FF - Faculdade de Farmácia
URI Permanente desta comunidade
Navegar
Navegando FF - Faculdade de Farmácia por Por Programa "Programa de Pós-graduação em Ciências Farmacêuticas (FF)"
Agora exibindo 1 - 4 de 4
Resultados por página
Opções de Ordenação
Item LQFM289: caracterização eletroquímica e computacional de um novo análogo da trimetozina para o tratamento da ansiedade(Universidade Federal de Goiás, 2024-12-21) Costa, André Gabriel Carmo; Macêdo, Isaac Yves Lopes de; http://lattes.cnpq.br/7801802836007488; Gil, Eric de Sousa; http://lattes.cnpq.br/3218622824233303; Gil, Eric de Souza; Santos, Pierre Alexandre dos; Rodrigues, Edson Sílvio Batista; Pereira, Eufrasia de SousaThis study employs electrochemical and Density Functional Theory (DFT) calculation approaches to investigate the potential of a novel analogue of trimetozine (TMZ) antioxidant profile. The correlation between oxidative stress and psychological disorders indicates that antioxidants may be an effective alternative treatment option. Butylatedhydroxytoluene (BHT) is a synthetic antioxidant widely used in industry. The BHT-TMZ compound derived from molecular hybridization, known as LQFM289 (Cabral et al., 2023), has shown promising results in early trials, and this study aims to elucidate its electrochemical properties to further support its potential as a therapeutic agent. The electrochemical behavior of LQFM289 was investigated using cyclic voltammetry (CV), square wave voltammetry (SWV), and differential pulse voltammetry (DPV), and a mechanism for the redox process was proposed based on the compound’s behavior. LQFM289 exhibits two distinct oxidation peaks: the first peak, (Ep1a ≈ 0.49V), corresponds to the oxidation of the phenolic fraction (BHT), and the second peak, (Ep2a ≈ 1.2 V vs. Ag/AgCl/KClsat), denotes the oxidation of the amino group from morpholine.Electroanalysis was used to identify the redox potentials of the compound, providing insight into its reactivity and stability in different environments. A redox mechanism was proposed based on the resulting peak potentials. The DFT calculation elucidates the electronic structure of LQFM289, resembling the precursors of molecular hybridization (BHT and TMZ), which may also dictate the pharmacophoric performance.Item Desenvolvimento de carreador lipídico nanoestruturado contendo filtro UV avobenzona(Universidade Federal de Goiás, 2022-09-30) Sousa, Isabelly Paula; Silva, Luís Antônio Dantas; http://lattes.cnpq.br/0999722983963121; Diniz, Danielle Guimarães Almeida; http://lattes.cnpq.br/6801755844853116; Diniz, Danielle Guimarães Almeida; Silva, Lorena Maione; Mendanha Neto, Sebastião AntônioIntroduction: Avobenzone (AVB) is an organic filter, acting in the ultraviolet (UV) A spectrum. It is a cosmetic ingredient that presents photo-instability, impairing its photoprotective activity. For AVB photoprotection, its molecule must be in conformation, however, exposed to a UV photoisomerization it undergoes, passing to a keto form, which has no protection against UVA radiation. Objective: To develop and characterize a nanostructured lipid carrier (NCL) containing AVB and to evaluate its photostability. Methods: The High Performance Liquid Chromatography (HPLC) method was validated to evaluate the AVB. The AVB compatibility with the selected components was the premeans evaluation of thermal analysis of spectrogravimetry and Fourier transformed infrared (FT-IR) porscopy. AVB solubility was for 24 hours by temperature test, under temperature of 37°C, for 24 hours. Afterwards, the components for the composition of the recommended formulation were selected as reasons according to the literature. For the maintenance of the CLN, the method of inversion of phases with application of microfluidization was used. To characterize the performance of the tests: preliminary stability for 14 days, average stability and follow-up of the formulation, evaluation of polydispersity, 30 days, evaluation of pH parameters, particle size, index index (Pd) and content. The encapsulation efficiency (EE%) was performed by the indirect method. The photo stable study lasted 24 hours and consisted of the evaluation of the NLC containing AVB under UVA radiation. The surface of the nanoencapsulated skin surface, AV was projected for 24 hours, using the Franz interface. Results and discussions: the studies of definition of average size, corroborate for the definition of the components of the CLN, isopropyl myristate, 80 and span 85. After the conclusion of the white CLN, the results of size and PdI of 145.9 ± 57 were obtained. .32 nm and 0.196 ± 0.04, respectively. When an AVB was incorporated into the CLN, 135.77 ± 7.27 nm of mean size and 0.150 ± 0.09 of PdI were obtained. For EE%, the value of 72.82± 1.81% of asset encapsulation was generated. Subsequently, the capacity test was performed, to which the solubilized AVB test was presented and the solubilized AVB presentation of solubilized AVB was presented and tested in how much AVB sampled the sample not presented to exposure. The AVB, did not show permeation of clothes in the skin CLN, having its actions in the skin of the CLN, having its skin. Conclusion: Thermal studies will allow the proper selection of formulation constituents. The functional treatment system developed, with protected CLN photo treatment features, and CLN photo treatment features protective conditions, thus, face to face UV. As for its safety, it is seen that the AVB remained mostly retained in the stratum corneum, it did not present permeation to the skin.Item Perspectivas em pesquisas sobre o gênero Campomanesia; estudos fitoquímicos e investigação de atividades biológicas em Campomanesia guazumifolia (Cambess) O. Berg - Myrtaceae(Universidade Federal de Goiás, 2022-07-05) Steckelberg, Rosa Maria de Brito; Paula, José Realino de; http://lattes.cnpq.br/3191837532986128; Paula, José Realino de; Cardoso, Cláudia Andrea Lima; Morais, Mariana Cristina deIntroduction: One of the challenges of public policies to encourage the use of herbal medicines is the inclusion of more native species, such as those of the Campomanesia genus, among the options for taking advantage of Brazilian biodiversity. Identifying research trends on the genus and species may arouse the interest of researchers so that more native species, such as Campomanesia guazumifolia (C.g) can be integrated into health systems where exotic species predominate. Objectives: To evaluate the scientific production of the genus Campomanesia and main species, especially C.g, in which the leaves of cultivated specimens were the object of pharmacognostic studies, phytochemical profile, essential oil characterization, antioxidant potential and biological activities. Methodology: Scientific production on the genus and species was evaluated using scientometric tools using the Web of Science database and the VOSviewer application. The experimental part consisted of traditional pharmacognostic studies; the essential oil was characterized by means of gas chromatography coupled to a mass spectrometer (GC-MS); the antioxidant potential was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method; larvicidal activity by mortality of Aedes aegypti L3 larvae and the antimicrobial activity was tested by a broth microdilution test. Results and discussion: Brazil leads research on gender and most of them occurred after the implementation of herbal medicine policies. C.g was the species with the highest proportional volume of publications in the last 5 years. The species presented flavonoids, tannins, saponins and triterpenes in its composition. The major compound of the essential oil (EO) was β-caryophyllene. The species showed good antioxidant (leaf extract and powder), larvicidal (EO) and antimicrobial activity, mainly against Candida sp and Micrococcus luteus strains. Conclusions: C. guazumifolia is a promising species for further research on biological activities and other studies that can support the traditional use and also as a phytomedicine.Item Validação de técnica analítica em LC-MS/MS para quantificação da ivermectina em plasma canino(Universidade Federal de Goiás, 2022-11-17) Toledo, Ney Ramos; Cunha, Luiz Carlos da; http://lattes.cnpq.br/6349547031976679; Cunha, Luiz Carlos da; Rodriguez Salazar, Vânia Cristina; Rodrigues, Caroline RegoIvermectin is an antiparasitary drug with endectocide activity, which is derived from avermectin, a macrocyclic lactone isolated from actinomycete Streptomyces avermectinus. This study aims to validate a new ivermectin’s analytical methodology, in dog plasma, with pharmacokinetic and bioavailability studies as objectives, regarding the still necessary clinical studies in dogs for veterinary products approval. Moreover, the optimized and developed method had as objective to have analytical benefits over the existent methods. The chosen analytical technique was High Performance Liquid Chromatography coupled to Mass Spectrometry (HPLC-MS/MS) with a Zorbax® C18 column from AgilentTM and, as mobile phase, 90:10 (Methanol:water) with 0,1% formic acid and 5 mM ammonium formate being added to aqueous and organic phases. The internal standard of choice was abamectin due to high similarity with ivermectin. Analytical validation was performed through a calibration curve with 7. Precision and accuracy intra-day and inter-day results were obtained through triplicate concentrations of quality control samples. Intra-day precision had 4,0 – 14,9% CV values and inter-day 6,4 – 11,6%. Intra-day accuracy had values between 95,0 and 114,61% and inter-day 98,1 and 109,0%. Stability studies had values between 88,8 and 98,2%. All results agree with parameters stablished by RDC nº27/2012. The analytical technique was used to determine ivermectin’s p.o. kinetic profile of a 2-year-old female mongrel dog weighting 14 kg, and proved adequate to quantificate typical concentration variations of pharmacokinetic data: Cmáx = 17,85 ng/mL; Tmáx = 1,00 h; AUC0-inf_obs = 2113,21 ng/mL*h; Vd = 41,24 L/Kg. The optimized and developed method had reduced use of organic solvents in its extraction method, faster analytical run, lower sample volume and can be used in pharmacokinetical studies.