Fatores relacionados aos níveis de retinol sérico em crianças de seis a 24 meses de creches municipais de Goiânia-Goiás
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2013-05-16
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Universidade Federal de Goiás
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Introduction: Vitamin A deficiency can increase susceptibility to infection and reduce
growth rate, besides it is an important cause of blindness in childhood. Infants and
preschools are the most vulnerable groups to this deficiency. Objective: To evaluate
the factors related to serum retinol in infants aged from six to 24 months who were
attended at municipal daycare centers (CMEIs) in the city of Goiânia - Goiás State,
Brasil. Methods: A cross-sectional study, undertaken between 2005 and 2006 in
CMEIs located in Goiânia. A socioeconomic and demographic survey was performed
as well as blood samples were drawn from 193 infants to analysis of complete blood
count (CBC), serum retinol, ferritin and C-reactive protein (CRP). Retinol was
determined by High Performance Liquid Chromatography (HPLC) being considered
deficient retinol levels under 0,7 μmol/L. Data were analyzed by the softwares
Stata/SE 12.0 and Statistical Package for the Social Sciences 18.0 (SPSS). T
student test, Pearson’s or Spearman’s correlation and multiple linear regression were
performed. Results: The mean serum of retinol level was of 1,00 ± 0,38 μmol/L and
the prevalence of vitamin A deficiency was of 21,8%. The average levels of retinol did
not differ significantly between gender, age, type of water consumed, prenatal
assistance, breastfeeding (predominant or current), presence or absence of anemia
and ferritin levels. There was no correlation between the mother’s schooling, birth
weight and number of infants younger than five years of age with serum retinol.
There was association between vitamin A deficiency and inflammation (p=0,04). For
each CRP unit that increased there was a reduction of 0,133 e 0,115 mg/dL in serum
retinol levels, according to two models of multiple linear regression, keeping other
variables constant. Conclusion: Vitamin A deficiency in infants who were attended at
a municipal daycare centers in Goiânia is high and the factor related to this deficiency
was the inflammatory state of the child which is represented by the CRP serum
levels, adjusted by sanitary sewage, habitation location and ferritin level.
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LOBO, Lina Monteiro de Castro. Fatores relacionados aos níveis de retinol sérico em crianças de seis a 24 meses de creches municipais de Goiânia-Goiás. 2013. 97 f. Dissertação (Mestrado em Nutrição e Saúde) - Universidade Federal de Goiás, Goiânia, 2013.