Influência da hereditariedade em marcadores de risco para hipertensão arterial
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Data
2015
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Resumo
Background: Genetic and environmental factors are equally
important in determining blood pressure (BP). Changes in BP,
insulin resistance (IR) and echocardiograms have been studied
in offspring of hypertensive parents with contradictory results.
Objective: Studying IR, BP, exercise test, cardiac morphology
and function with echocardiogram, in normotensive young, with
and without family history (FH) of hypertension (HTN). Methods:
Students, 18 to 30 years, were included. They were divided into
3 groups: neither parent with HTN – G1, one of parents with
HTN – G2 and both parents with HTN – G3. Exclusion criteria –
HTN, obesity, smoking, using medication and comorbidities.
The study evaluated weight, height, Body Mass Index (BMI),
office BP, Ambulatory Blood Pressure Measurement (ABPM),
exercise test, glycemia, insulin, HOMA-IR and Echocardiogram.
ANOVA test was used to compare groups. Partial correlation
adjusted for sex was used to evaluate associations. Results:
Sixty-three individuals were studied. They were divided into 3
groups: G1 (n=21), G2 (n=22) and G3 (n=20). Mean age was
21.1±2.2 years, 39.1% were males. There was no difference
regarding age, weight, height, BMI, office BP and ABPM. Group
3 had the lowest dipping of systolic BP (SBP) (p=0.052), the
highest insulin levels (p=0.019), HOMA (0.006) and left atrium
diameter (LAD) (p=0.020). We found a positive correlation
between LAD with SBP (p=0.005), serum insulin (p=0.003)
and HOMA (p=0.003). Conclusion: Results indicate that
young offspring of hypertensive parents had more IR, changes
in the BP circadian rhythm and have a bigger LAD, even with
normal BP values.
Descrição
Palavras-chave
Hipertensão, Hereditariedade, Fatores de risco, Hypertension, Heredity, Risk factors
Citação
JARDIM, Tiago de Souza Veiga et al. Influência da hereditariedade em marcadores de risco para hipertensão arterial. Revista Brasileira de Hipertensão, Rio de Janeiro, v. 22, n. 2, p. 65-71, 2015.