Mestrado em Ciências da Saúde (FM)
URI Permanente para esta coleção
Navegar
Navegando Mestrado em Ciências da Saúde (FM) por Por Tipo de Defesa "Dissertação"
Agora exibindo 1 - 20 de 314
Resultados por página
Opções de Ordenação
Item Marcadores clínicos e laboratoriais no diagnóstico e gravidade da infecção pelo vírus da dengue em menores de 15 anos no município de Goiânia(Universidade Federal de Goiás, 2011-04-29) Abe, Adriana Helena de Matos; Costa, Paulo Sérgio Sucasas da; http://lattes.cnpq.br/9224543529268366; Costa, Paulo Sérgio Sucasas da; Franco, Cárita Marquez; Naghettini, Alessandra VitorinoIntroduction: Dengue is the most important emerging and reemerging disease in morbidity and mortality today. Among those affected. 2.5% die, and is increasing the number of deaths in children annually. In this group, in particular, early diagnosis is more difficult. Objectives: To identify clinical and laboratory markers for diagnosis and severity of dengue infection cases reported in the period 2001 to 2009 in children under 15 years old living in the city of Goiania, laboratory confirmed, describe sociodemographic data, tourniquet test and admissions performed. Methodology: Database Information System for disease surveillance of the City Health Department to Goiania was used to do a retrospective, descriptive, exploratory quantitative analysis, using the test of statistical significance t-student test, with significance level 5% and the final statistical analysis in SPSS 17.0. Results: In the period 2001 to 2009 were reported in the city of Goiania, 124,794 cases of dengue, of these 113,744 (91%), referring to residents of the capital. Among those under 15 years reported in this period, 22,278 were residents of Goiania. The tourniquet test was performed in 7428 (33.34%) of these children, 1,415 (6.36%) reported not having performed this test. 13,435 (60.30%), had this spot in blank and 1,222 (16.45%) were described as positive. Were documented 1043 hospitalizations of children in this period. Laboratory confirmation occurred in 10,756 cases. As a final classification was found 77% of Classic Dengue, Dengue with 7.4% of complications, 0.4% of Dengue Hemorrhagic Fever and 0.14% deaths, 15% were not classified. Among the laboratory markers found were registered 1,209 cases with IgM positive cases em108 DEN 1, DEN 2 in 14 cases and DEN 3 in 67 cases, Histopathology was cited positive in 4 cases, the hematocrit ranged from 21% to 81%, among the sociodemographic markers the race / ethnicity most marked in this population was white, children over 11 years were most affected, students complete basic education. The more clinical markers reported were fever, headache. myalgia, prostration; among hemorrhagic manifestations: petechiae and epistaxis; as signs of vascular leakage, ascites, pleural and pericardial effusion; warning sign most frequently reported were abdominal pain; the complications of gravity as myocarditis, shock and neurological manifestations have been reported among others. DEN 2 was the responsible for the highest number of severe symptoms. Conclusions: Were identified clinical markers for diagnosis and severity for Dengue in the period studied. The population of children showed severe signs of vascular leakage and neurological impairment. Despite the incompleteness of some data, it did not limit the study, which serves as the basis for a greater knowledge about dengue in children in this region.Item A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma(Universidade Federal de Goiás, 2016-11-16) Abreu, Fernanda Cruvinel de; Rabahi, Marcelo Fouad; http://lattes.cnpq.br/1489771770609266; Rabahi, Marcelo Fouad; Costa, Lusmaia Damaceno Camargo; Moreira, Maria Auxiliadora CarmoThe main goal of asthma treatment is to achieve and maintain clinical control of the disease. The exhaled fraction nitric oxide (FeNO) level is considered a biomarker of airways inflammation and its important to conduct researches involving this measured and its relationship in evaluation of asthma control.Objective: To determine whether the FeNO level can be used to discriminate between patients with controlled, partially controlled and uncontrolled asthma. Materials and methods: The FeNO level and asthma control were evaluated in a retrospective and analytic cross– sectional study through data collected from asthmatic patients who were assessed by clinical history, asthma control, physical examination, spirometry, and FeNO level. Asthma control was determined by the criteria of the Global Initiative for Asthma, and classified as controlled asthma, partially controlled asthma, and uncontrolled asthma. The FeNO values were classified as low (<25 ppb) or intermediate/high (≥25 ppb), based on the American Thoracic Society recommendations. Results: The symptoms of 81 asthmatic patients were classified as controlled (34 [42%] patients), partially controlled (27 [33,3%] patients), and uncontrolled (20 [24.7%] patients). The FeNO level discriminated between the uncontrolled and controlled groups (p = 0,01) and between the uncontrolled and partially controlled groups (p = 0,01), but not between the controlled and partially controlled groups (p = 0,98). An FeNO level >30 ppb was associated with uncontrolled asthma (p < 0,01) with an area under the receiver operating characteristic curve of 0,78 (95% confidence interval, 0,65-0,89). Conclusions: The FeNO level aided the identification of uncontrolled asthma. This measurement may can be helpful in determining asthma control.Item Alterações cognitivas em pacientes idosos com insuficiência cardíaca(Universidade Federal de Goiás, 2017-04-24) Afiune, Fernanda Guedes; Rassi, Salvador; http://lattes.cnpq.br/7236834842677715; Rassi, Salvador; Jardim, Paulo César Brandão Veiga; Barboza, Sandra de Fátima; Sá, Luis Antônio Batista deAmong the various diseases that affect the elderly stand out from them cardiovascular disease among them heart failure (HF). Recently seeks to check for cognitive impairment associated with physical and psychological damage commonly known in the IC. We analyzed a population of patients with heart failure in order to compare their cognitive performance with that of individuals with normal aging in paired age. It was also verified whether there was any more specific impairment of some cognitive function in these HF patients. Through neuropsychological tests it was compared to 78 elderly and 37 in the control group (mean age 68.3 ± 6.3), 41 clinical group with mean age of 68.6 ± 6.9). The subjects were matched to the level of education with a predominance of elderly people with 0-4 years of education (65.9% in the Clinical Group and 59.5% in the control group). We used 11 neuropsychological tests covering the cognitive functions: attention, language, memory, mood and executive function. The results showed significant differences mainly in executive functions which include planning capacity, organization, alternation and evocation of Previously stored information. Cognitive performance in other functions was similar between the groups. The data collected when indicating cognitive impairment in individuals with HF, suggest that new studies be performed with this population since the impairments in cognitive abilities have implications in the daily life of the individual, in their independence and quality of life, as well as in adherence to treatment.Item Implantação de uma Unidade Sentinela Centro de Referência em Medicina Internacional e de Viagem no Hospital das Clínicas da Universidade Federal de Goiás (HC / UFG)(Universidade Federal de Goiás, 2010-12-03) AIRES, Leticia Mara Conceição; GARCÍA-ZAPATA, Marco Túlio Antonio; http://lattes.cnpq.br/3672512339058369Introduction: The number of domestic and international travel has increased in past years. This way, Travel Medicine, has become an important subject, with the emergence of services that provide health care to travelers. Objective: To evaluate strategies used in deploying Sentinel Unit Reference Center for International and Travel Medicine at the HC / UFG. Methods: First approach: Systematic Review of Literature using the keywords: "Travel and medicine", "Travel and prevention", "Travel and Disease and Medicine" and "Traveler and medicine . Then were selected articles in English, Spanish and Portuguese, from 2004 to 2008. Second approach: a descriptive, qualitative and quantitative, with evaluation of actions taken during the period preceding the implementation of the Unit. Results: In the literature review were found 1,301 articles, and 72 included for analysis, we observed that malaria is the most studied disease, the main preventive measures discussed are chemoprophylaxis for malaria and vaccination. Health professionals working in Travel Medicine are general practitioners, pharmacists and nurses in various parts of the world, and among the obstacles we stress the lack of information in travelers, the lack of professional preparation and last-minute travelers. In a qualitative and quantitative research was performed a retrospective study in which differences were observed between physicians at the General Hospital and the tropical Diseases Hospital, where 1% of primary and 12.1% of the latter, asked about previous trips during office visits, and future study outlined profiles of health workers and travelers in their Knowledge, Attitudes and Practices in Travel Medicine, and noticed that 38% of professionals and travelers refer or seek treatment, although 91% of respondents consider it important to receive pre-departure orientation. Courses were held, symposium, lectures in education activities proposed. Travel Medicine now has code of regulation for public patients receive, and in 2009 and 2010 the Unit attended eight international travelers. Conclusions: The Travel Medicine faces many obstacles in Goiânia, as elsewhere in the world, being the main one the lack of information. We need a massive USCREMIVI disclosure to reach the objective of service to the traveler, in order of doing a situational diagnosis and to establish an educational facet.Item Overdenture retida por implante curto unitário em mandíbulas atróficas: estudo clínico prospectivo(Universidade Federal de Goiás, 2019-09-20) Ala, Lucas Alvarenga Balduino; Nogueira, Túlio Eduardo; http://lattes.cnpq.br/5622401475518280; Leles, Cláudio Rodrigues; http://lattes.cnpq.br/6740286066154410; Leles, Cláudio Rodrigues; Gonçalves, Thais Marques Simek Veja; Roriz, Virgílio Moreira; Santana, Adérico GuilhermeObjective: This prospective study aimed to evaluate the effectiveness of the use of a single short implant to retain single implant mandibular overdentures in atrophic mandibles. Material and Methods: Total edentulous individuals who had need to replace or put new complete dentures and who had reduced bone volume in mandibular symphysis region with a maximum height of 15mm for the installation of a short implant without need for bone augmentation procedures were selected. The clinical treatment was divided into three stages: I) protheses preparation; II) implant installation; III) installation of the overdenture system and of overdenture capture. Neodent Titamax Cone Morse implants (Curitiba – Paraná, Brazil) 3.75mm x 7.0mm was used, conventional loading protocol and Equartor CM retention system (Neodent, Curitiba, Paraná, Brazil). At the moment of implant placing, following clinical parameters were collected: implant stability quotient (ISQ), installation torque, bone type and ridge bone type Two outcomes reported by the patient were evaluated before to implant placement and 3 months after overdenture capture: prosthesis satisfaction and oral health impact on quality of life (OHIP-Edent). In addition, maintenance events related to the prosthesis were recorded during the follow-up period. Results: A total of 18 edentulous individuals with a mean age of 65.0 years (±12.1), 14 women (77.8%) were selected. The implant survival rate was 100%. The implant stability quotient (ISQ) increased significantly (p <0.05) after 3 months, from 72.7 (SD = 6.6) to 83.1. The overall OHIP-Edent score reduced in 82.3% and the mean score of patient satisfaction with the mandibular denture increased in 58.5% after 6 months. Conclusion: The use of a single short implant to retain a mandibular overdenture was effective after 6 months of follow up.Item Avaliação do perfil de resistência genotípica do HIV-1 aos antirretrovirais em crianças e adolescentes em falha terapêutica em goiás, no período de 2003 a 2015(Universidade Federal de Goiás, 2016-12-20) Albuquerque, Maly de; Araújo Filho, João Alves de; http://lattes.cnpq.br/3769452101687074; Costa, Paulo Sergio Sucasas; http://lattes.cnpq.br/9224543529268366; Costa, Paulo Sergio Sucasas; Marques, Solomar Martins; Turchi, Marilia Dalva; Vilela, Maria Ivone Oliveira PintoObjective: The aims of this study were to detect and identify drug resistance mutations through genotyping related to antiretroviral (ARV) resistance in children and adolescents infected with HIV-1 and with therapeutic failure. Methods: This was a descriptive study based on a retrospective cohort of HIV-infected children and adolescents diagnosed between 1992 and 2013. The pattern of ARV resistance mutations was analyzed in 65 children and adolescents, in therapeutic failure and followed up in a reference pediatric infectious disease clinic since diagnosis. A total of 92 genotypic resistance tests were carried out from 2003 to 2015. Genotypic tests were collected at the Central Laboratory (LACEN) and performed by the RENAGENO laboratory. For the interpretation of resistance the ARV algorithm was used (RENAGENO’s algorithm version 13th, 2015) and the Stanford’s algorithm (Stanford HIV drug resistance database, 2015). The study protocol’s was approved by the ethics committee of the HC / UFG and HDT / SES. Statistical analysis was performed with the software Microsoft Excel version 2010 and Statistical Package for the Social Sciences (SPSS®) 20.0 for Windows. Descriptive and inferential analyzes (t-Student and U-Mann-Whitney tests) were performed, considering the level of significance at 5%. Results: The sample consisted of 65 children and adolescents, with median age at diagnosis of 29.2 months (range from 2 months to 120 months); the majority was female (36/65). A total of 64 (98.5%) patients acquired HIV vertical transmission. Approximately 55% of the patients presented with severe immunosuppression at diagnosis of HIV, and 33% belonged to class B or C, according to the CDC-1994 clinical and immunological classification. The median baseline CD4 lymphocyte count was 921 cells/mm3. HIV viral load, before starting HAART, showed a median of 678,998 copies (log 5.83). At the time of first genotyping, CD4 ranged from 1 to 2940 cells/mm3, with a median of 608 cells/mm3, with a median of 40,548 copies/mL (log 4,60). Most mutations were found in the NRTI class (98.5%), followed by NNRTI (75.4%) and PI (44.6%). The most frequent mutations in the NRTI class were T215 codons (83.1%), with prevalence of T215YF (69.2%), M184V (69.3%), and M41L (52.3%). The most observed mutations in the NNRTI class were K103N / S (40.0%), 190A / S (30.8%), 101E / P / Q (23.1%). Mutations associated with resistance in protease occurred mainly in codons 54, 82 and 46, with rates of 35.4%; 32.3%; 27.7%; respectively. Resistance to more than one class occurred in 41.5%, 12.3% and 35.4% with the combination of NRTIs and NRTIs, ITRN + IP / r, and with the three NRTI + NRTI + IP classes respectively. After rescue therapy, approximately 90% of the patients analyzed had viral suppression, with HIV viral RNA levels below the detection limits (<50 or 40 copies) after 24 weeks of change in the combined antiretroviral regimen (P <0.001). Immunological response resulted in benefit, with significant elevation in CD4 + T cell count (P <0.001). Conclusions: Our study provided relevant information on the results of the genotypic resistance test after failure of long-term ARV therapy in children and adolescents infected with HIV. There were high mutation rates in all antiretroviral classes tested. Rescue therapy guided by the genotypic test provided high rates of viral suppression. Thus, the genotype test emphasizes the possibility of adequately composing an ARV regimen, with a high genetic barrier, using the new drugs and new classes of ARV drugs, with the objective of avoiding the therapeutic failure after rescue and preventing the accumulation of other mutations related to drug resistance.Item Associação entre hematúria no EAS e a RNI em pacientes anticoagulados com varfarina(Universidade Federal de Goiás, 2013-10-15) Almeida, Ely Rodrigues de; Cunha, Luiz Carlos da; Cunha, Luiz Carlos da; Salazar, Vânia Cristina Rodrigues; Alcântara, Keila Correia de; Costa, Paulo Sérgio Sucasas da; Costa, Sérgio Henrique NascenteINTRODUCTION: Anticoagulation with warfarin is used in the presence of hypercoagulability and as prophylaxis for thromboembolism. Prothrombin time and activity and the international normalized ratio (PTA/INR) are the standard tests for laboratory follow up of the anticoagulation rate. Hemorrhage is one complication of this therapy. Therefore, one speculates on the possibility of diagnosing cases in which there is excess anticoagulation, by means of the analysis of hematuria in urinalysis and the association with PTA/INR. OBJECTIVE: Analyze the existence of a correlation between hematuria in urinalysis and high PTA/INR, among users of warfarin. METHODOLOGY: This is a descriptive, analytical, primary, quantitative and cross-sectional investigation. The study included 128 patients, 63 of whom were being treated with warfarin, and formed the group of anticoagulated patients (ACG). The remaining 65 patients who were not using anticoagulants formed the non anticoagulated group (NACG). For this study, 152 blood and urine samples were collected; 24 patients of the ACG contributed twice for the PTA/INR and urinalysis, at two different times. All the participants of the NACG also had the PTA/INR and urinalysis tests done. Patients with a clinical suspicion of conditions that might cause hematuria were excluded. The social and demographic data of these individuals were analyzed and the numerical variables of hematuria and of other urinalysis and INR parameters were measured and analyzed. The prevalence and the correlation between hematuria and PTA/INR levels were calculated. Data from the tests, medical appointments and the records of patients recruited in the collection room of the Clinical Laboratory of the HC-UFG were evaluated statistically, and emphasis was placed on the Spearman's correlation for hematuria and PTA/INR (IC 95%; p< 0.05). The study was approved by the Committee on Ethics and Human Research of the HC-UFG, protocol No. 016/2012. RESULTS: The amount of warfarin given on a weekly basis ranged from 10 to 65 mg. If one considers the INR between 2 and 3.9 acceptable for adequate anticoagulation, 59.77% of the individuals were adequately anticoagulated, 35% were insufficiently anticoagulated and 5.75% were excessively anticoagulated. The prevalence of hematuria among the ACG members was 26.44 % (CI 95% 17.98 – 36.43) and among NACG members, 29.23 % (CI 95% 19.16 – 41.11). The correlation coefficient between hematuria and INR was 0.012 (p=0.887). CONCLUSIONS: The most of the patients (59.7%) were within the recommended therapeutic range for controlling patients. There was no correlation between hematuria as measured by urinalysis and anticoagulation levels measured by the INR.Item Perfil epidemiologico das neoplasias do colo uterino (in situ e invasoras) diagnosticadas na cidade de goiânia: análise de 17 anos (1988-2004)(Universidade Federal de Goiás, 2010-10-28) ALMEIDA, Fábio Marques de; MOREIRA, Marise Amaral Rebouças; http://lattes.cnpq.br/6390358577348486Determine the epidemiological profile of in situ and invasive neoplasias of the uterus cervix in Goiânia during the period from 1988 to 2004. Methodology: The cases were identified in the Population Base Register of Cancer database of Goiânia. The studied variables were: age, histological type, extension of the disease and mortality. Analysis was done by central tendency in which the incidence rates were calculated by age, extension of the disease using Census population data and the standard population of Segi; for the mortality analysis the data were extracted from Mortality Information System. Results: We identified 4446 cases of in situ and invasive neoplasias of the uterus from the period of 1988 to 2004. Histopathology was used in 91,9% of the cases; average age was 40 years old for the in situ neoplasias and 52 years for the invasive ones (DP ± 13 and 14 years old, respectively). There were 2213 (58,28%) in situ cases, 1603 invasives (41,8%) and, in 633 cases (14,2%), it was not possible to verify their extension. The annual rate of percentage change (AAPC) for the in situ incidence was 13.08% (IC 95% 9.75 16.50; p<0.0000) per year and1.27% (IC95% -1.74 4.37; p<0.3862) for the invasive cases. The standard mortality rate was 12.2 and 8.2 per 100,000 in 1988 and 2004 respectively, with an AAPC of -3.02 (IC95% -5,36 -0,62; p<0,0172). Squamous cell carcinoma was found to be the predominant histologic type. A reduction of the Adenocarcinoma incidence in situ was not found nor was found a significant change of the Adenocarcinoma invasive; the squamous invasive cancer did present a considerable reduction of 2,85 per year. Conclusion: It was observed that the most frequent invasive tumors were the squamous cell carcinomas and Adenocarcinomas. Data did not demonstrate a rise in the diagnosis of invasive neoplasia, although there occurred an increase of diagnoses of in situ neoplasias. Mortality has demonstrated a tendency of reduction, suggesting that improvements of the tracking programs have changed the incidence or uterine cancer, though it has not yet accomplished all its objectives. Keywords: cervical cancer, uterus, epidemiology, frequency, extension, incidence, Goiânia, Brazil.Item Capacidade funcional de idosos com vertigem posicional parxística benigna(Universidade Federal de Goiás, 2010-10-18) ALVARENGA, Gabriella Assumpção; BARBOSA, Maria Alves; http://lattes.cnpq.br/5025797873585225; PORTO, Celmo Celeno; http://lattes.cnpq.br/9673684282497548Dissertation built modality scientific article. In the first article submitted to "Journal of Otolaryngology" with the title benign paroxysmal positional vertigo without nystagmus: diagnosis and treatment, there was a literature review, using the following keywords: "dizziness / vertigo, diagnosis / diagnosis, therapeutic / therapeutical approaches. " Scientific publications are included in the period 2001-2009 in Portuguese, English and German. We found nine papers dealt with BPPV without nystagmus, whose diagnosis was based exclusively on clinical history and physical examination. The treatment of BPPV without nystagmus was made by Epley maneuvers, Semont, discharge modified for posterior semicircular canal and Brandt-Daroff exercises. All show that 50% to 97.1% of patients with BPPV without nystagmus, had remission of symptoms, while patients with BPPV nystagmus with remission of symptoms ranged from 76% to 100%. Hence one can conclude that the differences may not be significant, which demonstrates the need for further studies on BPPV without nystagmus. In the second paper, Functional Capacity of Elderly with benign paroxysmal positional vertigo, compared the functional capacity among elderly patients with BPPV and elderly without clinical diagnosis of BPPV and that / or dizziness or vertigo, identifying the physical activities of daily living and instrumental activities of daily living in elderly people in both the Group of Elderly with BPPV (EBPPVG) and Control Group (CG). This is a cross-sectional study, case-control study in Hospital Geral de Goiânia (HGG), with the participation of 14 elderly patients with a diagnosis of BPPV and the Programa de Gerontologia Social / Universidade Aberta à Terceira Idade (UNATI) from the Pontificia Universidade Católica de Goiás (PUC-GO), with the participation of 13 subjects without dizziness or vertigo and / or clinical diagnosis was of BPPV. Functional capacity was assessed by the subscale of the Functional Assessment Questionnaire Brazilian Multidimensional Functional Capacity / Operating Older American Resources and Services Multidimensional Functional Assessment Questionnaire (BOMFAQ/OARS), verifying that the difficulty in performing 15 activities of daily living (ADL), eight physical activities of daily living (AFVD): throw / out of bed, eating, combing hair, walk on the plane, bathing, dressing, going to the bathroom in time and trimming toenails, and seven instrumental activities of living daily living (IADL): climbing stairs (one flight), doctor-on time, walk close to home, shopping, preparing meals, driving out and do house cleaning. Arrived at the following conclusions: a) elderly people with BPPV showed a statistically significant lower functional capacity than subjects without this diagnosis, b) in EBPPVG, the average number of daily activities (physical and instrumental), those with difficulty was 6.53 with a maximum of 11 activities committed while in the CG, the average impairment was 0.86 with a maximum of 4 activities referred with difficulty in performing c) EBPPVG affected performance in 13 activities of daily living, including physical seventh floor in the plan, bathing, dressing, combing hair, going to the bathroom in time, bedtime and getting up from bed or chair and cut nails feet, and 6 which are instrumental, climbing stairs, walking around the house, shopping, preparing meals, driving out and do house cleaning in the comparison between groups, d) Activities that were cited as the most difficult among the elderly were similar in both groups. However, the degree of impairment, characterized in: without commitment (when the elderly did not report any difficulty in any of the 15 evaluated ADL), mild (1 to 3 activities impaired), moderate (4-6 impaired activities) and severe (for seven or more impaired activities) was significantly higher in EBPPVG, where 7 (50%) showed severe impairment in ADL performance.Item Prevalência de fatores de risco para doenças cardiovasculares e consumo de energia e nutrientes de adultos e idosos ativos e inativos(Universidade Federal de Goiás, 2015-11-30) Alves, Ana Gabriella Pereira; Silva, Maria Sebastiana; http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4791881D6; Silva, Maria Sebastiana; Hadler, Maria Claret Costa Monteiro; SIlva, Maria ReisIntroduction: Cardiovascular diseases (CVDs) are one of the most important cause of death in Brazil and the world, and it is known that poor diet and physical inactivity are strongly associated with its prevalence. However, the relationship between the risk factors for CVDs with the food intake and physical activity is not fully clarified. Objective: Identify the prevalence of risk factors for CVDs in active and inactive adults and elderly people from a Brazilian city and associate them with food intake. Methods: A cross-sectional study was conducted with the people attended by the Family Health Strategy of Santo Antônio de Goiás (GO), Brazil. Socioedemographic (gender, age, marital status, education and individual income), lifestyle (smoking and drinking), blood pressure, physical activity, anthropometric [body mass index (BMI), waist circumference (WC) and body fat percentage (BF%)] and dietary intake data were collected and evaluated. Categorical variables were expressed as relative frequency. Pearson’s qui-square test was used to compare both the prevalence of risk factors for CVDs as the adequacy of food consumption between active and inactive people. Independent-samples t test and Mann-Whitney test were used to compare de anthropometric variables, blood pressure and dietary intake between active and inactive individuals. Binary logistic regression was used to determine the association of BMI, WC, BF% and hypertension with dietary intake, adjusted and not adjusted for age group and sex. P < 0.05 was considered significant. Results: Of the 83 participants, 61.4% were active and there was no difference in the prevalence of risk factors for CVDs, anthropometric data, blood pressure, estimated energy requirements and energy and nutrients intake between active and inactive (p ≥ 0,05). Besides, there was no difference in the prevalence of energy and nutrients intake adequacy between groups (p ≥ 0.05). It was observed in the inactive people that the total (OR: 1.021, p = 0.035) and saturated (OR: 1.060, p = 0.033) fat consumption increased the odds of being overweight, with no relationship between dietary intake and risk factors for CVDs when considering all participants or active subjects (p ≥ 0,05). The adjustment for age group and sex did not influence the test results. Conclusions: There was no difference in the prevalence of risk factors for CVDs between active and inactive people, but the consumption of total and saturated fat increased the chance of overweight among inactive subjects.Item Fatores de risco cardiometabólicos e aptidão cardiorrespiratória de mulheres assistidas pela Estratégia Saúde da Família de Santo Antônio de Goiás: um estudo transversal(Universidade Federal de Goiás, 2016-03-09) Alves, Fagner Medeiros; Soares, Viviane; http://lattes.cnpq.br/6159347922714347; Silva, Maria Sebastiana; http://lattes.cnpq.br/1329422634395496; Silva, Maria Sebastiana; Soares, Viviane; Rebelo, Ana Cristina SilvaThe metabolic syndrome is characterized by the presence of three or more cardiometabolic risk factors and there is evidences of its association with low cardiorespiratory fitness. Despite the variety of studies that investigated the relationship of metabolic syndrome with cardiorespiratory fitness, there is still a shortage of studies, especially national, who analyzed with density the risk factors of disease with ventilatory variables obtained by cardiopulmonary exercise testing. Another fact which justify the importance of this study is achievement of analysis in tertiles from test time and ventilatory variables that will locate and stratify risk groups, that is, find the range of ergospirometric variables that focus individuals who are at increased risk. Objective: To evaluate the relationship of risk factors of metabolic syndrome with cardiorespiratory fitness of women. Methods: Cross-sectional study with 73 women (20-59 years old) attended by the Family Health Strategy of Santo Antônio de Goiás, Goiás, Brazil. Blood samples were collected for the measurement of biochemical parameters and, together with anthropometric and hemodynamic was diagnosed the metabolic syndrome. Cardiorespiratory fitness was assessed by cardiopulmonary exercise test with progressive exercise protocol. The relationship of metabolic syndrome indicators with cardiorespiratory fitness was analyzed by one-way ANOVA and multiple linear regression adjusted for age. Results: The frequency of metabolic syndrome was 53.3% among women. All had at least one risk factor for the disease. We found a significant association of peak oxygen consumption and test time with waist circumference and systolic and diastolic blood pressure. Waist circumference was related to peak oxygen consumption (β = -0.50, CI -0.21, -0.06), ventilatory threshold (β = -0.37, CI -0 12, -0.16), test time (β = -0.47, CI -0.09, -0.03) and this was also associated with fasting glucose (β = -0.31, CI -0.03, - 0.001). Conclusion: We demonstrated a high frequency of metabolic syndrome, as well as the presence of at least one cardiometabolic factor. Through tertiles was identified intra-group variability in the relationship of abdominal adiposity with cardiorespiratory fitness parameters and a significant relationship between increased levels of abdominal adiposity and reduced cardiorespiratory capacity.Item Impacto da educação permanente dos profissionais de saúde no rastreamento do câncer do colo do útero em unidades básicas de saúde(Universidade Federal de Goiás, 2014-03-14) Amaral, Ariadne Ferreira; Tavares, Suelene Brito do Nascimento; http://lattes.cnpq.br/9547970481617204; Amaral, Rita Goreti; http://lattes.cnpq.br/3665611660713029; Amaral, Rita Goreti; Guimarães, Janaína Valadares; Ferreira, Tatyana Xavier Almeida MatteucciThe quality of cytopathology womb cervix test is important to ensure the functionality of an organized screening program. Objectives: Evaluate the impact of training of health professionals involved in the screening for cervical cancer in basic health units. Methods: Intervention study developed based on information from the requisition forms of cytopathology tests of women attending seven basic health units in the city of Goiânia-GO. The variables were the woman personal data, anamnesis, clinical examination and the identification of responsible professional for the collection, in the request form for the cytopathology womb cervix test. 21,344 requisition forms were analyzed, of these, 10,672 forms are related the period from January 2007 to April 2009, before the training, and the other 10,672 are for the period July 2010 to December 2012, after the training. Evaluating the impact of training was conducted by comparing the information contained in the requisition forms of cytopathology tests. The training conducted with health professionals was related to filling in the requisition form, collection of cytopathology test, adequacy of the sample, representation of the epithelium and conducts clinics for screening of cervical cancer having as reference the standards of the Ministry of Health. To evaluate the results of the training we used a Pearson chi-square test with significance level p < 0.05. Results: After the training there was a significant increased frequency of school completion, from 67.2% to 92.6% (p < 0.001), the telephone from 78.9% to 98.7% (p < 0.001). Cervical inspection from 86.8% to 96.6% (p < 0.001), and STDs suggestive signs, from 80.8% to 93.5% (p < 0.001). There was a reduction in the exam frequency of less than one year (p < 0.001) and one year of intervals (p < 0.001). There was a reduction in the frequency of Pap smear testing in women under 25 years of age, from 22.0% to 17.9% (p < 0.001). There was a significant increase in the proportion of satisfactory samples from 70.4% to 80.2% (p < 0.001). It was observed a reduction of obscuring factors. The desiccation frequency was 2.9% before training and 2.0% after training (p < 0.001). There was an increase in the frequency representation of endocervical cells from 79.5% to 88.5% (p < 0.001).Conclusions: After the training conducted with health professionals observed a significant improvement in completing the requisition form and Pap smear testing as the frequency and age, recommended by the Ministry of Health. Regarding the Abstract adequacy of the sample there was an increase of satisfactory samples, reducing obscuring factors and better representation of squamous and glandular epithelium.Item Avaliação da deglutição de pacientes em um centro de referência em esclerose múltipla no centro oeste do Brasil(Universidade Federal de Goiás, 2016-11-09) Amaral, Inez Janaina de Lima; Guimarães, Valeriana de Castro; http://lattes.cnpq.br/6222102545181441; Guimarães, Valeriana de Castro; Diniz, Denise Sisteroli; Barros, Ana Paula Brandão; Brito, Alessandra ReginaThe control of the symptoms of dysphagia in patients with Multiple Sclerosis (MS) has been underestimated by clinicians, patients and caregivers. Dysphagia has a prevalence between 33-43% of this population. The evaluation of the swallowing has been a major challenge in clinical practice, and without a unified method of diagnosis in this population. Identify patients with dysphagia in the early stages of MS is fundamental in preventing complications such as malnutrition, dehydration and death. The aim of this study was to identify the presence or absence of swallowing desorders in patients diagnosed with MS in the Reference and Research Center for Multiple Sclerosisin the University Hospital of the Federal University of Goiás, in the midwest of Brazil. This was a cross-sectional study between july 2015 and march 2016, with 73 patients above 18 years old with definite diagnosis of MS. It was excluded patients from other health units, outside the scope of the suty period, without clinical conditions associated with other diseases or who did not agree to participate. The presence of dysphagia was found at 30.14% of the patients. This finding meets the results in other studies. The main manifestations were dificulties in qualifying and propel the food bolus, with changes in the oral and pharyngeal phases of swallowing. Thus, it is necessary the evaluation and monitoring of this population, guarateeing early intervention, reducing the risks to the quality of life.Item Avaliação da disciplina de técnica operatória por estudantes do curso de medicina da Universidade Federal de Goiás(Universidade Federal de Goiás, 2017-02-14) Andrade, Elson Gonçalves de; Melo, Renato Miranda de; http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4735652Y8; Oliveira, Ênio Chaves de; http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785665U2; Oliveira, Ênio Chaves de; Penhavel, Félix André Sanches; Melo, Renato Miranda de; Gabriel Neto, SalustianoIntroduction: Medical education needs to go through reflections regularly so that we can reflect on what kind of professionals and that profile is required for adequate preparation to the labor market. So it is important not only ethical reflection and technology, but also in the way you learn the disciplines of medical training. A realistic assessment should include a participatory assessment of satisfaction that can enable the debate between servers - teachers and técnicos-, but as well as students who are the most important link - if not essential - the reason for the existence of the University. Objectives: To analyze the level of satisfaction of the students of the Faculty of Medicine, Federal University of Goiás in relation to discipline Operative Technique, focusing on satisfaction with the teachers attitudes, perception of infrastructure, equipment and human resources, as well as teaching teaching the surgical technique of discipline on the menu. Methods: it was initially performed a literature review concerning the Brazilian educational guidelines about the area and operative technique as well as the latest research in the last 10 years, based on the database between the years 2003-2015. Then was administered questionnaire with Likert Scale duly registered with the Committee of Ethics in Research of the UFG and Platform Brazil students from the Technical discipline operative in the last school month. Data from 71 students were then stored in spreadsheets and analyzed using Epi-Info 7.1. After analysis of the data was carried out discussion of the data obtained and compared with the existing literature and characterize the level of students' satisfaction with the surgical technique of discipline. Results: it was found that most of the students are female, aged 20-21 years old who spend up to 2 hours weekly to study the subject and 64.8% only sometimes refer to literature indicated. It was also observed that the discipline of Operative Techniques attended the expecatativas of 85.91% of students and 88.73% positively evaluated the discipline. The evaluation area Infrastructure Course and Instructional Resources, obtaining the highest dissatisfaction frequencies at level 1 and level 2 by the students. Conclusion: It is suggested the need to update the bibliography indicated on the menu of course, recommending also the need for greater investment in physical facilities of discipline and improvements in the area observed a positive satisfaction rating at the level of excellence for the area assessment human resources, indicating the maintenance of the monitoring program in the discipline as well as the performance of technical and administrative staff and especially the qualification of the teaching staff, which was the most highly rated by students with 95.78% satisfaction positive.Item Obtenção de carreadores lipídicos nanoestruturados contendo clobetasol e tacrolimus e avaliação da permeação cutânea(Universidade Federal de Goiás, 2014-02-26) Andrade, Lígia Marquez; Taveira, Stephânia Fleury; http://lattes.cnpq.br/0382450621383005; Taveira, Stephânia Fleury; http://lattes.cnpq.br/0382450621383005; Marreto, Ricardo Neves; Gratieri, Tais; Diniz, DanielleThe use of topical medications, such as clobetasol propionate (CLO) and tacrolimus (TAC) is the main treatment for inflammatory skin diseases including discoid lupus erythematosus (DLE). The DLE is a chronic disease that affects the skin and its treatment can be improved with the simultaneous use of these drugs. However, this condition is difficult to treat topically because of the thickening of the stratum corneum (SC). New formulations such as lipid nanoparticles and the use of permeation enhancers can improve drug penetration in the skin and improve the topical treatment of different pathologies. Therefore, the aim of this study was to develop and characterize nanostructured lipid carriers (NLC) containing TAC and CLO and NLC coated or not with chitosan oligosaccharide (CO), in order to increase the skin permeation and retention of drugs. NLCs were prepared by the dilution of the microemulsion and were subsequently coated with OQ. The carriers obtained contained both drugs or TAC or CLO separately. The formulations obtained were evaluated for average diameter and polydispersity index (PDI), zeta potential, drug recovery (DR), encapsulation efficiency (EE) and drug loading (DL). The drug penetration from the NLC was assessed in pig ear skin in Franz cells. Co-encapsulated NLCs showed an average diameter of 143.3 nm and PdI of 0.264. The particles showed negative zeta potential of about -40 mV. After coating with OQ, NLCs showed a significant increase in diameter (311.9 nm) (p <0.05) and positive zeta potential (24,4mV) due to the adsorption of CO on the surface of the NLC. Co-encapsulation of the drug was effective, EE was greater than 90% for both TAC and CLO. In studies of electron paramagnetic resonance (EPR) it was observed that the drugs slightly modified the dynamics of lipids in NLC on the surface of the matrix (5-DSA). There was a significant increase in the 2A// parameter, the TAC+CLO-NLC (47,1G) compared to NLCs with no drug (45,6G). When the samples were coated with CO, the lipid dynamic modified considerably. The 2A// values increased from 45.5 to 50.1 in the NLC and 46.5 to 50.7 in the TAC+CLO-NLC. The CO probably forms a frame around the nanocarriers which significantly reduces the lipids mobility. The encapsulation of the drugs increased penetration of both TAC and CLO to the skin layers when compared to non-encapsulated drugs. The NLC coated increased the amount of TAC retained in the deeper layers of the skin (approximately 1.8 times more drug). For the CLO, the coating favored retention in the EC (1.7 fold) and on the remaining skin (3 times more drug) as compared to uncoated particles. When co-encapsulated with TAC and CLO, TAC’s penetration was superior compared with the particle containing only TAC. Thus, this strategy has shown to be promising to increase TAC’s skin penetration , which is a drug that hardly passes through the SC and promote greater retention of CLO in the upper layers of the skin. The results suggest that the co-encapsulated system is a potential formulation for skin drug delivery of the drugs.Item Perfil sociodemográfico e sentimentos vividos gestantes com malformação fetal(Universidade Federal de Goiás, 2014-11-29) Andrade, Margareth Novais de; Amaral , Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Costa Neto, Sebastião Benício da; Ferreira, Rui GilbertoThe diagnosis of congenital anomalies brings some consequences to the life of pregnant women. One of them is related to the emotional aspect. The social support connection between patient and multi-professional team reveals to be one of the fundamental strategies to reduce the incidence of aggravations to the health of the pregnant women, considering the fact that, from that, they begin to be monitored by a variety of professionals in different fields of study. Goals: Rework theoretically the most important aspects on the studies of congenital malformation and the feelings lived by those pregnant women; Embrace, from the active research of the patients taken in the Fetal Malformation Ambulatory of the Hospital das Clínicas da Universidade Federal de Goiás, the feelings most common in the post-diagnostic of fetal deformity and characterize them social and demographically. Methods: Initially, it was developed a literature rework article. On the article, some data was used as reference, such as: Pub-Med, Wiley on Line Library, Science Direct, Scientific Electronic Library Online (SciELO) e Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), and also publications from the period within 1984 and 2013. Later on, a documental research in the database of the Fetal Malformation Ambulatory of the Hospital das Clínicas da Universidade Federal de Goiás, in order to gather the information needed on the location of theses taken patients by that ambulatory, was developed. A set of questions were applied to 74 patients, who carried fetuses with anomalies, seen by the ambulatory before mentioned, within the years of 2012 and 2013, the documents were, then, systematized and analyzed. From the results gathered, an article was compiled on the feelings lived by the women that carried fetuses with anomalies, as well as the characterization from the social and demographical prisms. Results: It was verified on the literature rework that the multi-professional team’s performance on the pregnancy is fundamental to reduce the suffering of these women. The pattern established of the pregnant women seen at the Fetal Malformation Ambulatory can be defined as: the majority is in the age group between 20 and 30 years old, Caucasian, and with income up to a minimum wage. The majority was also legally married, had already had another child, had been to approximately 6 antenatal care appointments and graduated from high school. The most frequent feeling was fear, followed by sadness, insecurity and doubt over the diagnosis. Conclusion: The diagnosis of fetal malformation raises the perception of the emotional suffering, which shows the relevance and the necessity of the work developed by a multi-professional team.Item Avaliação da inicialização da marcha na gestante de baixo risco nos três trimestres gestacionais(Universidade Federal de Goiás, 2012-02-17) ANDRADE, Sara Rosa de Sousa; VIEIRA, Marcus Fraga; http://lattes.cnpq.br/4153462617460766; AMARAL, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579Introduction: The pregnant woman's body promotes many changes, including their biomechanics. The hormonal action which increases the laxity causes structural changes in the static and dynamic skeleton. Other factors, such as weight gain, growth of the uterus and the breasts, will help changing the gravitational forces of the pregnant woman and cause large static and dynamic postural adjustments in pregnant women. The startup of gait position is the transition from quasi-static to the first step. It is a task that challenges the postural control, because the demands on the neuromuscular system are increased at the beginning of the march, since it is required a complex integration of neural mechanisms, muscle activity and biomechanical forces. Objective: describe the oscillation amplitude and mean velocity of center of pressure during startup of gait, to compare the behavior of the center of pressure between the three groups at different gestational periods, verify that the changes in the behavior of the center of pressure along the pregnancy is at risk dynamic stability for pregnant women. Methods: A total of oscillation amplitude and velocity of displacement of center of pressure during startup of gait in 57 low-risk pregnancies in three trimesters. Results: Significant differences were found when comparing the groups 1º trimester and 3º trimester for the variable amplitude of oscillation mediolateral and mediolateral displacement speed. Discussion: Pregnant women tend to decrease the amplitude of oscillation mediolateral and mediolateral displacement speed during gestation. Conclusions: The amplitude of oscillation anteroposterior and mediolateral displacement speeds and respective of the first quarter from the third there was, on average, a gradual decrease to a platform and to the platform 2. There were significant differences in the oscillation amplitude variables mediolateral and mediolateral displacement speed when comparing the groups 1° trimester and 3° trimester, being higher in 1º trimester for both variables. The variables analyzed showed minor differences and do not constitute an imminent risk to the dynamic stability of the pregnant woman.Item Fatores associados ao comportamento sexual de risco em adolescentes e adultas jovens(Universidade Federal de Goiás, 2018-07-03) Anjos, Caroline Ferreira dos; Alves, Rosane Ribeiro Figueiredo; http://lattes.cnpq.br/8335736301768972; Saddi, Vera Aparecida; Deus, José Miguel de; Conde, Délio MarquesAdolescents and young people engage in risky sexual behavior, resulting in increased number of sexually transmitted infections, and maintaining high rates of pregnancy. PURPOSE. To evaluate the differences in sociodemographic and behavioral characteristics among sexually active and virgin participants; to estimate the prevalence and to identify factors associated with sexual iniciation up to age 15, and inconsistent condom use, and identify the reasons for not using condom among adolescents and young adults. METHODS. A community-based, cross-sectional study involving 1072 adolescents and young women, aged 15 to 24 years, living in three medium-sized cities in the state of Goiás, between 2007 and 2009. All of them answered a questionnaire containing sociodemographic and behavioral data. In order to evaluate the factors associated with sexual iniciation up to age 15, and inconsistent condom use, a logistic regression analysis was performed, with odds ratio (OR) and adjusted OR, with 95% confidence interval and level of statistical significance of 5% (p <0.05). All of them signed the free and informed consent form. For minors under 18 years old the exemption of the parents' signature was obtained by court order. The project was approved by the Ethics and Research Committee. RESULTS. Of 1072, 64.9% were sexually active. Sexually active women were 6.3 (95% CI: 3.98-9.96) times more probability of being older than 19 years old, and 2.04 (95% CI: 1.19-3.49) times more probability of having schooling less than eight years. The prevalence of sexual iniciation up to age 15 was 46.4% (95% CI: 42.7-50.1) and inconsistent condom use was 73.2% (95% CI: 63.9% 82.6). The factors associated with sexual iniciation up to age 15 were age less than 19 years old, had no religion and had schooling less than eight years, with a OR of 3.13 (2.22-4.40), 2.05 (1.17-3.58) and 6.21 (4.14- 9.32) respectively. The only factor associated with inconsistent condom use was marital status or stable union, with OR 4.63 (2.86-7.50). The most frequently cited reasons for non-use of condom were "partner trust" by 49.8% and "partner dislikes" by 43.7%. CONCLUSION. The prevalence of sexual initiation up to age 15, and inconsistent condom use were high. The factors associated with these behaviors were different. Age less than 19 years old were associated with sexualiniciation up to 15, indicating a likely reduction in the age of sexual iniciation in adolescence. The most frequent reasons for not using condoms were related to the sexual partner, which indicates that gender factors need to be addressed in sex education strategies.Item Prevalência da Chlamydia trachomatis pela técnica de reação em cadeia da polimerase (pcr) em mulheres inférteis(Universidade Federal de Goiás, 2012-04-04) Approbato, Fabiana Carmo; Approbato, Mário Silva; http://lattes.cnpq.br/3408700658976397; Approbato, Mário Silva; Amaral, Waldemar Naves do; Ferreira, Rui GilbertoThe Chlamydia trachomatis is a common factor of sexually transmitted diseases. If not treated it can induce tubal obstruction, ectopic pregnancy and infertility. In adolescent women, the prevalence can reach 30%. When look for infertility treatment, the women are at older age, so they are at a different prevalence of Chlamydia. Objectives: To evaluate the prevalence of Chlamydia trachomatis by PCR, enzyme immunoassay or indirect immuno fluorescence at infertile patients. Methods: Design: Prevalence study. Diagnoses Test. Setting: Reproductive Laboratory (LABREP) - HC / UFG and Mater Clinic of Obstetrics and Gynecology, Goiânia, Brazil. Patients: One hundred and twenty patients attended from 2011 to 2012, from 20 to 48 years old. Main Outcome Measures: Age frequency histogram, exposition to pregnancy time, Chlamydia prevalence, Odds ratio for tubal obstruction, ectopic pregnancy and others STDs (Sexually Transmitted Diseases). It was calculate the age histogram frequency, and pregnancy exposition time. We used Chi Square statistical for Odds risk to tubal obstruction for serum positive patients; the Odds risk to ectopic pregnancy for serum positive patients and Odds risk to others STDs for serum positive patients. The rejection p was 5 % (p = 0.05). The Statistical Software used was BioEstat® and excel®. The study was submitted and approved by ethics committee of Clinical Hospital of Federal University of Goias State, Brazil. Results: The patients average age was 33.2 years, above of adolescent age prevalence, when chlamydia is frequently found. The average of exposition to pregnancy was 48.6 months. The PCR Chlamydia detection was less than 1 % (0.83 %). The Chlamydia PCR prevalence for serum positive was 2.4 % (one patient). We did not found Positive PCR between serum negative patients. The Odds to tubal obstruction for serum positive patients was 2.5. This was statistically significant. The Odds Ratio to ectopic pregnancy for serum positive patients was 1.31. This was not statistically significant. The Odds Ratio to others STDs for serum positive patients was 4.1 (p = 0.024). The Odds Ratio to ectopic pregnancy for tubal obstruction was 19.1. This was highly significant (p = 0.001). The NNT was 42. Conclusions: We conclude that C. trachomatis has a very low frequency at this population ( < 1 %), but heavy sequels of infection stays. The average age of the infertile patients was 33.2 years, above of the age mean of adolescents. We found association of positive serology screening and statistically significant risk for tubal obstruction, ectopic pregnancy and to others STDs.Item Impacto da atenção farmacêutica na qualidade de vida e no perfil clínico de pacientes com hipertensão arterial assistidos pela estratégia saúde de família(Universidade Federal de Goiás, 2013-10-11) Aquino, Aline Teixeira de; Lima, Dione Marçal; http://lattes.cnpq.br/4310011929664114; Amaral, Rita Goreti; http://lattes.cnpq.br/3665611660713029; Amaral, Rita Goreti; Garrote, Clévia Ferreira Duarte; Zampieri , Ana Lúcia Teixeira de CarvalhoIntroduction: Pharmaceutical care is a practice model that allows direct interaction between the pharmacist and the patient and the healthcare team. This practice uses the pharmacotherapeutic follow-up as a tool in the identification and resolution of Drug Related Problems, which can contribute to rational drug use and collaborate with achieving positive clinical outcomes that minimize the physical and psychosocial impact that chronic diseases and their treatment can promote the quality of life of patients. Objective: The aim of this study was to evaluate the impact of pharmaceutical care on quality of life and on clinical profile of patients with hypertension, assisted by the Family Health Strategy. Methods: Was conducted a longitudinal intervention study involving 29 patients with hypertension who were assisted by the Family Health Strategy of two Basic Health Units at the sanitary district north in the city of Goiânia - GO. They received pharmacotherapeutic follow-up for 12 months, through systematized, pre-schedule and documented home visits. Were included patients that had at least two of the following inclusion criteria: blood pressure greater than or equal to 140x90 mm Hg, using three or more drugs, change in the therapeutic regimen two or more times in the last year , presence of co-morbidities, and history of non-adherence to antihypertensive therapy. Data collection was performed using follow-up pharmacotherapeutic reports, visits reports and form registration of clinical and laboratory parameters, “Mini Cuestionario de Calidad de Vida en Hipertensión Arterial” (Minichal) and Morisky-Green-Levine Questionnaire. The variables studied were the socio economic and demographic profile, clinical profile, lifestyle, Drug Related Problems, adherence to antihypertensive therapy and quality of life. For descriptive statistics were used mean, standard deviation and measures of absolute and relative frequency. For statistical tests were used the McNemar parametric test, odds ratio, and linear mixed models, generalized mixed models, linear mixed models. The threshold for statistical significance set at p <0.05, with a confidence interval of 95%.Results: The results showed that there was a reduction in the number of drug-related problem of security, increased self-reported adherence to antihypertensive treatment. There was improvement in quality of life related to the somatic manifestations domain and its correlation with the reduction in the number of drug-related problem of security. There was a significant reduction in abdominal circumference of female patients, there were found correlation between the quality of life for the somatic manifestations domain and the clinical outcomes of diastolic blood pressure, triglycerides and abdominal circumference. Just the diastolic blood pressure showed correlated with mental state domain of quality of life. There was a positive correlation between interventions directed to the patient related with the medications domain and the changes in the clinical results for fasting glucose. The life style domain presented correlation with systolic and diastolic blood pressure. Conclusions: The results showed that the pharmaceutical care reduced the number of security Drug Related Problems, improved quality of life related to the somatic manifestations domain. There was an increase in adherence to antihypertensive treatment declared by patients; however this did not influence the improvement of quality of life. Furthermore, the results revealed that there was a significant reduction in the women's measures abdominal circumference; that the pharmaceutical interventions directed to the patient influenced in the clinical results of fasting glucose, systolic and diastolic blood pressure; and that the changes observed in the clinical outcomes of diastolic blood pressure, triglycerides and abdominal circumference impacted on the quality of life related to the somatic manifestations.