Doutorado em Nutrição e Saúde
URI Permanente para esta coleçãohttp://200.137.215.59/tede/handle/tede/9163
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Item type: Item , Fortificação da alimentação infantil com micronutrientes em pó: uma estratégia para prevenção da deficiência da vitamina E(Universidade Federal de Goiás, 2025-06-23) Oliveira, Marina Tissot de; Hadler , Maria Claret Costa Monteiro; http://lattes.cnpq.br/6754793957094104; Hadler, Maria Claret Costa Monteiro; http://lattes.cnpq.br/6754793957094104; Ongaratto, Lana Angélica Braudes Silva; http://lattes.cnpq.br/7462533224738626; Mortoza, Andréa Sugai; http://lattes.cnpq.br/4896920176590532; Vilela, Ana Amélia Freitas; http://lattes.cnpq.br/1448314956692749; Guimarães, Marília Mendonça; http://lattes.cnpq.br/4789197779301037Embargada.Item type: Item , Consumo de alimentos ultraprocessados e o declínio da função renal em indivíduos com doença renal crônica não dialítica(Universidade Federal de Goiás, 2025-08-22) Sousa, Amanda Goulart de Oliveira; Costa, Nara Aline; http://lattes.cnpq.br/2329606765557184; Souza , Luciana Bronzi de; http://lattes.cnpq.br/1883145075643997; Peixoto, Maria do Rosário Gondim; http://lattes.cnpq.br/6813295858384008; Peixoto, Maria do Rosário Gondim; Nerbass, Fabiana Baggio; Vogt, Bábara Perez; Freitas, Ana Tereza Vaz de Souza; Feresin, Rafaela GonçalvesItem type: Item , Análise físico-química, composição Bioativa e aplicações tecnológicas da polpa de juçara(Universidade Federal de Goiás, 2025-01-23) Siqueira , Ana Paula Silva; Pimentel, Gustavo Duarte; http://lattes.cnpq.br/2291502930022342; Pimentel, Gustavo Duarte; http://lattes.cnpq.br/2291502930022342; Daleprane, Júlio Beltrame; http://lattes.cnpq.br/6027048461430935; Souza, Patrícia Amaral; http://lattes.cnpq.br/2108602143480173; Baptista, Sheyla de Liz; http://lattes.cnpq.br/3514635451892721; Schulz, Mayara; http://lattes.cnpq.br/7137835674319279EmbargadaItem type: Item , Consumo de alimentos ultraprocessados em adultos: Vigitel Goiás(Universidade Federal de Goiás, 2025-02-28) Silva, Jacqueline Aparecida Assis; Silva, Lara Lívia Santos da; http://lattes.cnpq.br/3374527511007494; Peixoto, Maria do Rosário Gondim; http://lattes.cnpq.br/6813295858384008; Peixoto, Maria do Rosário Gondim; Farias Júnior, Gilvo de; Miranda, Renata Costa de; Guimarães, Marília Mendonça; Silva, Simoni Urbano daEmbargadoItem type: Item , Prevalência de obesidade eutrófica e consumo de alimentos ultraprocessados de adultos(Universidade Federal de Goiás, 2025-01-23) Santos, Acsa de Castro; Cominetti, Cristiane; http://lattes.cnpq.br/3143023553465749; Cominetti, Cristiane; Oliveira, Klébya Hellen Dantas de; Cunha, Marcela de Sá Barreto da; Peixoto, Maria do Rosário Gondim; Guimarães, Marília MendonçaThe aim of this study was to investigate the evolution of the prevalence of normal weight obesity, as well as the trend in the consumption of ultra-processed foods in two distinct samples. Samples of individuals from the biennia (2001–2004 and 2011–2018) of the National Health and Nutrition Examination Survey (NHANES) and a convenience sample from a national academic community were evaluated. Individuals aged 20 to 59 years and with a body mass index classified as normal weight were eligible for assessment regarding body composition and consumption of ultra-processed foods. Student's t-test or Mann-Whitney test were used to compare means, and Pearson's chi-square test or Fisher's exact test were applied to compare prevalence. Linear and logistic regression models were developed to assess the associations between the variables. The results showed no trend of significant increase in the prevalence of normal-weight obesity over the analyzed biennia and that the mean body fat percentages were also similar. Likewise, the consumption of ultra-processed foods did not show an increasing trend over the years. However, in all biennia it was observed more than 50% of individuals with a high percentage of body fat, despite the normal body mass index. The 2013–2014 biennium stands out, with a prevalence of normal weight obesity close to 75%. In the national convenience sample, individuals with normal-weight obesity had a higher energy intake from processed meats compared to those with normal body fat percentages. Consumption of energy and added sugar was associated with the presence of normal-weight obesity. Therefore, it is possible to conclude that the NHANES sample showed a high prevalence of normal-weight obesity, but the consumption of ultra-processed foods did not increase in all biennia. In the national sample, there were no differences in the consumption of ultra-processed foods between individuals with normal-weigh obesity or adequate body fat percentages. However, the results highlight the importance of identifying this condition early, in order to minimize risks associated with a high percentage of body fat in the medium and long terms.Item type: Item , Alimentação, metilação e expressão do microRNA-375, e prognóstico em carcinoma espinocelular de cabeça e pescoço(Universidade Federal de Goiás, 2025-01-15) Lima, Ana Carolina da Silva; Horst, Maria Aderuza; http://lattes.cnpq.br/4145824009736834; Horst , Maria Aderuza; Martucci , Renata Brum; Heidor, Renato; Murad, Leonardo Borges; Costa, Nara AlineThe objective of this study was to identify whether the methylation pattern of MIR375 and the expression of miR-375 are associated with diet and prognostics factors in patients with head and neck squamous cell carcinoma (HNSCC). This study was conducted in two stages. The first stage was a cross-sectional study that included individuals of both sexes, aged between 20 and 80 years, who were newly diagnosed and in the pre-treatment phase of HNSCC. Sociodemographic, anthropometric, lifestyle, and clinical data were collected, including tumor staging, cellular differentiation, and biochemical tests. Dietary intake was assessed using a food frequency questionnaire. Dietary patterns were determined through principal component analysis. Additionally, dietary intake was evaluated according to the degree of food processing using the NOVA classification. The second stage consisted of a bioinformatics study based on data from The Cancer Genome Atlas (TCGA). This stage aimed to assess the prognostic value of the methylation pattern in the gene regions of MIR375 and subsequently select promoter regions for further study. The association between dietary patterns and clinical data was evaluated using multinomial logistic regression. The association between diet, as classified by NOVA, and inflammatory markers was assessed using multiple linear regression. The prognostic value of the molecular results from the bioinformatics analysis was evaluated using Kaplan-Meier survival curves for overall and disease-free survival and Cox regression. Regarding the results, three dietary patterns were identified: "healthy," "processed," and "mixed." The "processed" dietary pattern was associated with stage III (OR: 2.47; 95% CI: 1.43–4.26; p = 0.001) and stage IV (OR: 1.78; 95% CI: 1.12–2.84; p = 0.015) of HNSCC. No association was found between dietary patterns and cellular differentiation (p > 0.05). Regarding the NOVA classification, the processed food group was positively associated with the systemic immune-inflammation index (β: 1.95 x 10³; p = 0.045) and the neutrophil-to-lymphocyte ratio (β: 5.93 x 10³; p = 0.003). In relation to the bioinformatics study, hypermethylation of the N shore region of MIR375 was an unfavorable predictor for overall survival (RR: 1.63; 95% CI: 1.11–2.40; p = 0.014) and disease-free survival (RR: 1.80; 95% CI: 1.13–2.88; p = 0.013). Thus, greater adherence to a dietary pattern composed of processed foods was associated with more advanced stages of HNSCC and inflammatory markers. DNA methylation in regions that may influence miR-375 expression can be considered a predictor of survival in HNSCC, particularly in the N Shore region. This study presents relevant preliminary results on the relationship between diet, epigenetic mechanisms, and prognosis in HNSCC, guiding future studies that may complement the main investigation and deepen the conclusions found.Item type: Item , Potencial prebiótico da polpa de baru(Universidade Federal de Goiás, 2022-08-29) Santos, Aline Medeiros Alves; Naves, Maria Margareth Veloso; http://lattes.cnpq.br/6563181057140270; Naves, Maria Margareth Veloso; Andrade, Roberta Melquiades Silva de; Egea, Mariana Buranelo; Batista, Ângela Giovana; Mendonça, SimoneBaru (Dipteryx alata Vog.) is a fruit native to the Cerrado biome consisting of a thin peel, a fibrous pulp and a woody endocarp, which covers the nut. During the processing of the fruit for nut extraction, the baru pulp is not used by the agro-industry, and its chemical composition and health effects are poorly known. Some studies indicate that baru pulp has dietary fiber and polyphenols, which have prebiotic activity. The growing interest in health and well-being promoting foods from alternative sources, such as agro-industrial by-products, and the social, economic and environmental impacts generated by the use of these by-products justify the search for new prebiotics. Thus, the aims of this study were: to elaborate and publish a systematic review on the prebiotic effect of polyphenols; to carry out and publish a critical review of the literature on the nutritional and functional characteristics of baru; in addition to evaluate the chemical composition of baru pulp and to investigate its effects on the growth and metabolism of probiotics, and on the human colonic microbiota. According to the systematic review, there is strong evidence from preclinical studies that some polyphenols can stimulate the growth of beneficial gut bacteria and increase the production of short-chain fatty acids. The critical review on baru showed the nutritional and functional potential of baru pulp, as well as the gaps in the literature on its chemical composition. Results of the empirical research show that baru pulp has a high content of insoluble fibers and phenolic compounds, mainly hesperidin. Baru pulp stimulated the growth and metabolism of Bifidobacterium animalis subsp. lactis BB-12, Lactobacillus acidophilus LA-05 and Lacticaseibacillus casei L-26. Furthermore, significant beneficial changes were induced by the digested baru pulp on colonic microbiota, with an increase in the abundance of Lactobacillus-Enterococcus, Bifidobacterium and Bacteroides-Prevotella, and the production of lactate and short-chain fatty acids, and pH reduction. Therefore, baru pulp has potential prebiotic properties to be confirmed in preclinical and clinical studies, and to be explored as an ingredient in the formulation of new health-promoting foods.