Prevalência e Espectro de Fenótipos Cognitivos na Esclerose Múltipla e Fatores de Risco Relacionados

Abstract

: Cognitive impairment (CI) is recognized as a prevalent and disabling symptom in Multiple Sclerosis (MS), compromising activities of daily living (ADLs), employability, social life and adherence to treatment, sometimes more intensely than physical limitations themselves. Objectives: This study aimed is describe the spectrum and prevalence of CI phenotypes in MS in patients from a referral center in the city of Goiânia, potential risk factors and how they may be related to the evolution of the disease. Methods: A sample of 117 people with MS (PwMS) from a university reference center was selected, diagnosed according to McDonald’s revised criteria and evaluated cognitively, psychologically and functionally with the following instruments: Brief Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis (BRB-N), Beck Depression Inventory- 2ª edition (BDI-II), Beck Anxiety Inventory (BAI) and Expanded Disability Status Scale (EDSS). Results: We found CI in 60.7% of the sample, with 25.6% classified as mild and 35.1% severe, of which 17.1% met criteria for dementia. Conclusions: MS generates mild cognitive impairment (MCI) in patients and can increase the possibility of dementia with MS dementia being specific and associated with the motor severity of the disease.