Doutorado em Ciências da Saúde (FM)

URI Permanente para esta coleção

http://200.137.215.59/tede/handle/tde/243

Navegar

Agora exibindo 1 - 20 de 251

Parâmetros hematológicos e concentração de óxido nítrico salivar em atletas de Jiu Jitsu: um estudo observacional
(Universidade Federal de Goiás, 2016-05-09) Agricola, Nestor Persio Alvim; Guillo., Lidia Andreu; http://lattes.cnpq.br/3401436781775091; Guillo, Lidia Andreu; Silva, Maria Sebastiana; Barbosa, Maria Alves; Soares, Viviane; Rita, Ricardo de Mattos Santa
Physical exercise is considered an important variable in the study of human health, especially due the changes induced in several biomarkers. In physical training, body adaptations are quite specific for each type of sport and effort. The quantification of biochemical parameters related to human health, mediated by physical activity in its many variations, provides new scientific eyes, not only for what relates to the interaction between the various systems, but also in relation to physiological and adaptive effects generated by them. This research consists of the systematic monitoring of Jiu Jitsu athletes, quantifying the variations of some biochemical parameters linked to health, in an attempt to assess the modality of sport in its potential for health and verify the variations in these parameters depending on the type and intensity of the effort and the special characteristics of the sport. Jiu Jitsu is a kind of sport that has gained prominence and become popular. Throughout the year of training, athletes alternate periods of high intensity training with low intensity periods. The energy expenditure is high and the maximum or submaximal effort often leads to muscle, joint and bone injuries. This is a longitudinal descriptive observational study of measurement that had the participation of 14 volunteers who were monitored for 9 months in their training routine. Blood and saliva samples were collected and the heart rate was monitored throughout this period. Saliva was used to quantify nitric oxide and blood for hematological parameters. The results of the experiments were submitted to statistical tests. Hematological parameters of the red series are influenced by the physical effort when performed in a long-lasting mode, during the training period, responding to the intensity of the effort made. The white series, related to the immune system, is influenced acutely, responding to the exercise stimulus with significant changes as the effort is more or less intense. The production of NO in the organism tends to follow the level of effort made; however, the modality studied has the characteristic of promoting the stimulation of the sympathetic nervous system, what reduced the activity of salivary gland and nitrite concentrations after training is performed. Musculoskeletal injuries are typical of this kind of sport and very typical, which ends up modulating partly the organic response to training. This stimulation, however, must be seen as positive for activating the adaptive response and the interaction of several systems.
Perfil dos idosos do município de Goiânia-GO e associação a hiperglicemia, dislipidemias e qualidade de vida
(Universidade Federal de Goiás, 2014-03-31) Alcanfôr, Joana D´Arc Ximenes; Costa, Sérgio Henrique Nascente; http://lattes.cnpq.br/1104711925118993; Cunha, Luiz Carlos da; http://lattes.cnpq.br/6349547031976679; Cunha, Luiz Carlos da; Monteiro, Valdirene Neves; Lopes, Flávio Marques; Féres, Valéria Christina de Rezende; Mendonça, Reginaldo Teixeira
Introduction: The prevention of chronic diseases of the elderly population characteristics involves the control of modifiable risk factors through changes in lifestyle inadequate.Objective: Analyze the Elderly Population Profile of the municipality of Goiânia, including the relationship between glucose, lipid profile components and style of life. Methods: The target population consisted of 220 elderly, noninstitutionalized who provided data on weight, height, lifestyle, and self-reported diseases, which responded to the SF-36 questionnaire and whose blood was collected to perform fasting and lipid profile. Results: From the data analysis it was found that 61.36 % of the elderly (135/220) were female. Only 25.9 % (57 /220) reported the practice of at least one physical activity; 7.72 % (17 /220) were taking lipid-lowering. The median total cholesterol was 195.5 mg/ dL; HDL-cholesterol was 40 mg/dL and triglycerides of 145 mg/dL. The mean total cholesterol of 17 seniors who were taking lipid-lowering was 161.1 mg/dL, HDL-cholesterol of 42.4 mg/dL and triglycerides, 161.3 mg/dL. BMI was ≥ 30 to 12.2 % (27 /220) of the elderly, with a median concentration of triglycerides was 181 mg/dL, while for those with BMI<30 (n=184) the median was 144mg/dL (48.0 to 491.0 SD=79.8) (p > 0.05). The frequency of hyperglycemia was 13.60% (30/220) and 16.5% (36/220) had intermediate hyperglycemia. The ingestion of alcohol interfered with blood sugar of the elderly (p < 0.05). Obese and elderly had low physical activity self-reported diabetes more often than elderly males (p < 0.05). Regarding quality of life according to the SF-36 questionnaire self-reported diabetes influenced the social aspects of the elderly. Obese elderly had harmed the emotional aspects and older who smoked improperly presented complications for mental health (p < 0.05). Conclusions: The results indicate that both hyperglycemia and dyslipidemia in elderly reach levels that demonstrate the need for immediate intervention by means of promoting public health policies, the city studied, both in health care and in taking preventive measures aimed at comprehensive approach to risk factors for these diseases and thereby improving the quality of life.
Avaliação do conhecimento e capacitação de profissionais da Atenção Primária sobre doença pulmonar obstrutiva crônica
(Universidade Federal de Goiás, 2017-02-01) Alcântara, Erikson Custódio; Corrêa, Krislainy de Sousa; http://lattes.cnpq.br/9231180941258607; Rabahi, Marcelo Fouad; ttp://lattes.cnpq.br/1489771770609266; Rabahi, Marcelo Fouad; Jardim, José Roberto de Brito; Taleb, Alexandre Chater; Queiroz, Maria Conceição Castro Antonelli Monteiro de; Barbosa, Maria Alves
Background: Video Lesson is a multimedia system, with text narration and illustration, capable of promoting the training of Primary Care professionals. To evaluate the effect of training, an assessment tool is needed, however, there are no validated instruments that measure knowledge about Chronic Obstructive Pulmonary Disease (COPD) among these professionals. Objective: Validate a knowledge questionnaire about COPD for Primary Care professionals and train them on chronic obstructive pulmonary disease. Methods: Initially, a methodological study was carried out with 88 Primary Care professionals to elaborate and validate a questionnaire. Then, quasiexperimental study with 36 primary care professionals in order to enable them, through videotapes. The knowledge of the professionals was measured before, shortly after and three months after being trained by the "Primary Care - COPD Knowledge Questionnaire (QAP-COPD)". To analyze the reproducibility and reliability of the questionnaire, the Kappa and α Cronbach tests were applied respectively. In the evaluation of the knowledge, the tests of Friedman and Tukey a posteriori, Bonferroni correction and the χ2 test were used. A significance level of 5% was adopted. Results: The questionnaire presented reproducibility in most items (87.5%) from good to excellent (Kappa: 0.61 - 0.88) and reliability with α Cronbach = 0.763. Of the 16 items in the questionnaire, the professionals who indicated the "agree" option, before the training, soon after opting for the "totally agree" option, in 11 items (68.8%). Fourteen items had a significant difference before and after training, but in the moments just after and three months after the training, 14 items did not present significant differences. The median score of the participants' questionnaire increased from 60 points before training to 77 shortly after and three months after training (p <0.001). In the three months after there was no significant statistical difference, in relation to the soon after (p = 0.38). Conclusions: The questionnaire met the psychometric properties and proved to be reproducible and reliable in the evaluation of knowledge about COPD among primary care professionals. The videotaped training presented satisfactory results observed by the good performance of the knowledge of Primary Care professionals, before and shortly after the training and the maintenance of this knowledge after three months of the training program.
Estudo randomizado testando musicoterapia na redução da fadiga relacionada ao câncer em mulheres com neoplasia maligna de mama ou ginecológica em curso de radioterapia
(Universidade Federal de Goiás, 2012-04-05) Alcântara-Silva, Tereza Raquel de Melo; Freitas, Nilceana Maya Aires; http://lattes.cnpq.br/3872749814487965; Freitas Júnior, Ruffo; http://lattes.cnpq.br/7343840830786566; Freitas Junior, Ruffo; Filassi, José Roberto; Silva, Laura Franch Schimidt da; Mota, Dálete Delalibera Corrêa de Faria; Conde, Délio Marques
To study the influence of music therapy in reduction of Fatigue related to cancer in patients with breast’s or gynecology’s cancer, during the radiotherapy treatment. METHODS: This is a randomized controled study (Control Group - CG e Musictherapy Group - MTG) wich values fatigue, life’s quality, anxienty, depression by using evaluative instruments Functional Assessment of Cancer Therapy: Fatigue (FACT-F), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) in three differents moments (during first week of radiotherapy, in the intermediate phase’s week and during the last week of radiotherapy) for patients of bouth groups. Women allocated in MTG, in addition to the scales described above, answered the Music therapy Questionary (MQ), and the Subjective Impression of the Subject’s Questionary in last meeting. Music Therapy sessions were individual and lasted an average of 40 minutes. Music therapeutic techniques used were Musical Audition (MA) and Therapeutic Musical Audition (TMA). RESULTS: 164 women were randomized and 116 women with middle age of 52,9 (CG) and 51,85 years (MTG) were included in the analysis. MTG’s patients had on average 10 music therapy sessions, totalizing 509 assistences during the search. In the analysis between groups, Functional Assesment of Cancer Therapy: Fatigue (FACIT-F) demonstrated significance related to Trial Outcome Index (TOI) (p=0,011), Functional Assesment of Cancer Therapy – Geral (FACT-G) FACT-G (p=0,001) FACIT-F FACT-F(p=0,005) areas to the MGT compared to CG. In comparisson made inside the same group results pointed a significant worsening for women. The GMT showed a significant in TOI, FACT-G and FACIT – F (p<0,001) areas in fatigue scale. Music Therapy Questionary showed that 59,3% of the pacients didn’t know what music therapy was, and 53,7% thought that Music Therapy was a relaxing activity. In the end of the process, based on ISS, 98,1% of the women afirmated that Music Therapy made difference in their lives, 96,2% reported a positive perception of music therapy, 75,5% noticed less fatigue and 84,9% reported less stress. CONCLUSION: Individual Music therapy is effective in treatment of Fatigue Related to Cancer during the radiotherapy, to depression and to improve quality of life.
Investigação da acalásia do esfíncter anal interno por meio da eletromanometria de pacientes chagásicos obstipados com e sem megacolo (Goiânia-Goiás-Brasil)
(Universidade Federal de Goiás, 2012-02-02) ALMEIDA, Arminda Caetano de; MOREIRA, Marise Amaral Rebouças; http://lattes.cnpq.br/6390358577348486
Chagas disease remains as an important public health challenge in South America. The Chagas colopathy is considered the second clinical digestive manifestation most common of the disease and constipation chronic, its main symptom. The general objective was to investigate the presence of achalasia, through electromanometry of the internal anal sphincter, in constipated chagasic patients with and without megacolon. This study evaluated clinical and electromanometry parameters of 64 patients with symptoms of constipation, attended on the service of coloproctologya on a university hospital in Brazil, central region. The achalasia was present in 91.3% (IC95% 74.13 to 98.52) of patients with megacolon and/or megarecto (Group 1), in 47.29% (IC95% 27.29 to 68.57) without megacolon and/or megarecto (Group2), and was not present in patients of the control group (Group 3). The rectal capacity was 309.1, 159.2 and 150.1 ml in the groups 1, 2 and 3 respectively. In conclusion the electromanometry detects achalasia of the internal anal sphincter in almost totality of patients with megacolon and/or megarecto. The megacolon presence in constipated patients with Chagas Disease alert to the possibility of occurrence of achalasia on the internal anal sphincter. In chronically constipated patients with positive serology for Chagas Disease, without megacolon the a finding of absence of the recto anal inhibitory reflex, by electromanometry, can definitively prove the Chagas colopathy, while the presence of reflection departs, at the time, this diagnosis, should these patients be followed and treated like other patients with constipation due to other causes The comparison of clinical manifestations in the three groups not evidenced differences that could distinguish patients with Chagas colopathy those with functional constipation, reaffirming the importance of holding the electromanometry in Chagasic and constipated patients.
Síndrome metabólica no policial militar do estado de Goiás
(Universidade Federal de Goiás, 2017-01-28) Almeida, Suzy Darlen Soares de; Amaral, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Fernandes, Marcos Rassi; Franco, Glaucimeire Marques; Ferreira, Rui Gilberto; Castro, Eduardo Camelo de
OBJECTIVES: (i) to establish the prevalence of Metabolic Syndrome (MS) in Military Police Officers (PMs) in Goiás; (Ii) to characterize the epidemiological profile of Goiás MPs with MS; (Iii) establish its risk factors; (Iv) to establish a correlation between the prevalence of MS occurrences and police occurrences (v) to describe their spatial distribution according to the Safe Citizen Program of the State of Goiás. METHODOLOGY: A descriptive, retrospective and transversal study developed with Military Police officers of Military Police of Goiás using the study of a database for the periodic evaluations of the health status of the MPs carried out between 2009 and 2013. The sample was selected according to the selection criteria, which included those with cadastral information and multidisciplinary evaluations Complete and unpaid; And excluded those with cadastral data and incomplete, multi-disciplinary evaluations of the pregnant police officers; With duplicate and triplicate data; With misleading and incomplete typing. Total 6303 police officers, 52.5% of the total population of the study (94.5% in men and 5.5% in women), being distributed according to the regions of the Safe Citizen Program of the State of Goias. The research was divided into: 1st phase - Organization and data collection, 2nd Phase - Application of the diagnostic criteria for the National Cholesterol Education Program Revised, and 3rd Phase - Data analysis - descriptive statistics with spatial distribution using scanning scan of Kulldorff. RESULTS: Of the 6303 PM evaluated, 23.7% (n = 1495) had MS, divided into 22.6% of males and 1.1% of females. The majority were between 40 and 45 years of age (32.4%), with rates increasing above 20% from 35 years, decreasing at 55 years; Married (70.4%); With incomplete secondary education (45.1%); With physical activity below three times per week (55.2%); With Sergeant's patent (45.0%); Nonsmokers (89.8%); With normal sleep (92.1%); And Goiânia (30.3%). Of the components, 58.9% of blood pressure, 42.8% of triglycerides, 30.3% of High Density Lipoprotein, 20.9% of waist circumference and 17.4% of fasting glucose were found in the PMs. SM was not correlated with police occurrences. Body mass index and age were the risk factors associated with higher odds for MS, especially, aged between 40 and 45 years and overweight. The groups with the highest relative risk (1.22) were found in the regions of: Itumbiara, Cidade de Goiás, Iporá, Jataí and Rio Verde, and with the lowest relative risk (0.82) in Goiânia. CONCLUSION: The prevalence of MS among Goiás MPs was 23.7%, being more frequent in subjects aged 40-45 years, married, with incomplete secondary education, with physical activity below three times a week, Sergeants, nonsmokers, with normal sleep and crowded in Goiânia. The risk factors identified were BMI and age, respectively, the most potentiating classes, age between 40 and 45 years and overweight increase the association with MS. No correlation was found between this Syndrome and police occurrences.Concerning its spatial distribution, the biggest frequency were in the regions of: Águas Lindas de Goiás - 31.5%; Porangatu - 29.7%; Rio Verde - 28.9%; Itumbiara - 28.8%; And Iporá - 28.4%.
Níveis séricos e efeito da suplementação de vitamina D sobre a composição corporal e perfil metabólico de crianças
(Universidade Federal de Goiás, 2020-12-21) Alves, Ana Gabriella Pereira; Silva, Maria Sebastiana; http://lattes.cnpq.br/1329422634395496; Silva, Maria Sebastiana; Hadler, Maria Claret Costa Monteiro; Guillo, Lídia Andreu; Santos, Renata Carvalho dos; Martins, Karine Anusca
Introduction: Vitamin D plays a role in several metabolic pathways, including cell diferentiation and proliferation, hormonal control, modulation of inflammation and immune system regulation. Since vitamin D receptors are presented in different tissues and organs, it is related to many diseases, such as obesity, hipertension and dyslipidemia. Objective: To evaluate the serum levels and the effect of cholecalciferol supplementation on body composition and metabolic profile in of children. Methods: A randomized, placebo-controlled, triple-blind, crossover study was conducted with 62 children, 4 to 11 years old, from a public educational institution, that met the selection criteria. Sociodemographic, economic and sunscreen use data were collected from a specific questionnaire; the body area daily exposed to the sun was evaluated by a questionnaire with a representative figure of the body percentage; a specific questionnaire was used to evaluate physical activity and sedentary behavior; anthropometry (body mass and height) and body composition (waist circumference, body fat percentage, fat-free mass, triceps and subscapular skinfolds) were obtained using a stadiometer, electronic scale, anthropometric tape, tetrapolar bioimpedance and adipometer; blood pressure was measured using an automatic digital monitor; 25-hydroxyvitamin D [25(OH)D], fasting glucose and lipid profile were analysed from blood collection; and food intake data was evaluated through the 24-hour recall. In the intervention study, the two groups, supplemented and placebo, received 5 drops of cholecalciferol (1000 IU/day) and 5 drops of sunflower oil (placebo), respectively, for 12 weeks, separated by 10-week washout period. Results: Among children with sufficient serum vitamin D (≥ 75 nmol/L), who participated in the baseline study, no difference was found in sex, self-reported race, physical activity, age, anthropometry, body composition, biochemical parameters and blood pressure between children with 25(OH)D 75-99 and ≥ 100 nmol/L, in addition to the non-association of 25(OH)D with body composition and metabolic profile. In the crossover study, conducted with hypertriglyceridemic children, cholecalciferol supplementation reduced serum total cholesterol (TC) (p < 0.001), LDL-c (p < 0.001), non HDL-c (p < 0.001), TC/HDL-c (p = 0.001) and LDL-c/HDL-c (p < 0.001) ratio, when compared to placebo group. Conclusions: Serum vitamin D was not associated with body composition and metabolic profile among children with 25(OH) ≥ 75 nmol/L, and 1000 IU/day of cholecalciferol supplementation, for 90 days, in hypertriglyceridemic children without 25(OH)D serum deficiency, was able to improve lipid profile.
Desenvolvimento farmacotécnico e analítico de comprimidos revestidos de montelucaste: equivalência farmacêutica e bioequivalência
(Universidade Federal de Goiás, 2011-03-18) ALVES, Carina Pimentel Itapema; LIMA, Eliana Martins; http://lattes.cnpq.br/7248774319455970
Montelukast is a potent reversible selective inhibitor of cysteinilleukotrien- 1 receptor, avoiding that these mediators promote the asthmatic response. Its commercialization in Brazil, as a terminated product, is protected by patent up to 2010. Once the active ingredient Montelukast is recent in the pharmaceutical market and there is no methodology description in official compendiums capable to assure the quality of new formulations, the objective of this paper was the pharmaceutics of montelukast film coated tablets, the development and the validation of analytical and bioanalytical methodologies foreseeing the pharmaceutical equivalence and bioequivalence with the reference medication of the market. With this purpose, some physicalchemical parameters were characterized, assay and dissolution methodologies were developed and validated per high performance liquid chromatography with ultraviolet detection (HPLC-UV) for the quantification of montelukast present in 10.0mg film coated tablets. The quantification of montelukast sodium in human plasma was performed using Loratadine as internal standard and high performance liquid chromatography attached to mass detector (HPLC - MS / MS). The active ingredient was extracted from the human plasma using precipitation extraction. The results found for the parameters of specificity, linearity, accuracy, precision, quantification and detection limits and stability in the methodologies validation confirm they were adequate for the objective proposed. The analytical methodologies developed and validated were applied in the pharmaceutics of the tablets for the determination of the formulation similar to the market reference medication Singulair®. This formulation was submitted to stability assays to assure its quality and to allow the performance of pharmaceutical equivalence and bioequivalence with the purpose of registering as a generic medication.
A ultrassonografia no rastreamento da qualidade óssea na perspectiva da osteoporose
(Universidade Federal de Goiás, 2016-04-04) Andrade, Sara Rosa de Sousa; Amaral, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Sousa, Juarez Antônio de; Iannetta, Odilon; Ferreira, Ruy Gilberto; Brasileiro, Marislei de Sousa Espíndula
To determine the accuracy of the phalanx ultrasound and bone quality tracker element in view of osteoporosis, produce a review article covering the various diagnostic methods for osteoporosis; establish diagnostic tests ultrasonometry as bone quality, according to age, set a Bone Quality nomogram (UBPI) view ultrasound and build bone quality normal curve according to age setting the cut off of pathological risk. Methods: A descriptive, analytical study of diagnostic accuracy. Attended the screening 932 women, of these, 125 were selected for agreeing to participate and fit the inclusion and exclusion criteria. They were oriented to addressing the Women's Hospital and Maternity Hospital Iris to achieve the phalanx ultrasound scans and bone densitometry. Results: to evaluate the osteossonografia phalanx in relation to spinal bone densitometry test sensitivity was 80% in Group 1 and 100% for G2, G3 and G4. In relation to the femur test sensitivity was 90% and G1 100% G2, G3 and G4. When analyzing the 50th percentile, there was a significant inverse correlation showing that the higher the age, the greater the loss of bone quality. When the disease risk was calculated the results were, for the age group 30-39 years the average: 0.68 and SD: 0.23; 40-49 years, mean 0.64 and SD: 0.28; 50-59, mean and SD years: 0.54 and 0.37, respectively, and finally, age> 60 years, mean and SD: 0.32 and 0.30. Conclusion: a phalanx of ultrasonometry proved to be a method of good accuracy, as part crawler osteoporosis, regarding the evaluation of bone quality. The sensitivity of the phalanx ultrasound was calculated and comparative test densitometry, effective results were obtained, varying between 80 and 100%. When the nomogram was built, it can be seen the evidence that bone quality has a gradual loss with increasing age, but also the ability of this method to check that early. As for the ultimate goal of building a normal curve to calculate the pathological risk the results were, for the age group 30-39 years the average: 0.68 and SD: 0.23; 40-49 years, mean 0.64 and SD: 0.28; 50-59 years, mean and SD: 0.54 and 0.37, respectively, and finally, age> 60 years, mean and SD: 0.32 and 0.30.
BEVACIZUMABE INTRA-VÍTREO: ANÁLISE DA TOXICIDADE RETINIANA APÓS 3 MESES EM OLHOS DE COELHOS NÃO ALBINOS
(Universidade Federal de Goiás, 2009-06-19) ARRAES, João Carlos Diniz; ÁVILA, Marcos Pereira de; http://lattes.cnpq.br/3335187297522447
Antiangiogenesis therapy has become a first-line treatment for neovascular age-related macular degeneration (AMD). Bevacizumab has proven to be efficient and cost effective, however its use in AMD is still off-label. PURPOSES: Evaluating the histological toxicity of bevacizumab on the neurosensorial retina (NSR) and the retinal pigmented epithelium (RPE) in pigmented rabbit eyes; evaluating if a fast increase in vitreous volume after a 0.1 ml balanced saline solution (BSS) intravitreal injection (IVI) in a rabbit eye will lead to histological damages in the NSR and RPE; and evaluating postoperative clinical complications after an IVI in rabbits eyes. METHODS: Eighteen pigmented rabbits (36 eyes) were divided into 4 groups a Control Group (3 rabbits - 6 eyes), which did not receive any IVI; the rabbits were sacrificed at the beginning of the study. Thirty eyes of the fifteen remaining rabbits were distributed to three groups: a sham group (S), that received a 0.1 ml balanced saline solution (BSS) IVI (ten eyes); group 1, that received a 1.25 mg (0.1 ml) bevacizumab IVI (ten eyes); and group 2, that received a 2.5 mg (0.1 ml) bevacizumab IVI (ten eyes). Postoperative clinical evaluation included inspection of the anterior segment and indirect binocular ophthalmoscopy. The rabbits were sacrificed 90 days after the procedure and both eyes of all the rabbits were enucleated. Histological examination of the NSR and RPE were performed and their morphological features and layer thickness were analyzed. RESULTS: No significant postoperative clinical complications were observed either in the neurossensorial retina or in the RPE. Histological morphology and thickness of the NSR and RPE layers did not differ significantly between BBS-injected eyes and bevacizumab-injected eyes. CONCLUSIONS: A rapid increase in vitreous volume, after 0.1 ml BSS IVI did not lead to any histological damage in the NSR and RPE in rabbit eyes. After a 90-day follow-up period, a single Bevacizumab 1.25 and 2.5 mg intravitreal injection did not lead any toxic damage in the NSR and RPE. No important postoperative complications in pigmented rabbit eyes were observed and it appears to be a safe procedure for the treatment of retinal neovascular diseases
Comparação entre dois protocolos para estimulação ovariana com agonista/antagonista do hormônio liberador de gonadotrofinas (GnRH) em mulheres submetidas ao primeiro ciclo de reprodução assistida
(Universidade Federal de Goiás, 2013-07-01) Arruda, Jalsi Tacon; Approbato, Mário Silva; http://lattes.cnpq.br/3408700658976397; Approbato, Mário Silva; Barbosa, Maria ALves; Bérgamo, Nádia Aparecida; Siriano, Liliane da Rocha
Infertility affects more couples and assisted reproduction techniques offer a possibility of treatment and the chance of having a child. Thus, the first attempt to ovulation induction is critical to the success of the cycle or even for future attempts is successful. Objective: To compare the protocols using GnRH agonist or antagonist for ovarian stimulation in normo-responders undergoing the first cycle of IVF/ICSI. Methods: we conducted a literature review on the history of ovulation induction controlled by medications. From the data available in the database of electronic medical records SISFERT used in the Laboratory of Human Reproduction (LabRep-HC-FM-UFG) a comparative retrospective observational study was conducted with 50 patients divided into two groups according to protocol: GnRH-agonist (leuprolide acetate 1 mg/day short protocol) or GnRHantagonist (Cetrorelix 0.25 mg/day), which received 150 IU/day of rFSH (follitropin alpha) and 250 µg of rhCG (alpha-coriogonadotrofina) in both groups. Results: Statistically significant differences were observed in the days of stimulation with rFSH, total dose of gonadotropin, days of use of GnRH, GnRH dose and total number of follicles (≥ 16 mm) on the day of the group rhCG GnRH agonist. There was no significant difference in other parameters, however, the number of oocytes retrieved was slightly higher in the GnRH agonist, but fertilization rate was higher in the GnRH-antagonist. Pregnancy rates and clinical chemistry were similar in both groups. Conclusions: although no significant differences in the results analyzed, the use of flexible antagonist protocol facilitates the handling and enables the patient using much lower doses of gonadotropins itself as the antagonist, reducing the cost of treatment when compared to the protocol with GnRH agonist.
Efeitos de um programa individualizado e supervisionado de exercícios para os músculos do assoalho pélvico em multíparas de parto vaginal
(Universidade Federal de Goiás, 2012-04-16) ASSIS, Thaís Rocha; AMARAL, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579
This study consists of two scientific papers. The first aimed at investigating the effects of an individualized and supervised exercise program to strengthen pelvic floor muscles (PFM) in the postpartum period of multiparous women, and verify the correlation between two methods used to assess muscle strength. The second paper aimed at verifying the perception that puerperal women have regarding the alterations to their vaginal area and sex life after childbirth and after a PFM exercise program. To achieve these goals, an open clinical trial was performed on the first study, while the second conducted an exploratory and descriptive study. The final sample consisted of 23 puerperal women divided into two groups: intervention group (IG, n=11) and control group (CG, n=12). In IG, the puerperal women participated in an eight-week PFM exercise program, twice a week. In CG, the puerperal women did not receive any recommendations regarding exercises. PFM strength was assessed by digital vaginal palpation using the modified Oxford Scale and perineometer. The statistical analysis of the first article was performed using the following tests: Fisher s Exact Test, Chi-squared Test, Student s t-test, Kolmogorov Smirnov test for the two samples, and Pearson s Correlation Coefficient. Significance was defined as p < 0.05. On the second paper, categories were established and content analysis was performed. The participants mean age in IG was 24 ± 4.56 years, and 25.33 ± 4.03 years in CG (p=0.465). By completing the PFM exercise program, a significant difference was observed between the groups in the two muscle strength assessments (p0.001). The two methods used to assess muscular strength showed significant correlation in both assessments (1st assessment: r = 0.889 with p <0.001; 2nd assessment: r = 0.925 with p <0.001). In terms of the participants perception regarding any vaginal alteration in the late postpartum period, the most frequent reports in both groups were those related to the category perception of low vaginal tonus . Fourteen weeks into the postpartum period, at the end of the exercise program, the participants in IG presented more reports in the category perception of increased vaginal tonus and greater control over the PFM and those in the CG, in the category feels that the vagina is back in the same condition as before pregnancy . Finally, the exercise program resulted in a significant increase in PFM strength in puerperal women and showed positive effects on the perineal area and in the sex life of the participants. Good correlation was observed between digital vaginal palpation and perineometer, which indicates that vaginal palpation can be used in clinical practice, considering it is an inexpensive method that demonstrated significant correlation with an objective method, i.e. perineometer.
Alterações metabólicas, qualidade de vida e capacidade funcional de idosos atendidos na estratégia de saúde da família de um munícipio de Goiás
(Universidade Federal de Goiás, 2016-05-27) Avelar, Ivan Silveira de; Silva, Maria Sebastiana; http://lattes.cnpq.br/1329422634395496; Silva, Maria Sebastiana; Souza, Nilva Pessoa de; Campos, Mário Hebling; Nora, Fernanda Grazielle da Silva Azevedo; Gassi, Ewerton Rodrigo
Aging involves neural structural, functional and chemical changes that generate a number of diseases. Among the diseases that affect the elderly stand out metabolic and functional, such as metabolic syndrome and loss of muscle strength, which are closely related to the quality of life and are influenced by inadequate nutritional status and physical inactivity. Studies show that protein supplementation can increase muscle strength and improve body composition. The objective of the study was to evaluate the metabolic changes and the quality of life as well as the effects of a water aerobics program associated with supplementation of soy protein in muscle strength, hydration status and body composition of the elderly. The research began with the participation of 63 elderly aged ≥ 60 years. We determined the frequency of metabolic syndrome and assessed the quality of life of those with and without SM, using the SF-36. Still, the elderly were subjected to a water aerobics program associated with supplementation of soy protein for six months and evaluated for manual pressure force by force transducer manual, and state hydration and body composition by BIA. The normality of the data was assessed by the Shapiro-Wilk. The Mann-Whitney test was used to compare the variables of MS and the scores of quality of life between the groups with metabolic syndrome (CSM) and without metabolic syndrome (SSM). The scores of each SF-36 domain were divided into tertiles and associated with individuals with and without MS using the chi-square test of Pearson (2). In the study evaluating the effect of water aerobics program with or without supplementation used the Student t test for independent samples to compare the variables with normal distribution between the groups and the Mann-Whitney test to compare variables without normal distribution. In the above analysis we used the SPSS software and adopted the significance level of p <0.05. The vectors of BIVA were analyzed by Hotelling's T2 tests and univariate analysis (F test). The distances between the vectors in each group were correlated, was also calculated and, using Mahalanobis distance D (D). The vectors were analyzed using the software BIVA 2002. The effect of supplementation on strength and body composition was assessed by analysis of variance (ANOVA) for repeated measures with Bonferroni post hoc. The results indicated a prevalence of 79.03% of elderly patients with metabolic syndrome. There was no difference between the domains of quality of life among older people with and without MS. qualitative improvement was observed in the above hydration. The study indicated a high frequency of metabolic syndrome but did not affect the quality of life of the studied group. The manual force had a significant increase (p=0.001) in the group that underwent aquatic exercise performed and consumed the soy protein supplement. Fat-free mass was significant loss in the group that used the protein supplement. The practice of gymnastics, with or without supplementation increased the manual pressure force, but did not change the body composition of the elderly.
Impacto da educação continuada realizada pelo laboratório de monitoramento externo da qualidade na acuidade dos resultados dos exames citopatológicos do colo do útero
(Universidade Federal de Goiás, 2014-03-21) Ázara, Cinara Zago Silveira; Manrique, Edna Joana Cláudio; http://lattes.cnpq.br/7574704691846518; Amaral, Rita Goreti; http://lattes.cnpq.br/3665611660713029; Amaral, Rita Goreti; Conde, Délio Marques; Guimarães, Janaína Valadares; Barbosa, Maria Alves; Feres, Valéria Christina de Rezende
The effectiveness of cytopathology exams demands high quality training, continued education and highly skilled professionals to guarantee a reliable, accurate exam, aimed at reducing false results. Objective: To evaluate the effect of a continued education program conducted by the External Quality Control Monitoring Laboratory (LabMEQ), assessing the agreement of the results and internal quality control indicators. Methods: To analyze the agreement of the results, 19,826 exams conducted between 2007 and 2011 and selected through the cervical cancer data system (SISCOLO) were evaluated, 9,798 of these exams having been performed prior to the implementation of continued education and 10,028 after implementation. The statistical analysis was performed using the chi-square test, with p-values < 0.05 being considered statistically significant and the kappa coefficient was calculated. To analyze the internal quality control indicators, 185,194 exams performed between 2007 and 2012 were evaluated. Data for these exams were obtained from the SISCOLO, with 98,133 having been performed prior to the implementation of continued education and 87,061 after implementation. The following indicators were calculated: positivity index (PI), percentage of exams compatible with a high-grade squamous intraepithelial lesion (HSIL/satisfactory), percentage of atypical squamous cells among all abnormal smears (ASC/abnormal) and the ratio between atypical squamous cells and intraepithelial lesions (ASC/SIL). Continued education was provided every two months to the professionals from the participating laboratories in the form of theoretical and practical classes to discuss discordant cases and the standardization of cytomorphological criteria. Results: After the implementation of continued education, a reduction was found in the percentage of false-negative results that lead to delays in clinical management in eight laboratories and there was an improvement in the rate of false-positive results in five. There was no improvement observed in the unsatisfactory results. The agreement of the cytopathology exam results, according to the clinical management, remained excellent in three laboratories (kappa > 0.80), increased from good (kappa > 0.60 and < 0.80) to excellent (kappa > 0.80) in seven and from excellent to good in two laboratories. The agreement in the identification of the metaplastic epithelium, which was poor (kappa = 0.25), was classified as excellent after implementation of the continued education program (kappa = 0.95). The agreement of the results, according to the diagnosis, improved significantly following continued education in unsatisfactory cases (p<0.001), in cases of atypical squamous cells of undetermined significance (ASC-US) and atypical squamous cells cannot exclude HSIL (p<0.001), low-grade squamous intraepithelial lesions (p<0.001) and atypical glandular cells (p<0.001). Following implementation of the continued education program, the positivity index (PI) remained within recommended limits in four laboratories. In another four laboratories, the PI progressed from below the limits to within the recommended standards. In one laboratory, the PI remained low, in two laboratories, it remained very low, and in one, it increased from very low to low. The HSIL/satisfactory remained within the recommended limits in five laboratories, while in three laboratories it progressed from below the recommended levels to >0.4% of the total number of satisfactory exams, and in four laboratories it remained below the standard limit. Both the percentage of ASC/abnormal and the ratio ASC/SIL remained within recommended levels in all the laboratories investigated. Conclusion: The results of this study show that the continued education program conducted by LabMEQ with the laboratories was effective as a measure aimed at standardizing cytomorphological criteria, since there was an improvement in the reproducibility of the results and in the indicators of internal quality control, leading to a reduction in the number of false results.
A contratualização no âmbito da gestão do Hospital das Clínicas da Universidade Federal de Goiás: análise do período de 2001 a 2013
(Universidade Federal de Goiás, 2017-03-30) Azevedo, Jane Mary Rosa; Barbosa, Maria Alves; http://lattes.cnpq.br/5025797873585225; Oliveira, Ênio Chaves de; http://lattes.cnpq.br/7046861881778720; Oliveira, Ênio Chaves de; Reis, Ademar Arthur Chioro do; Coelho, Maria Alice; Teixeira, Ricardo Antônio Gonçalves; Oliveira, Ellen Synthia Fernandes de
This thesis reports a descriptive exploratory case study with qualitative and quantitative approach carried out at the Hospital das Clínicas of the Federal University of Goiás. Its objective is to analyze the possible impacts resulting from the contractualisation process implemented in 2004 with the Municipal Secretary of Health of Goiânia. It analyzed the period from 2001 to 2013, focusing on the production of health care, indicators of hospital performance, financial aspects and investments. A document analysis was made available by the institution and a semi-structured interview with seventeen managers who worked in the management before and after the contracting process of the institution, the Municipal Health Department of Goiânia and the Ministries of Education and Health. The quantitative data and the content analysis for the qualitative ones, using WebQDA software. The results showed that there was a financial impact with contracting, with a reduction in hospital care production, unmet physical goals, low institutional performance with reduction of occupancy rates, idleness, turnover, and reduction in the number of beds. In the manager’s perception, contracting is a definitive policy for hospitals that attend the Brazilian Unified Health System and its effectiveness has brought several benefits, although there are still aspects to be reviewed, such as quantity and quality of human, financial and other resources. It is concluded that this process contributes to decisions and executions actions related to this management model, committed to the quality of health services provided to the population. Negotiations and more feasible pacts are suggested, with compliance with the Ordinance and constant participation of federal, municipal and institutional managers, favoring both hospital performance and improved quality.
Prevalência de problemas de saúde mental em populações de crianças e adolescentes indígenas Karajá da Amazônia brasileira
(Universidade Federal de Goiás, 2012-03-14) AZEVÊDO, Paulo Verlaine Borges e; CAIXETA, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509
Objective: To determine the prevalence of mental disorders in children and adolescents from an indigenous population living in isolated tribes in the Brazilian Amazon. Methods: This is an analytical prevalence study in a sample of 192 indigenous children and adolescents from Karajá ethnicity, aged between 7 and 14 years old. The prevalence were determined using the syndrome scales of mental health problems according to the ASEBA questionnaires. The Child Behavior Checklist 6-18 (CBCL) and the Teacher Report Form 6-18 (TRF) were used for the screening of these problems. The difference among the prevalence found in the two questionnaires as well as the risk association between gender and schooling and mental health problems were evaluated. Results: A total prevalence of problems of 34.38% with the CBCL and of 23.44% with the TRF was found (p < 0.00). There was an association between the occurrence of these problems in the subjects attending the second phase of fundamental school (6th to 9th year of formal education). Conclusion: The prevalence of mental health problems found was high when compared to studies with other cultures around the world. It was observed that even in human populations who preserve the primordial cultural aspects of their ancestors who lived 10.000 years ago, psychiatric problems exist and have clinical presentations that are similar to those found in modern civilized societies, in which the cultural context may influence the manifestations of such problems.
Avaliação do tempo de trânsito orocecal e do teste de tolerância à glicose em pacientes chagasicos e não chagasicos com ou sem constipação intestinal
(Universidade Federal de Goiás, 2014-06-10) Bafutto, Mauro; Oliveira, Ênio Chaves de; Oliveira, Ênio Chaves de; Rezende Filho, Joffre; Alves Neto, Onofre; Silva, Nilsio Antônio da; Ramos, Gilson Cassen
Background : Most patients with chagasic megacolon presents constipation. However in about one third of patients, despite the megacolon, bowel habits are normal.On the other hand, Chagasic patients may show constipation without evidence of colonic involvement.Thus, the determining factors of constipation in Chagas disease, are not completely understood. The question then arises: if it's not the megacolon solely responsible for constipation, what other factors are involved? In an attempt to answer this question, we evaluated the possibility of involvement not only of the colon, but also of the small intestine, very important organ in the absorption of nutrients and the formation of fecal bolus. This study evaluated whether there is change on orocecal transit and glucose absorption in the small intestine of Chagasic patients and non Chagasic with or without constipation by orocecal transit time measurement and the oral glucose tolerance test. Methods :Six groups of patients were studied: 1) – control group-Without constipation without megacolon and negative for Chagas disease serology; 2)-With constipation without megacolon and negative serology for Chagas disease; 3)-With constipation without megacolon and positive serology for Chagas disease; 4)-Without constipation without megacolon and positive serology for Chagas disease, 5)-With constipation with megacolon and positive serology for Chagas disease. 6)-Without constipationwith megacolon and positive serology for Chagas disease. For measurement of the orocecal transit time was used the H2 expired test. Results : It was observed a great extension of this time in the Group of patients with chagasic megacolon and constipation, which was statistically significant (p=0,001) when compared to all the other groups studied. It was observed that this time is greater in constipated than not constipated (p=0,005). The oral glucose tolerance test used in the evaluation of glycemic curve, showed that blood glucose levels were lower in Chagas disease patients, with statistically significant difference in relation to patients with Chagasic constipation and/or megacolon at 30 (p=0,003),60(p=0,005) e 90 minutes (p=0,001). It was interesting to note that patients with constipation and megacolon, were the only ones among all groups, which showed statistically significant difference at the same time both for the glucose tolerance test as to orocecal transit time. In conclusion, Chagasic patients with constipation and megacolon the orocecal transit time is delayed and during glucose tolerance test present highest rates of blood glucose.These data can correspond to a dysfunction of peristalsis and glucose absorption in the small intestine in patients with Chaga´s disease presenting with megacolon and constipation.
Intervenção educativa pró-adesão farmacológica em pacientes com leucemia mielóide crônica tratados com mesilato de imatinibe em Goiânia Goiás
(Universidade Federal de Goiás, 2015-04-10) Barbosa, Adriana do Prado; Cunha, Luiz Carlos da; http://lattes.cnpq.br/6349547031976679; Cunha, Luiz Carlos da; Arantes, Adriano de Moraes; Silva, Nílzio Antônio da; Parente, Leila Leal; Ghedini, Paulo César
The treatment of chronic myeloid leukemia (CML) has changed dramatically with the advent of imatinib mesylate (IM). Besides the convenience of oral use, other benefits were achieved with the new drug, with faster therapeutic responses and increased survival, giving the CML similar characteristics as chronic diseases. In this scenario, there was another challenge, drug compliance, since a significant proportion of patients fail to ingest all the prescribed doses of imatinib. The concern was to optimize the adherence of CML patients, the hematology ambulatory at the Clinical Hospital of the Federal University of Goias (HC-UFG), led the authoress to create a film cartoon, as a pro-adhesion educational intervention model. To investigate the effectiveness of this new educational material, we used in 65 patients three adherence measures, two indirect (Morisky Test and Molecular Response [MR]) and direct (plasma dosage of IM), before and after the screening of film. In univariate analysis, from the Morisky Test, the film was striking, with increased adherent patients, which increased from 15 (23.1%) to 43 (66.1%). The results of MR showed an improvement trend after the movie, because the positive molecular response (major MR or complete MR) increased from 81.5% to 86.1%. Regarding the serum levels of IM, with daily doses of 400-800 mg IM, the premovie samples showed higher average than the post-movie (2473.16 ± 1049.55 ng/ml versus 1414.72 ± 715 73 ng/ml), with a variation coefficients interpatients of 43.4% and 50.6%, respectively. This high dispersion index found has been reported by other authors. By multivariate analysis, patients were divided into three groups. The first brought together compliant patients before and after the film with a good therapeutic response (major MR) after the intervention. It was: patients over 53 years old, females, with associated diseases before and after the treatment of CML that use more than two drugs in addition to imatinib. The second group was marked by the change of not adherence pre to adherence post-film. Its features were younger than or equal to 53, the absence of other disease before the CML, the use of less than two drugs and complete molecular response after the film. In the third group, we observed patients without molecular response before and after the educational intervention and no medication adherence after the film. They had in common their age (less than or equal to 53 years), and drug discontinuation due to adverse reactions. The last represents the set of patients resistant to the educational film, drawing attention to the fact that only one pro-adhesion method may be insufficient for all individuals. It is concluded that medication adherence was higher among patients older than 53 years, the educational film is an effective proadhesion assistance and continuing education, if combined with another method, it could help maintain or enhance the benefits achieved in this work.
Composição corporal e antropometria de idosos:concordância entre métodos, desenvolvimento e validação de equações preditivas e pontos de corte
(Universidade Federal de Goiás, 2011-05-09) BARBOSA, Larissa Silva; SILVEIRA, Erika Aparecida da; http://lattes.cnpq.br/3801865783333828
The aim of this study was to assess body composition and anthropometry of the elderly with regard to agreement between methods, development and validation of predictive equations and cutoffs. We evaluated 132 elderly patients (52 men and 80 women) aged between 60 and 91 years, users of primary health care, not institutionalized and drawn at random in proportion to the nine health districts of Goiânia, GO. For collection of anthropometric measurements, bioelectrical impedance (BIA) and dual energy x-ray absorptiometry (DEXA), standardized procedures were used by trained examiners and equipment was calibrated regularly. Analyses were performed using STATA/SE. Descriptive analysis, tests for comparison of means, equation validation according to criteria suggested by Lohman, Bland-Altman and Lin graphic analysis and ROC (receiver operator characteristic curve) analysis were carried out. The project was approved by the Ethics Committee of the Federal University of Goias. The Durnin and Womersley equation showed the highest concordance correlation coefficient (CCC = 0.846) and the lowest mean differences (MD = - 2.335) for males. The equations of Lean et al. (for men) and Deurenberg et al. (for women) showed the highest correlation with and lowest mean differences from DEXA. Equations were proposed to estimate body fat percentage (BF%): (males: BF% = - 16.868 + 0.571TSF + 0.409WC and females: BF% = 8.634 + 0.601BMI + 0.321SISF + 0.234SSSF + 0.398TSF 0.467BSF). In both sexes, the equations are similar to DEXA in estimating BF% with high precision and accuracy. In males, the proposed body mass index (BMI) cutoff point was ≥ 25 kg/m2; the waist circumference (WC) cutoff point was ≥ 98.9 cm. In women, the BMI and WC values with the most sensitivity, specificity and accuracy were ≥ 26.6 kg/m2 and ≥ 90.5 cm. Since the currently available equations for predicting body composition of elderly have certain limitations, these newly developed and validated equations for the two sexes can be recommended for wide use. Accurate BMI and WC cutoff points for predicting BF% in older adults were also identified.
Autopercepção da saúde e da qualidade de vida, desempenho funcional e prática de atividade física entre idosos residentes em município rural no interior do Brasil
(Universidade Federal de Goiás, 2021-07-16) Barbosa, Renata da Costa; Sousa, Ana Luiza Lima; http://lattes.cnpq.br/6578713509935374; Sousa, Ana Luiza Lima; Souza, Weimar Kunz Sebba Barroso de; Batista, Sandro Rogério Rodrigues; Zanini, Claudia Regina de Oliveira; Leite, Márcia Andréa Gonçalves
Aging can lead to greater dependence on the individual, compromising functional performance, self-perception of health and quality of life. A physically active lifestyle can provide the maintenance of functionality and improve the quality of life and health of the elderly. Behavior and lifestyle habits may be influenced by the location where the elderly person lives. Understanding how elderly people living in rural municipalities perceive their health and quality of life can provide subsidies to better help these populations. Objective: To analyze the associations between self-perceived health and quality of life with functional performance and the practice of physical activity among elderly people living in rural municipality in Brazil. Method: Analytical cross-sectional population-based study. Individuals aged 60 years or more, noninstitutionalized, living in a rural municipality in the interior of Goiás were included. Sociodemographic, anthropometric and lifestyle variables were evaluated. In addition, functional performance was assessed using the Timed Up and Go (TUG) test and physical activity practice using the International Physical Activity Questionnaire (IPAQ). As outcome variables, self-perceived health and quality of life were assessed using the Bref and Old World Health Organization Quality of Life Instruments questionnaires (WHOQOL BREF and WHOQOL OLD). Data were obtained during a home visit, by an interview. To assess the association of the variables of interest, Pearson's chi-square test, Fisher's exact test and the Wilcoxon sign were used. Results: The study included 142 elderly people with a mean age of 72.4 (±8.0) years. More than half were classified as sufficiently active (66.9%), among these, 55.8% performed leisure activities, the vast majority were independent in activities of daily living (87.3%), with regular/good quality of life (average overall score: 3.6±0.3) and, respectively, 57.7% and 64.1% had self-perceived health and quality of life. Elderly people with poor or very poor self-perceived health had regular self-perceived quality of life (63.6%), individuals aged 80 years and over had lower self-perception of quality of life compared to others. There was an association of self-rated health with the practice of physical activity and functional performance. However, no associations were found with the type of physical activity. It was found that 50.0% of the elderly who were insufficiently xvii Abstract 18 active and independent perceived their health positively. Of the insufficiently active and dependent elderly, 35.7% had poor/very bad and good/very good self-perceived health. Conclusions: Elderly people living in a rural municipality showed good or very good perception of health and quality of life, independent in their activities of daily living and sufficiently active. Self-perceived health was associated with quality of life, functional performance and physical activity practice, not being associated with the other study variables.

Navegar

Navegando Doutorado em Ciências da Saúde (FM) por Por Tipo de Defesa "Tese"

Resultados por página

Opções de Ordenação