FM - Artigos publicados em periódicos

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Navegando FM - Artigos publicados em periódicos por Autor "Alencar, Rita de Cássia Gonçalves de"

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    Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma
    (2010) Watanabe, Satiro; Watanabe, Rogério Haruo; Leite, Angélica Ferreira Oton; Alencar, Rita de Cássia Gonçalves de; Oliveira, José Carlos de; Leles, Cláudio Rodrigues; Batista, Aline Carvalho; Mendonca, Elismauro Francisco de
    Cell proliferation markers play an important role in the biological behavior of neoplasms. This study investigated the immunohistochemical expression of PCNA, Ki-67 and Cyclin B1 proteins based on the pattern of cell invasion in oral squamous cell carcinoma (OSCC). A total of 39 OSCC specimens and 13 samples of normal oral mucosa (control) were immunohistochemically analyzed. Protein expression was evaluated according to World Health Organization – Histological Malignancy Grading (WHO-HMG) and a specific grading system for invasion, graded from 1 to 4, varying from a consistently well-defined “pushing” border to diffuse infiltration and cellular dissociation, and was then correlated with clinical features. We found higher expression of Ki-67 and Cyclin B1 in OSCC when compared with the control group. High Ki-67 expression levels were more commonly seen in the floor of the mouth than in the tongue (P = 0.009). Cyclin B1 showed a positive correlation with histological grade, according to WHO-HMG criteria (P = 0.01). Our results suggest that Cyclin B1 is a reliable proliferation marker for indicating degree of tumor proliferation. Correlations between PCNA, Ki-67, Cyclin B1 and invasive tumor front with overall survival were not observed. Further studies are needed in order to elucidate whether cell proliferation activity at the tumor invasion front is related to prognosis. (J Oral Sci 52, 417-424, 2010)
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    Atypical esthesioneuroblastoma invading oral cavity: a case report and review of the literature
    (2014-01) Zeidler, Sandra Lúcia Ventorin von; Guidi, Rafaela; Alencar, Rita de Cássia Gonçalves de; Ribeiro, Renato de Aguiar; Mendonca, Elismauro Francisco de; Batista, Aline Carvalho; Ribeiro-Rotta, Rejane Faria
    Esthesioneuroblastoma is an uncommon tumour of neuroectodermal origin. The authors describe a rare presentation of an atypical esthesioneuroblastoma invading oral cavity. The clinical presentation, aetiology, diagnosis, and management of this condition are discussed. The patient developed significant swelling in the right anterosuperior alveolar mucosa and had moderate tooth mobility. Conventional x-rays and computed tomography revealed a large osteolytic lesion, with imprecise limits. Histological findings along with immunohistochemical staining results and clinical features led to the diagnosis of high-grade esthesioneuroblastoma. Local recurrences and neck metastasis were detected. The rare oral findings produced delayed in diagnosis which may lead to a compromise in planning and execution of further radical management and thus a poor prognosis.
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    Carcinoma espinocelular da mama: relato de caso
    (1999) Pereira, Rubens José; Pereira, Wilson Garcia; Ribeiro, Luiz Fernando Jubé; Alencar, Rita de Cássia Gonçalves de; Saddi, Vera Aparecida; Queiroz, Geraldo Silva; Freitas Júnior, Ruffo de
    Squamous cell carcinoma of the mammary tissue is a very rare neoplasm, representing less than 1% of all breast carcinomas. The present study reports a case of squamous cell carcinoma of the breast, treated at the Hospital Araújo Jorge/ACCG. The tumor diagnosis, treatment and prognosis are also discussed.