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Item Plataformas de microagulhas para liberação transdérmica de fármacos: uma revisão de literatura(Universidade Federal de Goiás, 2023-02-10) Lima, Giovanna Almeida; Costa, Hemerson da Silva; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Fontanezi, Bianca Bueno; Cardoso, GleidsonThe skin is an attractive option for the delivery of therapeutic agents such as vaccines, biomolecules, and small molecules. However, the superficial layer of the skin, the stratum corneum, can limit the bioavailability of the pharmaceutical active. Drug penetration through the skin is limited to potent molecules with low molecular weight and moderate fat solubility. The efficacy of a drug depends not only on the properties of the active component, but also on the underlying mechanism of delivery to the body. From this perspective, it is important to consider the optimal method of drug delivery according to the drug's properties. The use of micro-needling enables minimally invasive and highly safe delivery. Microneedling, a transdermal drug delivery system, is growing rapidly due to its advantages in improving patient access to drugs, replacing other routes of administration. The purpose of this literature review was to present microdevices as a means of drug administration through microneedles, as well as the technical characteristics and limitations.