for mark the beginning of reproduction time, and the most near day of the date was the Zero week of scanning. The animals was follows by serial scanning and the events of the mother and the puppies were registered. The purpose of this study was to chase the pregnancy using high frequency transducer of 12MHz to determinate the period of appearance of fetal and extra fetal structures, which provides data s for parturition time and fetal maturity. The high frequency shows to be efficient for early diagnose of pregnancy, since was possible to identified the ovary and uterus with 2,7±2,1 days, gestational sac in 9,7±2,2 days of gestation, the embryos and heart beating were noticed with 16,7±2,2 days, the members arrows and bipolar shape appears in 23,7±2,2 days of pregnancy, fetal movement and de identification of the stomach were possible with 30,7±2,2 days, the bladder, skeleton, lungs and liver were visualized with 37,7±2,2 days, the kidney appears with 44,7±2,2 and pos partum uterus was identified with 65,7± 2,3days .Additionally contributing for seeking the fetal and extra fetal structures that provides security for estimation of parturiation date. Also was to propose a protocol of scanning to follow the preganancy period and pursue gestational diagnoses, fetal development and disorder during pregnancy comparing the ability of transducer of 7.5 MHz, 10 MHz and 12 MHz in the measurements and acoustic resolution. The gestation time was better avaluated in the second, fourth and seventh week, which shows the best protocol for track the pregnancy in the canine, additionally the high frequency demonstrate to improve the resolution and accuracy of measurements of fetal and extra fetal paramanters, but it not shows to be different from low frequency.Item Comparação da resposta imune induzida pela vacinação de bezerros Curraleiros e Nelores com Mycobacterium bovis-BCG.(Universidade Federal de Goiás, 2010-03-05) MAGGIOLI, Mayara Fernanda; KIPNIS, André; http://lattes.cnpq.br/4434965360286741; FIORAVANTI, Maria Clorinda Soares; http://lattes.cnpq.br/8772502020076257; KIPNIS, Ana Paula Junqueira; http://lattes.cnpq.br/1252262903952987Curraleiro breed has adapted to the extensive breeding in the Brazilian savanna. These rustic animals seem to be more resistant to regional endemic diseases. Resistance to infection is directly correlated to the host immune response. In order to check if differences might exist among Curraleiro s immune response and the response of other exotic cattle breeds in the savannah region, Curraleiro and Nellore calves were assessed before and after immunization with BCG vaccine. Twelve young calves (around six months of age) were used. After quarantine, the animals were divided into four groups: Control (three calves from each breed) and Vaccinated (three calves from each breed). The mononuclear cells were obtained from peripheral blood at time zero (before vaccination), one, seven and, thirty days after the vaccination. The cells were submitted to phagocytosis test, NO production and analysis by flow cytometry of the following populations: NK, T, CD4 e CD8 as well as for their IFN-production. The intradermic test was realized in all calves forty-five days after vaccination. Macrophages from Curraleiro breed showed superior phagocytosis rates (7.650±3.661) than Nellore macrophages (2.970±1.282). Before BCG vaccination, Curraleiro calves had higher numbers of CD4+ cells (2049±402.3), CD8+ cells (1207±166), TWC1+ cells (1443/mL±384,6) in peripheral blood, than Nellore calves (CD4: 1240/mL ±337; CD8: 772.1/mL ±278.3; TWC1+: 745.5/mL ±67.22). The CD4 and CD8 IFN- positive cells were also higher in Curraleiro animals. Vaccination was able to generate specific immune response on both breeds. Thirty days after vaccination, Curraleiro animals presented greater levels of CD4IFN-positive (202.8±44.96) cells than Nellore ones (143.7±40.43). The findings of this study support the Curraleiro resistance profile in comparison to Nellore breed, due to a better capacity to induce specific immune response to M. bovis-BCG vaccine.Item Ação Neuroprotetora do Extrato Etanólico da Casca de Pequi em Cérebros de Ratos Submetidos à Isquemia de Reperfusão(Universidade Federal de Goiás, 2011-03-24) MIGUEL, Marina Pacheco; BRITO, Luiz Augusto Batista; http://lattes.cnpq.br/3212353728321020; FIORAVANTI, Maria Clorinda Soares; http://lattes.cnpq.br/8772502020076257; ARAÚJO, Eugênio Gonçalves de; http://lattes.cnpq.br/3919777570059928Item Braçadeira de poliamida e fio de náilon na ovário-histerectomia em gatas(Universidade Federal de Goiás, 2012-02-24) PRADO, Tales Dias do; BORGES, Naída Cristina; http://lattes.cnpq.br/9181279951885005; ROZA, Marcello Rodrigues da; http://lattes.cnpq.br/6208651430407499; DAMASCENO, Adilson Donizeti; http://lattes.cnpq.br/3900110295277130Ovariohysterectomy is the most performed surgery in small animals, with the purpose of birth control, avoiding pseudocyesis as also treating female reproductive tract affections. Several surgery techniques have been described. Beyond the traditional midline approach to the abdomen, the flank many laparoscopic approaches may be performed. Twenty-four healthy, mongrel and adult cats took part of the study. They were randomly distributed in four groups of six animals, this way: GI midline approach and ligature with nylon thread; GII midline approach and ligature with nylon clamp; GIII flank approach and ligature with nylon thread and GIV flank approach and ligature with nylon clamp. The times of dieresis, ovariohysterectomy and closure were timed. Clinic evaluations were done at the day of the surgery and at 7 and 28 days after it. Ultrassonographic evaluations were performed at the day of the surgery, before and after it, and at 7 and 28 days after it, to verify possible alterations related to the material used. The results revealed that the midline approach was significantly faster than the flank approach. The ligature time of the pedicles and uterus body, as the total surgery time were statistically shorter for the groups that used the nylon clamp. We also observed a higher incidence of edema in the groups of midline approach at the seventh day after surgery, however at the twenty-eighth day after surgery, all the wounds healed equally. We concluded that the nylon clamps were secure to be use in cats ovariohysterectomies. Also, the flank approach takes more time to be performed than the midline one. The incidence of edema is considerable higher in the groups of midline access.Item Análise anatomo-funcional dos músculos do antebraço e a citoarquitetura do neocórtex occipital de Cebus libidinosus(Universidade Federal de Goiás, 2010-06-10) PRADO, Yandra Cássia Lobato do; FERREIRA, Tales Alexandre Aversi; http://lattes.cnpq.br/1101341437463729; DAMASCENO, Adilson Donizeti; http://lattes.cnpq.br/3900110295277130; ARAÚJO, Eugênio Gonçalves de; http://lattes.cnpq.br/3919777570059928Primates are known for larger brain size, enhanced handling and cognitive abilities and increasingly complex social behavior. Many studies have been conducted with the neotropical primates of the genus Cebus, known as capuchin monkey, regarding their behavior, tool use, encephalization index and memory. These studies are justified because these primates present high cognitive faculty and other biological characteristics that make them similar to Old World primates. This thesis rendered possible the production of two articles. The first one is entitled Anatomical description of the extensor muscles of the forearm associated with cognition and tool use in Cebus libidinosus . In this article, a comparative analysis between the anatomy of the forearm muscle of this genus and that the one of other primates that, individually or jointly, act in the hands allowing more or less specialized movements of the fingers, relating them to the use of tools and to the cognitive aspects of Cebus spp. described in the literature. There were evident similarities between the extensor muscles in C. libidinosus primates and the correspondent muscles in humans and chimpanzees; however, there were differences when compared to baboons. The structure and differentiation of the forearm muscles of Cebus spp., together with its previously known encephalization index, corroborate the association between its manual ability and cognitive and behavioral aspects in primates. The second article is entitled "Cytoarchitecture of the occipital neocortex of Cebus libidinosus . Its purpose was to analyze the cytoarchitecture of the occipital cortex using the technique of Golgi-Cox, the qualitative and quantitative aspects provided by this technique of impregnation of neurons, and to compare them with data from the literature. Primary and secondary visual areas are located in the occipital neocortex, and in C. libidinosus, the histological organization of these areas is similar to humans and other primates and it is characterized by the predominance of granular neurons and the presence of transversal fibers in the fourth layer. Although the Golgi-Cox method allowed individual observation of neurons and their extensions, the weak distinction between neurons and glial cells impaired neuron counting. These data, nevertheless, will grant further cell density comparison of other cortical areas between Cebus spp. and other primates. Aiming to contribute to the foundations of studies related to the evolution of primate cognition, this study related morphology, as a science, to the numerous observations on the behavior of capuchin monkeys. The comparative approach to study the morphology of the musculoskeletal and neural apparatus of C. libidinosus will allow data inference in areas of cognitive science and related areas.Item Ultrassonografia abdominal em quatis (Nasua nasua Linnaeus 1766) hígidos? descrição anátomo-topográfica(Universidade Federal de Goiás, 2012-02-16) RIBEIRO, Rejane Guerra; DAMASCENO, Adilson Donizeti; http://lattes.cnpq.br/3900110295277130; BORGES, Naída Cristina; http://lattes.cnpq.br/9181279951885005In the last years, the interest for the study of the Brazilian fauna s animals has been increasing considerably as a result of the risk of extinction or aiming for the control of the diseases, specially the zoonoses. The Coati (Nasua nasua) is an exclusive species of South America, classified as vulnerable in some states of Brazil. In spite of its large distribution and importance, the data about its ultrasonographic anatomy was not found in the literature. The use of ultrasonographic examination in veterinary medicine is largely disseminated as a way of complementary diagnostic because it offers, as a non-invasive way, information about the organs anatomy and morphophysiology. Although ultrasonography is a largely disseminated complementary diagnostic method in the clinical routine of little animals, there are few accounts in wild animals. The aim of this study was to describe, in a comparative way, the ultrasonographic features and the topography anatomy of coatis liver, kidneys, adrenal glands, ovarian, pancreas, gastrointestinal tract, urinary vesicle, spleen and uterus, and establish reference values to measure the kidneys, urinary vesicle wall and the gastrointestinal tract, contributing in this way with scientific material to the ultrasonography learn in this species. It has been used seven adult and healthy coatis originating from the Wild Animals Selection Center WASC, in which it was realized scannings and transversal, longitudinal and coronal cuts of all the abdominal organs being studied. It was verified that the abdomen ultrasonographic examination of the coatis can be realized following the one that is advocated for the dog and for the cat.Item SISTEMA DE BARREIRA COM FILME DE HIDROGEL DE POLI(2-HIDROXIETIL METACRILATO) NA PREVENÇÃO DE ADERÊNCIAS PERITONIAIS : ESTUDO EXPERIMENTAL EM RATAS E CADELAS(Universidade Federal de Goiás, 2009-01-16) SILVA, Marcelo Seixo de Brito e; FIORAVANTI, Maria Clorinda Soares; http://lattes.cnpq.br/8772502020076257; PAULO, Neusa Margarida; http://lattes.cnpq.br/7949273598509043Synthetic materials are the leading choice for the correction of defects in abdominal wall, but the formation of adhesions are a problem encountered when placing implants in contact with the abdominal viscera. With In order to avoid its formation, various materials and mechanisms are used in an attempt to prevent contact with peritoneal surfaces of the prostheses. In this sense, we investigated the possibility of the hydrogel poly (2-hydroxyethyl methacrylate) (polyHEMA) coating a face of polypropylene mesh and thereby preventing peritoneal adhesion in dogs and rats, and, in the latter species, also performed a histological evaluation of implanted materials. For this, an abdominal defect was created in the rectus abdominis of 16 bitches were divided into two groups of eight animals and the defect was corrected with screen polypropylene and polypropylene mesh coated with hydrogel, respectively. The presence of adhesions was evaluated after 20 days by laparoscopy. As to rats, the surgical procedure was similar and the evaluations were performed at 15 and 30 days, with euthanasia and collection of fragments for histology with picrosirius red staining and HE The hydrogel coating the polyHEMA polypropylene mesh implanted in the abdominal wall prevented completely visceral adhesions and omentum remaining on the surface the screen when compared to polypropylene mesh in dogs and isolated rats. Was found greater amount of adhesions in the suture zone in the group a mesh coated with polyHEMA. The physical structure of the biomaterial interfered the organization and persistence of tissue response, but not in the same type.Item Influência do estresse térmico no desempenho reprodutivo de vacas leiteiras no período voluntário de espera(Universidade Federal de Goiás, 2012-02-29) SILVA, Thiago Vilar; OLIVEIRA FILHO, Benedito Dias de; http://lattes.cnpq.br/6171669841505540; VIU, Marco Antônio de Oliveira; http://lattes.cnpq.br/7829414158162743; MEIRINHOS, Maria Lúcia Gambarini; http://lattes.cnpq.br/4440003524956701The aim of this work was to evaluate the total antioxidant capacity in Holstein cows during the volunteer waiting period on two moments, dry season and raining season, to correlate with variables: glucose levels, Na, K, Ca, AST, ALT, triglycerides, cholesterol, open days and services per conception. Were analyzed 60 animals, subdivided on two groups, dry period (n=30) and raining period (n=30). The experiment began at the calve (d0) and finished 42 days postpartum (d42), and the evaluations were weekly (d0, d7, d14, d21, d28, d35 e d42). The dry period showed THI=72,3 and raining period showed THI=75,9. The respiratory rate was different between the seasons (p<0,001) and within periods (p<0,01). The rectal temperature wasn´t between the seasons (p>0,05), but was different into the periods (p<0,05). The reproductive infections was presented in 56,6% (n=34), being 52,94% during the dry season and 47,05% during the raining season. There are different levels of glucose (p<0,05) between the seasons, less at the calve. The elements that were analyzed and showed more persistent variation was the cholesterol (P<0,05), AST (P<0,05), K (P<0,05) e Ca (P<0,05). The animals of the dry period had less open days (p<0,01) than the other group, but the services per conceptions weren´t significant (p>0,05). The Total antioxidant capacity (CAT) showed difference between raining season and dry season (p<0,05), with more elevated levels during the raining season. At the 42° day postpartum the animals with higher level of CAT had more open days than the others (r=0,37;p<0,05). The cows during the raining season appeared to be more stressed by the hot climate with more significant losses on the reproductive performance.Item Células-tronco mesenquimais na terapia de lesões tendíneas iatrogênicas de coelhos: obtenção, aspectos histológicos e ultraestruturais(Universidade Federal de Goiás, 2012-02-17) SOUZA, Luiz Augusto de; LACERDA, Elisângela de Paula Silveira; http://lattes.cnpq.br/9390789693192751; BRITO, Wilia Marta Elsner Diederichsen de; http://lattes.cnpq.br/7605775995731168; SILVA, Luiz Antônio Franco da; http://lattes.cnpq.br/0446055905975647Most tendon injuries are related to trauma and involve partial or complete tendon section due to the action of cutting or sharp objects or laceration. Recently, medical advances have shown a growing interest in the use of cell therapy for the treatment of chronic and degenerative diseases with slow and ineffective healing. The aim of this study was to establish a protocol for mononuclear cells isolation from bone marrow (BM) of rabbits, followed by purification using negative depletion with the monoclonal antibody CD45 for separation of mesenchymal stem cells (MSCs), with further cultivation in MesenCult ® medium. After that, it was evaluated the effects of allogeneic transplantation of MSCs with or without collagen extracellular matrix (CEM) on wound healing of the common calcaneal tendon in rabbits after partial tenectomy. Clinical, physical, macroscopic, histological and electron microscopy evaluations of tendon fibers were conducted. It was concluded that the collection, isolation, purification and rapid expansion of MSCs obtained from the mononuclear fraction of BM can be achieved using the density gradient Ficoll-paque®, negative depletion of haematopoietic cells in immunomagnetic base and MesenCult® medium. Furthermore, it was noticed that the number of passages exerts a negative influence on the morphology of the cells. Regarding treatment of tendinous injuries, the group treated with MSCs from bone marrow cultured in MesenCult® soaked in collagen sponge showed better results in terms of progress and quality of healing with deposition of collagen fibers in longitudinal orientation.Item Expressão de fator de crescimento transformador Beta e inibidores teciduais de metaloproteinases 1 e 2 em próstatas caninas normais e com lesões proliferativas(Universidade Federal de Goiás, 2012-03-08) TOLEDO, Denise Caroline; MENEZES, Liliana Borges de; http://lattes.cnpq.br/2012543423092393; BRITO, Luiz Augusto Batista; http://lattes.cnpq.br/3212353728321020; MOURA, Veridiana Maria Brianezi Dignani de; http://lattes.cnpq.br/8773201078957745The canine gland has drawn interest for research due to its similarities with the human prostate and the great incidence of lesions. Moreover, the canine prostate shows high incidence of diseases. The main lesions that affect the prostate are prostatitis, benign prostatic hyperplasia (BPH), cysts and adenocarcinoma. Recently attention has been given to lesions considered premalignant such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA), both studied in the human gland and also found in the canine prostate. In order to evaluate the development of prostate cancer starting as premalignant lesions, some immunohistochemical markers are employed, such as tissue inhibitors of metalloproteinases (TIMP), which have a key role in regulating the catalytic action of metalloproteinases (MMP), and transforming growth factor-β (TGF-β), that induces angiogenesis and inhibits cell proliferation and is considered a mediator of prostate growth. The objective of this study was to investigate the expression of TIMP-1, TIMP-2 and TGF-β in canine normal prostate tissue and with proliferative lesions. For this, 150 adult canine prostates were obtained from postmortem examinations. After microscopic evaluation 54 glands, compatible with normal, epithelial BPH, stromal BPH, PIA, PIN and adenocarcinoma were selected and used to make tissue microarray block (Tissue Microarray - TMA). TMA slides were subjected to immunohistochemistry with anti-TIMP-1, anti-TIMP-2 and anti-TGF-β, to assess staining intensity of epithelial cells and stromal cells.Cytoplasmatic staining of canine prostate cells by TIMP-1, TIMP-2 and TGF-β was observed, with TIMP-1 and TIMP-2 being more expressed in premalignant and malignant lesions, while TGF-β was expressed mainly by normal tissue and BPH. Furthermore, there were differences in the expression between epithelial and stromal cells.