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Adesão primária ao tratamento farmacológico em pacientes psiquiátricos utilizando a metodologia da proporção dos dias cobertos
(Universidade Federal de Goiás, 2019-12-11) Macedo, Dayane Borges; Queiroz, Thays da Fonseca; Provin, Mércia Pandolfo; Provin, Mércia Pandolfo; Carvalho, Núbia Cristina Burgo Godói de; Silva, Paula Beatriz Medrado e
Treatment adherence is not only related to medication prescription follow-up, it in volves several factors, such as the health system, the patient and the disease itself. Polypharmacological treatment has a great complexity that is increased in patients undergoing psychiatric treatment, in which the use of various drugs are part of the therapy. Objective: To identify the degree of adherence and non-adherence to therapy in these patients, through the methodology of the proportion of days covered. Methods: A cross-sectional and descriptive study was conducted at the Centro de Atenção Psicossocial (CAPS) Novo Mundo in the metropolitan region of Goiânia. The data were obtained from the universal system of the city of Goiânia. The methodology was divided into three stages: (i) data collection; (ii) calculation of the proportion of days covered; (iii) classification of the therapeutic complexity index. Data were collected between May and October to calculate the proportion of days covered. Results: Among 28 selected patients, 18 were female and 10 male, with a mean age of 49 years and a low level of education. Regarding the proportion of days covered, about 60% were adherent, with low therapeutic complexity. Discussion: Female patients were more prevalent in the study, since the prevalence of Mental Disorders in this population is higher. Sociodemographic characteristics may directly affect the degree of adherence. High therapeutic complexity is related to nonadherence to pharmacological treatment. Conclusion: Through the study, it was possible to identify the degree of primary adherence in psychiatric patients and to describe the sociodemographic profile of this population.
Alternativas ao Carbopol 940 na fabricação de álcool em gel
(Universidade Federal de Goiás, 2021-01-15) Cruz, Camila Vieira Milo Bela; Diniz, Danielle Guimarães Almeida; Diniz, Danielle Guimarães Almeida; Ribeiro, Bárbara Cristina Campos; Lemes, Érick de Oliveira
At the end of 2019, a new epidemic of global proportions, motivated by a virus called SARS-CoV-2, (COVID-19), originating in China, forced countless countries to mo-bilize to face the health implications of the infection and in the economy. Hygiene through constant hand washing in an appropriate manner, using water and soap and in the absence of alcohol-based disinfectants, was the main recommendation of the World Health Organization. In view of the great demand for such disinfectants based on of al-cohol, there was a shortage of assets used to produce it worldwide, so this study aimed to develop alcohol gel formulations with different thickener alternatives in order to meet the high demand for this product. The methodology used was the development of 12 al-ternative formulations, where the compatibility between the different gelling agents with the reference thickener was verified. Organoleptic tests (appearance, color and odor), physical-chemical tests (pH, viscosity and alcohol content) and sensory analysis of sti-ckiness were performed after subjecting the samples to extreme temperature conditions and centrifugation tests, aiming at predicting possible instabilities. It was concluded that the best alternative to replace Carbopol, a polymer known commercially and most used to manufacture alcohol in gel, was Luviset 360, a thickener created by Badische Anilin & Soda Fabrik-BASF
Analisar o empoderamento do paciente frente a sua segurança referente ao tratamento farmacológico durante internação
(Universidade Federal de Goiás, 2020-11-18) Neves, Esther Rodrigues; Provin, Mércia Pandolfo; Provin, Mércia Pandolfo; Macedo, Stefane Arruda; Torres, Thais dos Santos Ferreira
Patient safety has been a focus of discussion in recent years, especially the safe use of medication in health institutions. Medication errors are among the most frequent preventable adverse events in hospitalized patients, requiring attention from health professionals and empowerment of those affected by them. An effective measure, considering the patient as the last barrier in preventing errors in the medication system, is to make him an active and empowered member to participate in the decisions and actions related to his care. However, there is relatively little research in this area. OBJECTIVE: To evaluate the empowerment of hospitalized patients with regard to their medication safety. METHODOLOGY: This is an exploratory and descriptive research with a quantitative approach, in the rehabilitation and rehabilitation unit in the state of Goiás. Data collection was performed through the application of a questionnaire composed of statements on a 5-point Likert scale, between the months of October to November 2019, with patients admitted to the health unit as participants. RESULTS: Among 48 participating patients, 28 were male, with a mean age of 34 years and a low level of education and income. It is noteworthy that 75.0% of respondents reported trusting those who administer the medication, and 33.3% stated that they never check the medication. DISCUSSION: Given the perception of the participants in this study, it can be seen that few have incorporated active roles in care, especially in the medication administration stage. The patient had gaps in knowledge about the medications he receives at the hospital, he trusts the medication administrator, and his involvement in the care proved to be fragmented and insufficient to ensure his safety, being justified by not understanding the importance of his role. CONCLUSION: Patient empowerment is a strategy for reducing medication errors, however, it still needs ample awareness, dissemination and incentive to significantly increase their involvement and co-responsibility, resulting in an active participation in their care.
Análise bacteriológica de staphylococcus spp. isolados de placas ortopédicas implantáveis, antes do processamento pelo serviço de saúde
(Universidade Federal de Goiás, 2019-12-12) Carvalho, Amanda Soares de; Vasconcelos, Lara Stefânia Netto de Oliveira Leão; Vasconcelos, Lara Stefânia Netto de Oliveira Leão; Costa, Dayane de Melo; Vieira, José Daniel Gonçalves
Healthcare Related Infections (IRAS) represent a serious public health problem and are among the leading causes of morbidity and mortality in the world. Among the types of HAI are Surgical Site Infections (SSIs) that may be due, for example, to the use of contaminated health products. In orthopedic surgeries, the occurrence of SSI is a serious complication for patients and may be associated with the use of contaminated implantable orthopedic plates. As these are critical health products that come into contact with tissues that do not have their own microbiota, they must be submitted to the sterilization process prior to use. However, failures in the processing steps, especially cleaning associated with biofilm formation in these devices, may prevent the implant from being properly sterilized. This study aimed to characterize the contamination profile of implantable orthopedic plaques by Staphylococcus spp., Before processing by the health service, and was carried out at a public teaching hospital in Goiânia, Goiás, from May to December 2018. Five Orthopedic surgical implant boxes called “Small Fragments”, provided by a consignment / lending system company, were selected 15 smaller implantable orthopedic plates collected using aseptic technique. They were submitted to bacteriological analysis for isolation and phenotypic identification of Staphylococcus spp., As well as evaluation of antimicrobial susceptibility profile. Among the evaluated implantable orthopedic plates, four (26.7%) were contaminated with Staphylococcus spp., And a total of four isolates were recovered. The most isolated species was Staphylococcus hycus (50.0%). Staphylococcus epidermidis (25.0%) and coagulase-negative Staphylococcus (25.0%) were also isolated. The microorganisms were sensitive to the evaluated antimicrobials, except Staphylococcus hyicus, which was resistant to cefoxitin, predicting methicillin / oxacillin resistance. These data point to the importance of properly performing the processing steps of these implants, considering the capacity of isolated microorganisms to form biofilm, especially when the implant presents non-conformities such as grooves, dirt, oxidation and other factors. The formation of biofilms in these devices may lead to the occurrence of chronic, severe and difficult to treat infections.
Atividade antifúngica na espécie Murraya paniculata (L.) Jack - uma revisão sistemática de literatura
(Universidade Federal de Goiás, 2021-05-28) Santos, Carine Fernandes dos; Souza, Warlles Filgueira; Abrão, Fernando Yano; Abrão, Fernando Yano; Martins, Christiane França; Silva, Liliane de Sousa
Yeast infections affect millions of people annually, especially immunocompromised patients. The existing treatment, although effective, presents problems such as the risk of causing toxicity, and the generation of fungal strains resistant to medicine drugs. Therefore, there is a need for new compounds capable of treating fungal infections more safely and effectively, and natural products become a viable alternative. The products of plant origin have a high molecular variety in their metabolites and are widely used in the search for new bioactive molecules. In this context, Murraya paniculata (L.) Jack, is a possible source of active molecules. The objective of this work was to make a systematic bibliographic review to verify the antifungal activity of extracts and essential oils obtained from Murraya paniculata. Six articles related to the subject matter were found and the studies demonstrate antifungal potential both of extracts obtained from leaves and of essential oils, with emphasis on the compound β-Caryophyllene, being one of those responsible for the antimicrobial action. Using the in vitro methodology, the following fungi were tested: Aspergillus flavus, A. fumigatus, A. niger, A. parasiticus, Candida albicans, Cryptococcus neoformans, Fusarium solani and Microsporum gypseum, and it was found that although there is an antifungal potential for M. paniculata, more specific studies are needed regarding the molecule responsible for antifungal activity, as well as the purification of compounds from the extracts obtained.
Atividade antioxidante da vitamina c: aplicações na indústria farmacêutica e de alimentos e formas de evitar a oxidação mantendo sua estabilidade
(Universidade Federal de Goiás, 2020-12-17) Vieira, Ana Carolina da Rocha; Silva, Aline Gomes de Moura e; Silva, Aline Gomes de Moura e; Rodrigues, Ilana Carneiro; Alves, Izabel de Paula Duarte
Ascorbic acid, known as vitamin C, is a water-soluble, unstable vitamin, easily eliminated by some factors such as: heat, improper storage, the presence of metals and others. The human body does not synthesize this vitamin, its ingestion occurs through food, such as vegetables and fruits. Vitamin C is a powerful antioxidant, vital for the functioning of cells and this is particularly evident in connective tissue, it acts in the prevention of several pathologies such as scurvy, premature aging. Classified as a natural antioxidant, vitamin C has been used mainly in the food industry, because in addition to its nutritional role, it is applied for its antioxidant action, preserving the flavor and natural color of food, besides being used as an additive in meat cured, accelerating the curing process, preventing formation of nitrosamines and inhibiting the growth of microorganisms, among other applications. Antioxidants provide natural protection to the human body, as they neutralize the harmful effects of free radicals. Because vitamin C has an effective effect as an antioxidant, it has become widely recognized by the pharmaceutical industry, as it is used in cosmeceutical, dermatological formulations and in medicines, has an action in preventing and reversing premature aging, acts as a depigmentant, synergistic action with sunscreens and anti-inflammatory effect in dermatitis treatments. The application of vitamin C in cosmetic products makes it possible to reach levels that would not be possible with food, since its topical use is a major target of the cosmetic industry, generating satisfactory results in the treatment of skin changes caused by aging, however, it has barriers when incorporated in systems for topical use as it is difficult to stabilize. Maintaining the stability of vitamin C has become a challenge, however some strategies have been developed to avoid instability in the formulation, such as: controlling oxygen at low pH, adding preservatives, stabilizing agents, using vitamin C derivatives and technologies, such as microencapsulation.
Atuação do farmacêutico em ambulatório de oncologia: uma experiência no cuidado ao paciente
(Universidade Federal de Goiás, 2020-08-13) Leão, Denise da Silva; Lopes, Angela Ferreira; Lopes, Angela Ferreira; Barbosa, Jakeline Ribeiro; Ribeiro, Luane da Silva
Introduction: The beginning of cancer treatment is a period with many doubts and fears, so the offer of health education services aims to reduce doubts about treatment in order to improve patient compliance and safety. Objective: To report the importance of the care of the pharmaceutical professional in health education in an oncology outpatient clinic and to present patients' doubts about chemotherapy in a project of a hospital specializing in oncology in the Midwest. Methodology: This research was developed through: a) literature review of articles published from 2006 to 2018, in the PUBMED, LILACS and CAPES databases using the terms: pharmacist, pharmaceutical services, chemotherapy, health education, for the selection of articles; b) research through the non-participant observation technique, in conjunction with public meetings promoted to cancer patients treated in the project of a referral hospital in oncology in Goiás. Results: The results obtained through the literature review, as well as the participation in public meetings, they demonstrated that the pharmacist's performance with the multiprofessional health team can promote the effectiveness of the treatment. Conclusion: The performance of pharmacists in oncology brings positive results in drug therapy.
Avaliação da capacidade antioxidante em amostras comerciais de canela por métodos voltamétricos e espectrofotométricos
(Universidade Federal de Goiás, 2022-08-16) Vasconcelos, Igor André Alves; Gil, Eric de Souza; Moreno, Emily Kussmaul Gonçalves; Moreno, Emily Kussmaul Gonçalves; Silva, Giovanna Nascimento de Mello e; Machado, Fábio Bahls
This study aimed to analyze the antioxidant capacity in commercial cinnamon (Cinnamomum sp.), given the growing concern about cellular damage from reactive oxygen species, as well as the desire for healthy and natural food, aiming to compare traditional and innovative methods for the determination of antioxidant capacity. The traditional methods performed were the scavenging of the free radical DPPH (1,1-diphenyl-2-picrylhydrazyl) and the capture of the cation of the radical ABTS (2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate), measured by the spectrophotometry technique. For electrochemical studies, voltammetric techniques such as CV, DPV and SWV were performed and the Electrochemical Index (IE) was calculated. The results of ABTS, DPPH and IE indicated significant differences between the 17 samples. A matrix was calculated, comparing the methods, where it was possible to observe a high statistical correlation (c.a 0.6) between them. It was concluded that the cinnamon samples have high antioxidant capacity and the methodologies used are equivalent.
Avaliação da citotoxicidade e internalização celular in vitro de nanopartículas poliméricas contendo melatonina em células de glioblastoma multiforme U87MG
(Universidade Federal de Goiás, 2020-12-09) Salomão, Mariana Arraes; Oliveira Júnior, Edilson Ribeiro de; Oliveira Júnior, Edilson Ribeiro de; Silva, Luís Antônio Dantas; Silva, Artur Christian Garcia da
Glioblastoma multiforme (GBM) is a malignant primary brain tumor, with low prognosis profile. Moreover, GBM is responsible for about 4% of cancer-related deaths. Currently, the treatment of GBM consists on surgical removal of the tumor followed by radiotherapy and chemotherapy. It has been reported in the literature the antitumor activity of melato- nin (MLT) for the treatment of GBM. In addition, the use of nanoparticles, as drug carries, have improved the targeting of drugs to the central nervous system. This study aimed to evaluate the in vitro cytotoxicity and cellular uptake of melatonin-loaded polymeric nano- particles in human GBM cell line (U87MG). The cytotoxicity of formulation was evaluated by the MTT assay. The cellular uptake of nanoparticles was observed by fluorescence microscopy and flow citometry. The results noticed that MLT demonstrated a selective cytotoxic activity against U87MG cells when encapsulated in the particles. These results may be justified by the facilitated cellular internalization of the nanoparticles and the re- lease of MLT over time. In conclusion, the nanoencapsulation was crucial for the selective cytotoxic activity of MLT in U87MG, representing a promising strategy for the treatment of GBM.
Avaliação da evolução de compostos fenólicos durante o amadurecimento de frutos de três variedades de Eugenia uniflora
(Universidade Federal de Goiás, 2021-10-28) Pereira, Marx Osório Araújo; Santos, Suzana da Costa; Santos, Suzana da Costa; Ferri, Pedro Henrique; Paula, José Realino de
Surinam cherry (Eugenia uniflora L., Myrtaceae) is a highly appreciated fruit in Brazil and for better use of its nutraceutical and medicinal potential it can be processed into jams or other forms. In order to increase the knowledge about the bioactive compounds of this species, the variability of secondary metabolites during the maturation of fruit seeds and skin/pulp of three varieties of E. uniflora was evaluated. Quantifications of tannins, flavonoids, anthocyanins and carotenoids were performed by HPLC and UV-VIS absorbance. The results obtained were compared by ANOVA (Multivariate Statistical Analysis). The peel/pulp extracts showed greater complexity of constituents: carotenoids, anthocyanins, flavonoids and tannins, while only tannins were identified in seeds, but in quantities of ten to one hundred times greater. The red-orange variety had the highest contents of phenolic compounds in both parts of the fruit, with the exception of the cyanidin-3-glycoside pigment which was higher in the purple variety. Flavonoid and tannin contents decreased in contrast to pigment increase during peel/pulp maturation in the three varieties, while in seeds the major tannin, oenotein B, increased up to 1.32g/100g. Thus, the medicinal use of pitanga depends on the part of the fruit used, the variety and the degree of ripeness.
Avaliação da sobrevivência in vitro de Lactococcus lactis QMF 11 em presença de sais biliares como critério de atividade probiótica
(Universidade Federal de Goiás, 2020-08-21) Silva, Cynthia Costa; Alves, Virgínia Farias; Alves, Virgínia Farias; Pereira, Marita Gimenez; Costa, Ana Carolina Cabral Carvalhaes
Lactic acid bacteria (LAB) have been extensively studied due to their probiotic potential. One important criteria for selecting probiotic cultures for human use is resistance to the harsh environmental conditions encountered during transit through the gastrointestinal tract (GIT). In order to reach their site of action, the large intestine, in adequate numbers to exert the probiotic effect. An important biological barrier in GIT are the bile salts present in the small intestine, as bile salts have the ability of disorganizing the cell membrane structure, thus causing damage to the genetic material of microorganisms. The objective of this work was to evaluate the survival of Lactococcus lactis QMF 11, a bacteriocinogenic strain derived from a dairy product, against bile salts as an initial indicator of probiotic activity. For that, L. lactis QMF 11 was grown in MRS broth in pH 8,0 in the presence of 0,3% and 0,5% (w/v) of bile salts. Colony counts were performed at times zero, 90 and 180 min. The results indicated that L. lactis QMF 11 remained viable throughout the trial, in numbers greater than 7.58 Log CFU/g, with a survival rate at the end of the study of 100 and 88%, respectively, in the presence of 0,3 and 0,5% bile salts. These results suggest that L. lactis QMF 11 may be a promising microorganism for use as a probiotic culture.
Avaliação da toxicidade aguda do extrato padronizado em psoraleno e bergapteno a partir de Brosimum gaudichaudii Trécul. usando os estágios embrio-larvais de zebrafish (Danio rerio)
(Universidade Federal de Goiás, 2020-07-16) Silva, Hugo Santiago Francisco da; Oliveira, Gisele Augusto Rodrigues de; Oliveira, Gisele Augusto Rodrigues de; Silva, Gloria Narjara Santos da; Costa, Gessyca Gonçalves
Brosimum gaudichaudii Trécul. is a plant of the Moraceae family, often found in the savannahs of the states of Goiás, São Paulo and Mato Grosso, which contains furanocoumarins, mainly psoralen and bergaptene, responsible for skin repigmentation, so it can be used in the treatment of skin disease, like vitiligo. Herbal medicines must undergo toxicological studies in order to prove the safety of these medicines. This study aimed to evaluate the acute toxic effects (lethal and sublethal) of the standardized extract in psoralen and bergaptene from B. gaudichaudii Trécul. on the embryo-larval development of zebrafish. For this purpose, the acute toxicity test was performed with embryos and zebrafish larvae - Fish Embryo Toxicity Test (OECD 236, 2013). Twenty independent eggs were exposed in triplicate for each concentration of the extract and negative control (water from the maintenance system). The toxicity profile of the extract was time-dependent and concentration-dependent and the sublethal effects observed were: pericardial edema, yolk sac edema, lack of body pigmentation and inhibition of hatching. Therefore, it was possible to conclude that the extract is embryotoxic for zebrafish, with significant lethal effects from the concentration 0.005 µg / mL in 72 hours of exposure, in addition to relevant malformations throughout the period of exposure.
Avaliação de diferentes condicionadores quanto ao perfil de textura e resistência a tração de cabelos
(Universidade Federal de Goiás, 2019-12-09) Borges, Ohary de Sousa; Mata, Sara Cardoso da; Diniz, Danielle Guimarães Almeida; Diniz, Danielle Guimarães Almeida; Páscoa, Henrique; Silva, Luis Antônio Dantas
Human hair is characterized by being a complex integrated system of various morphological components that act as a unit. It has in its composition three main components which are the cuticle, the cortex and the medulla. There are several factors that damage the hair fiber among them are solar radiation, combing, pollution, endogenous factors, cleaning, chemical treatments such as dye, straightening and cauterization. Cosmetic hair treatments such as conditioners alter some of the physical properties of hair, as they act by depositing themselves in the cuticles, reaching the cortex, determining mechanical properties of the fiber, such as strength and elasticity. Thus the present study aimed to evaluate three different commercial conditioners with respect to texture analysis (Back Extrusion), tensile test and microscope analysis. Through the tests performed it was possible to determine viscosity indexes, firmness, cohesiveness and consistency of the conditioners, as well as the tension of the wires in relation to the tensile, rupture, and their mode of elasticity. The conditioners partially met their objectives of improving hair properties, however there were no significant differences between the samples analyzed regarding the maximum tensile strength. Currently, there are few studies evaluating the activity of conditioners. Thus, it is necessary to develop new research, as well as open space for discussion, since it is a topic of its relevance and needs to be further explored.
Avaliação do emprego de nanotecnologia à formulações de uso oral de aciclovir
(Universidade Federal de Goiás, 2023-02-09) Santos, Yanka Machado de Paula; Diniz, Danielle Guimarães Almeida; Diniz, Danielle Guimarães Almeida; Silva, Luís Antônio Dantas; Pascoa, Henrique
Acyclovir is an antiviral from the class of nucleoside analogues, which has selective action against Herpes Simplex virus types 1 and 2 (HSV 1 and HSV2) and against Varicella-Zoster virus (VZV), being chosen as the gold standard for treatment of these pathologies. Is used to treat primary herpes by reducing the duration of symptoms, but its low oral absorption resulting from low solubility and permeability implies the frequent use of high doses, which increases the chances of adverse effects and reduces adherence to treatment. Due to the potential characteristics of nanometric systems, this approach has been studied as a strategy for delivering, improving solubility and sustained release of Acyclovir. In view of this, this work aimed to evaluate the use of nanotechnology as a strategy to improve the oral bioavailability of the drug Acyclovir, through a bibliographic survey. A limited number of works were found when it comes to improving oral bioavailability, but the reported nanometric systems proved to be promising, such as the use of polymeric nanoparticles, mucoadhesive polymers, solid lipid nanoparticles, nanoemulsions and the association of different techniques such as the use of nanocrystals. Therefore, nanotechnology has demonstrated results that can help to offer a more effective treatment for the oral use of acyclovir.
Avaliação do teor de fenóis totais, flavonoides totais e hibalactona nas partes aéreas de Hydrocotyle umbellata L. (Araliaceae)
(Universidade Federal de Goiás, 2020-07-07) Oliveira, Fernanda Miguel de; Paula, José Realino de; Paula, José Realino de; Borges, Leonardo Luiz; Silva, Liliane de Sousa
Hydrocotyle umbellata L., popularly known as "acariçoba", is a species belonging to the family Araliaceae, native to the American continent. The anxiolytic, antinociceptive and antiinflammatory activities were demonstrated for the subterraneous parts of H. umbellata and these activities were in part attributed to the presence of the lignan hibalactone. The objective of this work was to carry out quality control studies and determine the content of total phenols, total flavonoids and hibalactone in the aerial parts of H. umbellata. An appreciable amount of phenolic compounds and flavonoids was observed (3,54% and 3,04%). The co-validation of the HPLC method for quantification of hibalactone proved to be selective, linear and accurate, being useful for its quantification in the plant drug of aerial parts of H. umbellata. The best conditions for the ultrasound extraction of hibalactone, obtained from the Box-Benhken design associated with the response surface methodology were: solid-liquid ratio of 0.9 g/10 mL, 67% ethanol content (v/v) and extraction temperature of 64 °C. The content of hibalactone found in the aerial parts was lower than that reported for the subterraneous parts, however more studies must be carried out to investigate the possibility of using therapeutically the subterraneous and aerial parts of the plant.
Avaliação preliminar da influência do método de preparo e da composição da formulação nas características físico-químicas e estabilidade cinética de carreadores lipídicos nanoestruturados delineados como sistemas para liberação cutânea da leflunomida
(Universidade Federal de Goiás, 2022-08-15) Souza, Wayane Karuena Gomes de; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Mello, Bianca Bueno Fontanezi Dias; Diniz, Danielle Guimarães Almeida
Rheumatoid arthritis (RA) is an autoimmune disease that causes joint degeneration and leads to loss of function in the area. One of the drugs associated with its treatment is leflunomide, a drug that belongs to the isoxazole class and inhibits the enzyme dihydroorotate dehydrogenase. However, it has adverse events that can make its use unfeasible. Thus, topical administration is a promising alternative and for this, the development of nanoformulations is an option. Lipid nanosystems have the advantage of accommodating the drug in their structure and can be developed by different methods. The objective of this work was to evaluate the influence of preparation methods and composition of nanostructured lipid carriers (NCL). Emulsification and solvent evaporation and emulsification melting methods were used, associated with the use of a microfluidizer or sonicator. Parameters were evaluated in relation to size and polydispersity index (PDI), by DLS method, and stability for 7 days was evaluated. The average size of 163.4 nm was obtained, with a PDI of 0.301, but there was a tendency for these parameters to increase during stability, being significant after four days, which may be associated with the nanocarrier formulation. More studies should be carried out in order to optimize production and formulation parameters.
O avanço do desenvolvimento de vacinas e o reflexo da sua importância na sociedade: uma pesquisa bibliográfica
(Universidade Federal de Goiás, 2021-10-29) Almeida, Morganny Dutra Alves de; Silva, Luís Antônio Dantas; Silva, Luís Antônio Dantas; Sales, Marcelle Figueira Marques da Silva; Pascoa, Henrique
This paper presents a literature review on the line of research in the concept of vaccines and their generations, the beginning of vaccine development practice, the nanobiotechnology tools used as strategies for development and socioeconomic impact. Vaccines are considered the main strategy for preventing disease and thus reducing mortality and avoiding the need for expensive treatments and hospitalizations. Its process and development will become more complex every year, ensuring better quality and greater safety. Along with the advancement of technology, vaccines have become more effective, efficient, safe, lower cost with the shortest time for production and affordable to the population. Nanotechnology has been helped and improved productivity, stability and better access to the population it serves. In order to demonstrate the stages of development and innovation of vaccines and their improvements and how it reflects on today's society, through literary analysis published in articles and gray literature.
Bacilos gram-positivos isolados de implantes cirúrgicos ortopédicos consignados em uso na prática clínica antes do processamento pelo serviço de saúde
(Universidade Federal de Goiás, 2020-12-04) Silva, Emerson Oliveira; Oliveira, Natalia Rodrigues; Vasconcelos, Lara Stefânia Netto de Oliveira Leão; Vasconcelos, Lara Stefânia Netto de Oliveira Leão; Vieira, José Daniel Gonçalves; Ribeiro, Evandro Leão
Surgical Site Infection (SSI) is a public health problem. One of the important measures for its prevention is the reprocessing of surgical reusable devices, such as orthopedic implants, for instance plates and screws. These, despite classified as single-use, are submitted to multiple reprocessing until they are implanted in the patient, exposing them to physical, chemical and biological agents, favoring the formation of biofilm on these devices, thus compromises the patient safety. Therefore, this study aimed to characterize phenotypically Gram-Positive Bacilli (GPB) isolated from loaned orthopedic implants (plates and screws) in use in clinical practice, before reprocessing by the healthcare service, as well as to determine the susceptibility profile of isolated bacteria to antimicrobials. The study was carried out from May 2018 to September 2019, at the Sterilizing Service Unit of a general teaching hospital located in the state of Goiás, linked to the Unified Health System (SUS). Fifteen plates and 15 screws were collected from five boxes of surgical orthopedic instruments/implant, named “Small Fragments”, totaling 30 implants. The implants were subjected to bacteriological analysis according to standard procedures for the isolation and identification of BGP, as well as the evaluation of the susceptibility profile of the isolates to antimicrobials. Of the 30 implants evaluated, 12 (40.0%) were contaminated with BGP, with 50.0% plates and 50.0% screws. One BGP was isolated per implant (n = 12), nine (75.0%) of which were identified as Bacillus sp. and three (25.0%) as from the Corineformes group. All (100.0%) BGPs were resistant to penicillin and oxacillin and/or cefoxitin, and 83.3% (n=10) were resistant or intermediate to clindamycin, and nine (75%) to rifampicin. One BGP was resistant or intermediate, concomitantly, to eight (66.7%) of the evaluated antimicrobials. All (100.0%) isolates were sensitive to ciprofloxacin. In conclusion, BGP (Bacillus sp. and Corineforme group), including multidrug-resistant, were identified on implantable orthopedic plates and screws acquired through loaner system, upon delivery to the healthcare service and before processing. The findings of this study point to the need for new policies that address the management of these implants, in order to provide safe surgical reusable devices that, instead of adverse events, bring benefits to the patient.
Bactérias tolerantes a metais
(Universidade Federal de Goiás, 2021-05-25) Saêta, Venine Prado; Carneiro, Lilian Carla; Carneiro, Lilian Carla; Gama, Aline Rodrigues; Santos, Mônica de Oliveira
Heavy metals are widely distributed in the environment, and may can find natural, industrial, agricultural and other origins. The accumulation of these metals in water bodies is related to several environmental issues, especially regarding the quality of drinking water. Therefore, the general objective of this study was to isolate, identify and characterize bacteria tolerant to nickel and cobalt metals present in raw water samples and in the sediment of the Rio Traíras - Niquelândia (GO). A total of 68 bacterial isolates were obtained, which were submitted to the microdilution method to determine the minimum inhibitory concentration (MIC). Based on the results found, 12 bacterial choices were chosen, which internationally higher and lower tolerance, being classified according to their microscopic and tinting characteristics. According the results obtained, it is possible to observe the tolerance of isolated bacteria to high concentrations of metals, suggesting its use as a biotechnological tool for the remediation of contaminated areas.
Caracterização fenotípica de Staphylococcus spp. isolados de ambiente hospitalar veterinário em Goiânia-GO
(Universidade Federal de Goiás, 2020-12-18) Silva, Giovanna Pereira Teixeira; Carvalho, Lucas Kalebe Mateus de; Silva, Carla Afonso da; Silva, Carla Afonso da; Sousa, Jéssika Munira Gonçalves de; Pinto, Ricardo Marques
The bacterial community and the incidence of nosocomial infection are not well estab-lished in veterinary medicine mainly due to the lack of nosocomial infection control commis-sions. Staphylococcus spp. that cause infections or that colonize healthy people already have a prevalent resistance to the drug penicillin, in addition to significant resistance to other drugs, such as methicillin, which makes treatment difficult in cases of infection. Therefore, there is a need to identify and characterize phenotypically bacteria in veterinary hospital environments, in order to monitor resistance to antibiotics most used in clinical routine. The bacteria evaluated in this study were isolated from laboratory environments of a veterinary hospital in the city of Goi-ânia-GO and sent to the Bacteriology Laboratory of the Institute of Tropical Pathology and Pub-lic Health of the Federal University of Goiás (IPTSP / UFG), where the samples were processed , identified and submitted to the antibiogram test. Twenty-two Staphylococcus bacteria were isolated, with the species S. haemolyticus 50% being the most frequent, followed by S. hominis novobiosepticus 14% and S. hominis hominis 14%. In the antibiogram result, 36.4% of the isolat-ed strains were sensitive to all tested antibiotics and 63.6% were resistant to at least one antibi-otic. The isolated strain of S. aureus was multidrug-resistant. The results of the present study demonstrated the need for constant monitoring of the bacterial resistance profile in veterinary hospitals, which lack information in the scientific literature.

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