Prevalência de talassemias e hemoglobinas variantes em pacientes portadores de lúpus eritematoso sistêmico
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Data
2008
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Resumo
Systemic lupus erythematosus (SLE) is a typically multigenic and
multifatorial disease with remarkable clinical and pathogenic
complexities. The causes of SLE are not totally known, but It is
known that environmental and genetic factors are involved. Among
various clinical manifestations observed in lupus patients, anemia
calls the attention because of a prevalence of 52.5% of the patients
with RBC indices suggestive of anemia identified in this study.
Although anemia is usually seen in patients with SLE, studies of the
prevalence of hereditary anemias, particularly hemoglobinopathies,
have not been carried out in populations. The objective of this work
was to evaluate the prevalence of hemoglobinophaties in patients
with SLE. We studied 80 blood samples of patients with SLE in
Hospital das Clínicas in Goiania, Brazil. The frequency of alterations
of the hemoglobin was 10.0% (8 patients). Among these alterations,
the most prevalent was alpha thalassemia in 4 patients (5.0% of the
studied population). The heterozygosity for hemoglobin S was seen
in 2 patients (2.5%), hemoglobin C in one patient (1.25%) and one patient was identified with beta thalassemia minor. No homozygous
cases were found in the present study. According to this work no
difference in the prevalence of hemoglobin disorders was observed
between general population and patients with SLE. Rev. bras.
hematol. hemoter. 2008;30(1):24-28.
Descrição
Palavras-chave
Talassemia, HPLC, Hemoglobinas variantes, Lúpus eritematoso sistêmico, Diagnóstico laboratorial, Thalassemia, Variant hemoglobins, HPLC, Systemic lupus erythematosus, Laboratorial diagnoses
Citação
CASTRO, Frank S. et al.Prevalencia de talassemia e hemoglobinas variantes em pacientes portadores de lupus erimatoso sistemico. Revista Brasileira de Hematologia e Hemoterapia, São José do Rio Preto, v. 30, n. 1, p. 32-37, jan./fev. 2008.