Relação entre a presença de macrófagos no microambiente tumoral e fatores prognósticos em câncer de mama
Nenhuma Miniatura disponível
Data
2018-04-26
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
Introduction: The analysis of possible biomarkers associated with the more aggressive behavior
of breast carcinomas, linked to clinical and prognostic information, can provide important data in
the treatment of patients with breast cancer. There are indications that the presence of tumor
associated macrophages (TAMs) in the tumor microenvironment is associated with a worse
prognosis for women with breast cancer. Objective: To evaluate the importance of the presence of
macrophages in the tumor microenvironment in breast neoplasms. Methods: This retrospective
cross-sectional study included 93 cases of women with invasive ductal breast cancer and submitted
to immunohistochemical analysis of the markers for CD68 (M1 / M2) and CD163 (M2)
macrophages. The counts of CD68 + and CD163 + cells were performed in a peritumoral region,
considering hot spot fields, and the cases under study were classified as low infiltration or high
infiltration using semiquantitative evaluation of cell marking. Statistical analysis was performed
using the Stata 13.0 program (Stata Corp., College Station, TX, United States), with bivariate
analysis, considering the level of significance of p <0.05, and multivariate analysis where the
variables with p <0.2 were submitted to the logistic regression test. The Kaplan-Meier method and
the log-rank test were used in the analysis of survival curves. Results: High levels of TAMs
(CD68 +) were significantly correlated with: patient age, presence of distant metastasis, more
advanced tumor staging, absence of estrogen receptors (ER) and progesterone (PR), and triple
negative breast cancer (TN). The reduction of the overall survival rate in the cases of women with
breast cancer studied was significantly associated with high infiltration of TAMs (CD68 +). The
high infiltration of TAMs phenotype M2 (CD163 +) was significantly correlated with the
independent variables presence of distant metastasis, absence of RE and TN breast cancer.
Conclusions: The association of the analysis of TAM biomarkers with clinical and prognostic
information showed that the high presence of macrophagic infiltrate has a significant prognostic
value, adding information on the relationship between the presence of macrophages in the tumor
microenvironment of cases of women with carcinoma and the clinical-pathological characteristics
of the tumor. In addition, TAMs appear as potential prognostic markers for breast cancer.
Descrição
Palavras-chave
Citação
LABRE, Luciana Vieira Queiroz. Relação entre a presença de macrófagos no microambiente tumoral e fatores prognósticos em câncer de mama. 2018. 121 f. Tese (Doutorado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2018.