Biomarcadores no diagnóstico da doença renal em cães
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2017-03-06
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Universidade Federal de Goiás
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The goal of the study was to evaluate cystatin C and other biomarkers as diagnostic
tools in canine renal disease. The project was divided in two studies. In the first study
renal injury was induced in 6 animals by subcutaneous administration of gentamicin
(30mg/kg) for 10 days, and 6 animals were kept as controls. Animals were evaluated
for 45 days by the following clinical and laboratorial parameters: physical
examination; hemogram and fibrinogen levels; measurement of creatinine, urea,
total proteins, albumin, phosphorus, calcium, sodium, potassium, cholesterol levels
(biochemical analysis); serum protein electrophoresis; urine sodium, potassium,
gamma glutamyl transferase and alkaline phosphatase levels; urinalysis; urine
protein / creatinine ratio; hemogasometry and non-invasive systemic arterial
pressure. The second study evaluated the level of cystatin C in 58 dogs suffering from
different stages (2-4) of chronical renal disease, as defined by International Renal
Interest Society (IRIS) guidelines. Six animals presenting acute renal injury induced bygentamicin treatment were also evaluated (for 20 time points upon injury). The
results indicated that changes in urine gamma glutamyl transferase and fractional
excretion of sodium and potassium were the earliest parameters indicating acute
renal injury, even when compared to most common renal disease biomarkers: urea
and creatinine. Cystatin C measurement, on the other hand, showed little value for
early detection of chronic kidney disease and acute kidney injury in dogs.
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SOUZA, S. N. Biomarcadores no diagnóstico da doença renal em cães. 2017. 117 f. Tese (Doutorado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2017.