ICB - Trabalhos de Conclusão de Curso
URI Permanente para esta coleção
Navegar
Navegando ICB - Trabalhos de Conclusão de Curso por curso "Biomedicina (RMG)"
Agora exibindo 1 - 3 de 3
Resultados por página
Opções de Ordenação
Item Detecção de vírus parainfluenza em amostras respiratórias de indivíduos com sintomas respiratórios no município de Goiânia-GO(Universidade Federal de Goiás, 2024-08-06) Galan, Izabela Leite; Souza, Menira Borges de Lima Dias e; Souza, Menira Borges de Lima Dias e; Franco, Fernanda Craveiro; Cardoso, Juliana Lamaro; Carneiro, Megmar Aparecida dos SantosUpper and lower respiratory tract infections can be caused by a variety of viruses, including human parainfluenza viruses (HPIV). These pathogens are significantly associated with these syndromes in both paediatric and adult patients, presenting clinically in milder forms with cold-like symptoms such as rhinorrhea, cough and sore throat, and in more severe forms that can lead to death. In this context, HPIV was detected by real-time RT-PCR in 217 nasopharyngeal swabs from patients with respiratory symptoms who were treated in outpatient and emergency units in Goiânia-GO between September 2023 and January 2024. The study population was predominantly female and aged between 18 and 44 years. HPIV was detected in 2.89% (6/207) of the samples considered valid for analysis between November and December. The main age groups among positive cases were children aged 5-14 years, adolescents aged 15-17 years, adults aged 45-64 years and elderly patients aged 65 years and older. The most common respiratory signs and symptoms were fever, chills, cough, sore throat, headache and body aches. The study provided data on the circulation of HPIV in the municipality, which can support better monitoring and planning of public policies for the control and prevention of respiratory viruses.Item O impacto da epilepsia no processo de aprendizagem e no desenvolvimento acadêmico: uma revisão de literatura(Universidade Federal de Goias, 2024-08-02) Lins, Anne Karolinne Vaz; Pansani, Aline Priscila; Pansani, Aline Priscila; Colugnati, Diego Basile; Lima Junior, Claudio Quintino deEpilepsy is a neurological disease, characterized by the brain's predisposition to generateepileptic seizures, through an imbalance between excitatory and inhibitory activity, resultingfrom excessive, hypersynchronous and abnormal neuronal discharges. Epileptic seizures canbe classified according to their etiology and place of onset into focal, generalized and onset ofunknown. Epilepsy can be accompanied by psychiatric comorbidities, such as depression,anxiety, attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder, suchcomorbidities can significantly affect the learning process of people with epilepsy, as well asadverse effects of anti-seizure medications. Therefore, the objective of this work is to exposethe impact of epilepsy on the learning process and academic development. Throughout thisreview it is possible to observe the consequences of epilepsy and its comorbidities on learningand socialization, as well as the long-term effects related to difficulties in the schoolenvironment.Item Padronização de PCR multiplex para as regiões hexon penton e fibra de adenovírus humano(Universidade Federal de Goias, 2024-08-02) Sebata, Mayumi Ribeiro; Souza, Menira Borges de Lima Dias e; Souza, Menira Borges de Lima Dias e; Carneiro, Megmar Aparecida dos Santos; Freitas, Erika Regina Leal de; Porto, Pedro SoaresHuman adenoviruses (HAdV) are members of the Adenoviridae family classified withinthe genus Mastadenovirus. Within this genus, there are seven species of adenovirusesidentified from A to G, comprising over 100 known genotypes. Adenoviruses arenon-enveloped viruses with an icosahedral capsid primarily composed of hexon, penton,and fiber proteins. HAdV can cause respiratory, gastrointestinal, and ocular infections,manifesting symptoms such as fever, vomiting, and diarrhea, varying in severity basedon the host's immune system. Multiplex Polymerase Chain Reaction (PCR) utilizesmultiple primer pairs in a single reaction, noted for its efficiency and cost-effectiveness.Thus, multiplex PCR represents an effective alternative for enhancing research andlaboratory diagnosis of adenovirus infections. This study aims to standardize andvalidate a multiplex PCR assay for detecting hexon, penton, and fiber regions of humanadenoviruses across various sample types. Primer pairs were designed to target thesegenome regions in control samples of adenovirus species 2 cultured in A-549 cells andin samples from patients who underwent allogeneic hematopoietic progenitor celltransplantation and were previously positive for HAdV. Standardization of the multiplexPCR assay for penton and fiber genes was successful; however, amplifying the hexongene proved more challenging. The data obtained in this study will serve as a tool forfuture investigations into adenovirus recombination regions and deeper genomicanalyses of adenoviruses.Versão GRT_BC_maio